Journal of Cell Biology volume 217, issue 8, P2867-2876 2018 DOI: 10.1083/jcb.201801039 View full text
Teruki Funabashi, Yohei Katoh, Misato Okazaki, Maho Sugawa, Kazuhisa Nakayama

Abstract: Intraflagellar transport (IFT) is crucial for the assembly and maintenance of cilia and is mediated by IFT particles containing IFT-A and IFT-B complexes. IFT-B powered by heterotrimeric kinesin-II and IFT-A powered by the dynein-2 complex are responsible for anterograde and retrograde protein trafficking, respectively. However, little is known about the molecular basis of the trafficking of these IFT particles regulated by kinesin and dynein motors. Using the visible immunoprecipitation assay, we identified i…

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