Interaction of Mitomycin C with DNA Immobilized onto Single‐walled Carbon Nanotube/Polymer Modified Pencil Graphite Electrode

Abstract

The electrochemical investigation of the interaction between the anticancer drug mitomycin C (MC) and DNA was described using a single-walled carbon nanotube (SWCNT)/poly(vinylferrocenium) (PVF + ) modified pencil graphite electrode (PGE). The electrochemical oxidation signals of guanine were monitored before and after the interaction between MC and DNA by using differential pulse voltammetry. The effects of DNA and MC concentration and MC interaction time were examined based on the electrode response. Cyclic voltammetry and electrochemical impedance spectroscopy were used for the characterization of SWCNT/PVF + modified and PVF + modified PGEs. The detection limit corresponded to 625 ng/mL for MC using calf thymus double-stranded DNA immobilized SWCNT/PVF + modified PGE.

Preparation of gold nanoparticles/single-walled carbon nanotubes/polyaniline composite-coated electrode developed for DNA detection

“…6). The detection limit that was found in the study was comparable with the other ones reported previously [29,30,38] .…”

“…The applications of electrochemical nanobiosensors are in increasing demand since they are rapid, sensitive, selective, easily prepared and low-cost devices. Much effort has been put on DNA detection for improving sensitivity, stability and reproducibility [24][25][26][27][28][29][30]. Electrochemical detection combined with nanomaterial technology achieves many of the goals mentioned above.…”

Aryl Biphenyl‐3‐ylmethylpiperazines as 5‐HT7 Receptor Antagonists

“…This decrease may be attributed that the repulsive electrostatic interactions between the OH − groups of CHIT biopolymer and anionic redox probe 33. The I c and Q c of Fe(CN) 6 3−/4− increased as 1.6 % and 3.2 % respectively after modification of PGE with 750 µg/mL CNT‐750 µg/mL CHIT mixture (Figure S1‐c Supporting Information) indicating CNT improved the electroactive surface area (Table S3 Supporting Information) and conductibility of electrode 16,11,24. After the immobilization of the 20 µg/mL fsDNA at the surface of CNT‐CHIT/PGE, I c and Q c values decreased as 69.1 % and 38.7 % respectively.…”

Iron(iii) and nickel(ii) complexes as potential anticancer agents: synthesis, physicochemical and structural properties, cytotoxic activity and DNA interactions

“…32,39,63 Firstly, the oxidation signals of the compounds were measured by using DPV technique. 32,39,63 Firstly, the oxidation signals of the compounds were measured by using DPV technique.…”