Interaction of Some Aminophosphonic Acids with Urea in Aqueous Solutions at 298.15 K

Abstract

The enthalpies of solution of aminomethylphosphonic acid (GlyP), 1-aminoethylphosphonic acid (AlaP), and 1-aminopropylphosphonic acid (HalaP) have been measured in water and aqueous urea solutions at 298.15 K. From the obtained experimental results, the standard enthalpies of solution of aminophosphonic acids (AP) in water–urea solutions have been determined. These data were used to calculate the heterogeneous enthalpic pair interaction coefficients based on McMillan–Mayer's formalism. These values were interpreted in the terms of the hydrophobic effect of the side chains of aminophosphonic acids on their interactions with a molecule of urea in water.

Calorimetric Studies of the Interactions between Several Aminophosphonic Acids and Urea in Aqueous Solutions at 298.15 K

“…Our laboratory has long carried out studies on the interactions of l -α-amino acids with the components of body fluids, among other things, urea. − As aminophosphonic acids are disseminated in the environment, it is of interest to assess their interactions with urea occurring in vertebrate organisms as a component of the urea cycle. In the industry, urea is used as an additive to cosmetics and occurs in animal foodstuff, it is a component of many chemical fertilizers.…”

Resolution of Enantiomers of Novel C2‐Symmetric Aminobisphosphinic Acids via Diastereomeric Salt Formation With Quinine

“…α‐Aminoalkylphosphinic acids are considered structural analogs of α‐amino acids and possess potential biological activities applicable to antibiotics, enzyme inhibitors, pharmacological agents, antiviral agents, and herbicides (Figure ) . Since the structure of the phosphinic functional group mimics the unstable tetrahedral intermediates formed in enzyme‐mediated peptide bond cleavage, some pseudo‐peptides derived from α‐aminophosphinic acids are known to act as inhibitors of proteolytic enzymes such as metallo‐ and serine‐proteases …”