Interaction of Gender and Age on Post Cardiac Catheterization Contrast-Induced Acute Kidney Injury

Sidhu, R. Bhullar; Brown, Jeremiah R.; Robb, John F.; Jayne, John E.; Friedman, Bruce J.; Hettleman, Bruce; Kaplan, Aaron V.; Niles, Nathaniel W.; Thompson, Craig A.

doi:10.1016/j.amjcard.2008.07.037

Cited by 47 publications

(35 citation statements)

References 11 publications

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“…Females were older but nevertheless had a better outcome of AKI. In contrast, Sidhu et al [26] indicated that elderly women are at particularly high risk for nephrotoxic AKI after cardiac catheterization. The women in our study relatively often suffered from AKI due to dehydration and circulatory insult.…”

Section: Discussionmentioning

confidence: 98%

Clinical Course of Acute Kidney Injury in Elderly Individuals Above 80 Years

Funk

Seibert

Markau

et al. 2016

Kidney Blood Press Res

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Background/Aims: Aging is associated with renal function decline and elderly patients are more vulnerable to acute kidney injury (AKI). The causes and prognosis of AKI according to new KDIGO definition that broadened the diagnosis and included more patients without dialysis dependence have not yet been compared between younger and elderly patients. Methods: In a retrospective analysis all patients with AKI admitted to a tertiary care Nephrology department (N=424) were included. Individuals were stratified by age (≤80 years, >80 years). Primary end-point was death or dialysis dependence at hospital discharge, secondary analyses addressed the need for dialysis, creatinine at discharge, mortality, and length of stay. Results: The distribution of AKI causes was different between the age groups. Circulatory AKI was the most important cause in both groups; however, septic or toxic AKI contributed relevantly in younger patients. Nevertheless, the number of patients reaching the primary end-point was similar (younger, 20.4%; older, 18.0%; OR 1.17, 95%CI, 0.703-1.948). While mortality tended to be higher in the older population, none of the secondary analyses indicated worse outcome for the older patients. Conclusion: The prognosis of AKI in elderly patients is not necessarily worse than in middle aged individuals. Nevertheless, older patients may be particularly vulnerable to circulatory or ischemic insults of the kidneys.

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Section: Discussionmentioning

confidence: 98%

Clinical Course of Acute Kidney Injury in Elderly Individuals Above 80 Years

Funk

Seibert

Markau

et al. 2016

Kidney Blood Press Res

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“…8 On the other hand, the risk of contrast induced acute kidney injury and bleeding due to CAG/PCI is higher in elderly patients. 26 As the rate of non-shockable primary rhythm increases with age, 27 a lower requirement for revascularization may be expected, but even after adjusting for risk factors, acute PCI and administration of fibrinolytic therapy may be relatively underutilized in the elderly. The direct impact of the potential underutilization of acute invasive procedures on mortality cannot be determined in this study design, but the adverse effects of age on mortality and neurological outcome remained unchanged when adjusting for these variables.…”

Section: Post Cardiac Arrest-carementioning

confidence: 99%

Mortality and neurological outcome in the elderly after target temperature management for out-of-hospital cardiac arrest

et al. 2015

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“…Sidhu et al prospectively enrolled 13,127 consecutive patients undergoing coronary angiography who were not on dialysis, and stratified them by age and gender into four age categories (≤50, 51 to 64, 65 to 79, and ≥80 years). Rates of postcatheterization contrast induced AKI, defined as a 25% increase in baseline SC concentration or an overall increase of 0.5 mg/dl, were significantly higher in the group aged ≥80 years (18.7% vs. 15.0%, p=0.048) [53]. A very recent retrospective study assessed the risk of CIN in 1,071 older trauma patients (>55 years of age) undergoing a CT scan [54].…”

Section: Radiocontrast Materialsmentioning

confidence: 98%

Kidney injury: the case of elderly patients

et al. 2011

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approach. AKI treatment in this age group may be even more complex than in the general population. There are data on differences in renal recovery and mortality between the young and the old with renal injury which indicate a higher risk in fragile elderly individuals. Furthermore, it is crucial to establish all possible measures for AKI prevention in the elderly critically ill patient, since once AKI is established, mortality increases significantly.Riassunto Nella popolazione anziana il rischio di danno renale acuto (AKI) è elevato. Il numero di ricoveri di persone anziane in terapia intensiva (ICU) è in crescente aumento e di conseguenza il danno renale acuto acquisito in comunità e in ospedale sta diventando sempre più frequente. Molti cambiamenti legati all'età rendono questi soggetti maggiormente esposti allo sviluppo di insufficienza renale acuta. Talvolta è difficile porre precocemente la diagnosi nell'aziano ricoverato in ICU, e nuovi biomarcatori, come l'ENGAL, posso offrire nuove possibilità. Il trattamento dell'insufficienza renale acuta in questa classe di età può essere anche più complesso che nella popolazione generale. Dati comparativi sul recupero renale e sulla mortalità tra la popolazione giovane e nella terza età dimostrano un maggiore rischio per gli individui anziani fragili. Inoltre, é cruciale definire tutte le possibili misure di prevenzione dell'insufficienza renale acuta nei pazienti critici oltre i 60 anni, poiché una Summary There is a high risk of acute kidney injury (AKI) in the elderly population. The demand for intensive care unit (ICU) admission from older patients is rising, and with it community and hospital acquired AKI are becoming more frequent. Several age-related changes render elderly patients prone to AKI development. The most frequent aetiologies for renal impairment in these patients are recent surgery, sepsis and dehydration. It is sometimes difficult to achieve an early diagnosis in the elderly ICU patient, and new biomarkers such as neutrophil gelatinase-associated lipocalin may offer a new

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Interaction of Gender and Age on Post Cardiac Catheterization Contrast-Induced Acute Kidney Injury

Cited by 47 publications

References 11 publications

Clinical Course of Acute Kidney Injury in Elderly Individuals Above 80 Years

Clinical Course of Acute Kidney Injury in Elderly Individuals Above 80 Years

Mortality and neurological outcome in the elderly after target temperature management for out-of-hospital cardiac arrest

Kidney injury: the case of elderly patients

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