Current Opinion in Lipidology volume 25, issue 5, P333-338 2014 DOI: 10.1097/mol.0000000000000106 View full text
Dmitri Sviridov, Michael Bukrinsky

Abstract: Purpose of the review Pathogens of different taxa, from prions to protozoa, target cellular cholesterol metabolism to advance own development and to impair host immune responses, but also causing metabolic complications, e.g. atherosclerosis. This review describes recent findings of how pathogens do it. Recent findings A common theme in interaction between pathogens and host cholesterol metabolism is pathogens targeting lipid rafts of the host plasma membrane. Many intracellular pathogens use rafts as an e…

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