Interaction of hypercaloric diet and physical exercise on lipid profile, oxidative stress and antioxidant defenses

Burneiko, Regina C.; Diniz, Yeda S.; Galhardi, Cristiano Machado; Rodrigues, Hosana Gomes; Ebaid, Geovana M.X.; Faine, Luciane Aparecida; Padovani, Carlos Roberto; Cicogna, Antônio Carlos; Novelli, Ethel L. B.

doi:10.1016/j.fct.2006.01.004

Cited by 84 publications

(88 citation statements)

References 36 publications

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“…The present findings demonstrated that HF intake led to visceral adiposity with dyslipidemia in sedentary mice, in agreement with the literature (13,14). Thus, treadmill exercise was able to reduce visceral adiposity, serum triglycerides, and serum cholesterol and to improve HDLcholesterol concentrations.…”

Section: Discussionsupporting

confidence: 81%

“…Exercise training can prevent the accumulation of fat in the liver of rats receiving a high-fat diet (12). However, recent studies using a similar high-fat diet-induced obesity model in rats have shown that exercise had no effect on liver lipid accumulation (13,14). The reasons for this discrepancy are not clear, although differences in diet-induced fatty liver, in the exercise training program and techniques used for assessing liver lipid infiltration should all be considered.…”

Section: Introductionmentioning

confidence: 82%

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Beneficial effects of exercise training (treadmill) on insulin resistance and nonalcoholic fatty liver disease in high-fat fed C57BL/6 mice

Marques

Motta

TORRES

et al. 2010

Braz J Med Biol Res

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C57BL/6 mice develop signs and symptoms comparable, in part, to the human metabolic syndrome. The objective of the present study was to evaluate the effects of exercise training on carbohydrate metabolism, lipid profile, visceral adiposity, pancreatic islet alterations, and nonalcoholic fatty liver disease in C57BL/6 mice. Animals were fed one of two diets during an 8-week period: standard (SC, N = 12) or very high-fat (HF, N = 24) chow. An exercise training protocol (treadmill) was then established and mice were divided into SC and HF sedentary (SC-Sed, HF-Sed), exercised groups (SC-Ex, HF-Ex), or switched from HF to SC (HF/SC-Sed and HF/SC-Ex). HF/HF-Sed mice had the greatest body mass (65% more than SC/SC-Sed; P < 0.0001), and exercise reduced it by 23% (P < 0.0001). Hepatic enzymes ALP (+80%), ALT (+100%) and AST (+70%) were higher in HF/HF mice than in matched SC/SC. Plasma insulin was higher in both the HF/HF-Sed and HF/SC-Sed groups than in the matched exercised groups (+85%; P < 0.001). Pancreatic islets, adipocytes and liver structure were greatly affected by HF, ultimately resulting in islet β-cell hypertrophy and severe liver steatosis. The HF group had larger islets than the SC/SC group (+220%; P < 0.0001), and exercise significantly reduced liver steatosis and islet size in HF. Exercise attenuated all the changes due to HF, and the effects were more pronounced in exercised mice switched from an HF to an SC diet. Exercise improved the lipid profile by reducing body weight gain, visceral adiposity, insulin resistance, islet alterations, and fatty liver, contributing to obesity and steatohepatitis control.

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Section: Discussionsupporting

confidence: 81%

Section: Introductionmentioning

confidence: 82%

Beneficial effects of exercise training (treadmill) on insulin resistance and nonalcoholic fatty liver disease in high-fat fed C57BL/6 mice

Marques

Motta

TORRES

et al. 2010

Braz J Med Biol Res

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“…In our study, while exhaustive exercise significantly increased LDH activities in both groups, LDH activity was found higher in control group than the training group both at rest and after exhaustive exercise. Similarly, Burneiko et al (2006) stated that aerobic exercises continuing for 8 weeks decreased LDH activities. In contrast to these findings, it was reported that sportsmen had higher LDH values than sedentary individuals in the studies performed (Brites et al, 2006;Evelson et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

Effects of endurance training on exhaustive exercise-induced oxidative stress markers

Revan¹,

Erol²

2011

Afr. J. Pharm. Pharmacol.

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This study was aimed to investigate the effects of endurance training on lipid peroxidation and antioxidant enzyme levels in young adults. Twenty four male students participated in this study. Subjects were divided into two groups as training group (n=12) and control group (n=12). Subjects in the training groups performed running exercise 25 to 60 min/day, three days/week for eight weeks at an intensity of 50 to 70% of target heart rate. Blood samples collected at rest and after exhaustive exercise before and after 8 weeks, were analyzed for the determination of plasma lipid hydroperoxide (LOOH) level, and activities of glutathione peroxidase (GPx), catalase (CAT) and lactate dehydrogenase (LDH). LOOH level in the training group significantly decreased after the post-training period (p<0.05), but did not alter in the control group (p>0.05). LDH activities significantly increased both control and training groups after the exhaustive exercise (p<0.05). LDH activity was found significantly higher in control group than training group both at rest and after exhaustive exercise (p<0.05). GPx was not significantly altered by training and exhaustive exercise in both groups (p>0.05). In the training group, exhaustive exercise significantly increased CAT level after training period (p<0.05). Consequently, it can be said that endurance training is effective in prevention of lipid peroxidation caused by exhaustive exercise.

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“…Burneiko et al 37 destacam que a ingestão de dietas hiperenergéticas se associa com o desenvolvimento de câncer, doenças degenerativas relacionadas ao envelhecimento, dislipidemia, aterosclerose e doenças cardiovasculares. Os autores ressaltam que o estresse oxidativo vem sendo considerado importante elo em tais associações e que os efeitos benéficos da restrição energética podem estar associados à redução do peso corporal.…”

Section: F a T O R E S E X ó G E N O S M O D U L A D O R E S D O E S unclassified

Estresse oxidativo: conceito, implicações e fatores modulatórios

et al. 2010

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O estresse oxidativo decorre de um desequilíbrio entre a geração de compostos oxidantes e a atuação dos sistemas de defesa antioxidante. A geração de radicais livres e/ou espécies reativas não radicais é resultante do metabolismo de oxigênio. A mitocôndria, por meio da cadeia transportadora de elétrons, é a principal fonte geradora. O sistema de defesa antioxidante tem a função de inibir e/ou reduzir os danos causados pela ação deletéria dos radicais livres e/ou espécies reativas não radicais. Esse sistema, usualmente, é dividido em enzimático (superóxido dismutase, catalase e glutationa peroxidase) e não-enzimático. No último caso, é constituído por grande variedade de substâncias antioxidantes, que podem ter origem endógena ou dietética. Objetivou-se revisar os principais mecanismos de geração de radicais livres, bem como a ação dos agentes mais relevantes do sistema de defesa antioxidante, ressaltando suas implicações sobre os marcadores do estresse oxidativo. Também serão abordados os principais fatores exógenos moduladores do estresse oxidativo. Termos de indexação:Antioxidantes. Espécies reativas de nitrogênio. Espécies reativas de oxigênio. Estresse oxidativo. Radicais livres.

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Interaction of hypercaloric diet and physical exercise on lipid profile, oxidative stress and antioxidant defenses

Cited by 84 publications

References 36 publications

Beneficial effects of exercise training (treadmill) on insulin resistance and nonalcoholic fatty liver disease in high-fat fed C57BL/6 mice

Beneficial effects of exercise training (treadmill) on insulin resistance and nonalcoholic fatty liver disease in high-fat fed C57BL/6 mice

Effects of endurance training on exhaustive exercise-induced oxidative stress markers

Estresse oxidativo: conceito, implicações e fatores modulatórios

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