Interaction of heat shock protein 70 (HSP70) polymorphisms and occupational hazards increases the risk of hypertension in coke oven workers

Zheng, Junhua; Lyu, Yi; Li, Ruifang; Tian, Fengjie; Mu, Jianbing

doi:10.1136/oemed-2018-105160

Cited by 6 publications

(7 citation statements)

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“…Recent studies have demonstrated that the expression of HSP70 increased in cerebral, myocardial and renal ischemia [29][30][31]. Furthermore, HSP70 was related to the pathogenesis of hypertension and associated diseases [17,19] and there were high levels of HSP70 in serum, plasma and placental tissue of PE patients [20].…”

Section: Rs2227956mentioning

confidence: 99%

“…As a stress protein, HSP70 plays a pivotal role in protecting cells against apoptosis, oxidative damage and genetic damage [17]. Placental ischemia, oxidative stress and maternal systemic inflammatory response, which play important roles in the pathogenesis of PE, have been shown to induce the expression of HSP70 [18].…”

Section: Introductionmentioning

confidence: 99%

“…Placental ischemia, oxidative stress and maternal systemic inflammatory response, which play important roles in the pathogenesis of PE, have been shown to induce the expression of HSP70 [18]. Moreover, studies indicated that HSP70 is involved in the pathogenesis of hypertension and associated diseases such as coronary heart disease, atherosclerosis, ischaemic stroke, Parkinson's disease, high-altitude illness and the forth, and there were high levels of HSP70 in serum, plasma and placental tissue of PE patients [17,19,20]. As several polymorphisms in HSP70 can influence protein expression or functions in some degree, thus may affect ability in stress tolerance and susceptibility to certain diseases [17].…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, studies indicated that HSP70 is involved in the pathogenesis of hypertension and associated diseases such as coronary heart disease, atherosclerosis, ischaemic stroke, Parkinson's disease, high-altitude illness and the forth, and there were high levels of HSP70 in serum, plasma and placental tissue of PE patients [17,19,20]. As several polymorphisms in HSP70 can influence protein expression or functions in some degree, thus may affect ability in stress tolerance and susceptibility to certain diseases [17]. And the gene variants involved in inflammation, oxidative stress, and thrombophilia were related to in the development in PE [21].…”

Section: Introductionmentioning

confidence: 99%

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HSPA1L rs1061581 polymorphism is associated with the risk of preeclampsia in Han Chinese women

et al. 2020

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Preeclampsia (PE) is an excessive systemic inflammation response with dysfunction of endothelial. As a stress protein, heat shock protein 70 (HSP70) plays a pivotal role in protecting cells against apoptosis, oxidative damage and genetic damage. In humans, three genes encode members of the HSP70 class: HSPA1A, HSPA1B and HSPA1L. Our study was to investigate the association between genetic variations of HSPA1L and the susceptibility for PE in Chinese Han population. The polymorphisms of rs2227956, rs1043618 and rs1061581 in HSPA1L were genotyped by TaqMan allelic discrimination real time polymerase chain reaction (PCR) in 929 PE patients and 1024 healthy pregnant women. Statistic difference of the genotypic and allelic frequencies were found in HSPA1L rs1061581 between PE patients and controls (χ2 = 29.863, P < 0.001 by genotype; χ2 = 27.298, P < 0.001, OR = 1.874, 95%CI 1.476–2.379 by allele) and HSPA1L rs1061581 A alleles occurred more frequently in PE patients compared with healthy controls (PE vs. controls 10.28% vs. 5.76%). Furthermore, we divided the PE cases into early-onset/late-onset PE and mild/severe PE subgroups and found statistical differences in genotypic and allelic frequencies of the HSPA1L rs1061581 between early-onset PE, late-onset PE, mild PE, severe PE and controls, respectively. Moreover, HSPA1L rs1061581 A alleles were more frequent in early-onset PE, late-onset PE, mild PE and severe PE than controls respectively. Therefore, we concluded that HSPA1L rs1061581 polymorphism is associated with the risk of PE in Han Chinese women and A alleles may play a role in the susceptibility for PE.

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Section: Rs2227956mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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HSPA1L rs1061581 polymorphism is associated with the risk of preeclampsia in Han Chinese women

et al. 2020

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“…In addition to lung injury, coke oven emissions also have adverse effects on the cardiovascular system. Therefore, more effective measures are needed to protect the health of coke oven workers [19,20]. High levels of 4-OHPh combined with longer working years or being overweight had a joint effect on the risk of diabetes.…”

Section: Organ Dysfunctions and Diseases Of Coke Oven Workersmentioning

confidence: 99%

Environmental Monitoring of PAHs Exposure, Biomarkers and Vital Status in Coke Oven Workers

Vimercati

Bisceglia

Cavone

et al. 2020

IJERPH

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A follow-up study of a cohort of workers from a coke plant compared with a control group from the same industrial area was conducted in 2019. The recruitment and environmental and biomarker measurements were performed during 1993/1994. The environmental concentrations of polycyclic aromatic hydrocarbons (PAH), B(a)P, pyrene and nitro-PAH were measured. Personal data were collected via an individual semi-structured questionnaire by a trained physician. All biomarkers were measured after a specific blood drawing for every test. Significant risks (ORs) were observed for nitro-PAH (≥0.12 µg/m3) [OR = 7.96 (1.01–62.82)], urinary 1-hydroxypyrene (1-OHpy) (≥0.99 µmoles/moles of creatinine) [OR = 11.71 (1.47–92.90)], PAH DNA adducts (P32) (≥2.69 adducts/108 nucleotides) [OR = 5.46 (1.17–25.58)], total nitro-PAH hemoglobin adducts (≥161.68 fg/µg of Hb) [OR = 5.92 (1.26–27.86)], sister chromatid exchange (SCE) with TCR (≥377.84 SCE/cell chromosomes) [OR = 13.06 (3.95–93.10)], sister chromatid exchange with T (≥394.72 total SCE) [OR = 13.06 (3.95–93.10)], and sister chromatid exchange with X (≥8.19 mean SCE) [OR = 13.06 (3.95–93.10)]. Significant risk of death for all causes and chromosomal aberrations (48 h) (OR = 7.19 [1.19–43.44]) or micronuclei in culture at 48 h (OR = 3.86 [1.04–14.38]) were also found.

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Heat-shock protein 70 (HSP70) polymorphisms affect the risk of coke-oven emission-induced neurobehavioral damage

Tian

Li²,

Lyu

et al. 2020

NeuroToxicology

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Interaction of heat shock protein 70 (HSP70) polymorphisms and occupational hazards increases the risk of hypertension in coke oven workers

Abstract: Collectively, these data indicate that HSP70 polymorphisms interact with occupational hazards might increase the risk of hypertension in coke oven workers.

Cited by 6 publications

References 36 publications

HSPA1L rs1061581 polymorphism is associated with the risk of preeclampsia in Han Chinese women

HSPA1L rs1061581 polymorphism is associated with the risk of preeclampsia in Han Chinese women

Environmental Monitoring of PAHs Exposure, Biomarkers and Vital Status in Coke Oven Workers

Heat-shock protein 70 (HSP70) polymorphisms affect the risk of coke-oven emission-induced neurobehavioral damage

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