1995
DOI: 10.1021/bi00008a013 View full text |Buy / Rent full text
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Abstract: The association of plasma histidine-proline-rich glycoprotein (HPRG) with plasminogen (PLG) was examined using a sucrose density gradient assay in order to evaluate the effects of several relevant conditions on complex formation. Addition of PLG shifts the S-value of 125I-labeled HPRG from 4.8S to 6.8S, providing the first direct evidence that HPRG associates with the zymogen form of plasmin in solution. Complex formation is not sensitive to pH in the range of pH 6.5-8.5, but is abolished at high ionic strengt… Show more

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“…Previous studies based on chemical modification of lysines suggest that HRG binds to plasminogen via HRG lysine residues (46). The biosensor studies described herein support the notion that the plasminogen-HRG interaction is dependent on the well described lysine binding sites (LBS) (8) of plasminogen, as free L-lysine reversed the interaction.…”
Section: Discussionsupporting
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“…Previous studies based on chemical modification of lysines suggest that HRG binds to plasminogen via HRG lysine residues (46). The biosensor studies described herein support the notion that the plasminogen-HRG interaction is dependent on the well described lysine binding sites (LBS) (8) of plasminogen, as free L-lysine reversed the interaction.…”
Section: Discussionsupporting
“…2 supporting this view (46). It has been suggested that the carboxyl-terminal lysine residue on HRG is likely to be a candidate as one of the key plasminogen-binding residues (46).…”
Section: Analysis Of the Regions Of Hrg And Plasminogen Involved In Tmentioning
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“…Although the exact physiological function of HRG is unknown, a number of ligands for the molecule have been identified; these include heme (2), divalent metal ions (2), heparin (3,4), heparan sulfate (5), plasminogen (6,7), fibrinogen (8), and thrombospondin (9). HRG has been proposed to have a modular structure allowing it to bind several ligands independently (10), and evidence suggests that the interaction of HRG with glycosaminoglycans is regulated by metal ions and pH (11).…”
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