Interaction of dietary methylmercury and selenium on accumulation and retention of these substances in rat organs

Ohi, Gen; Nishigaki, Susumu; Seki, Humitake; Tamura, Y.; Maki, Toshio; Maeda, Hiroko; Ochiai, Setsuko; Yamada, Hiroshi; Shimamura, Yasuhiro; Yagyu, Hiroshi

doi:10.1016/0041-008x(75)90117-9

Cited by 63 publications

(15 citation statements)

References 12 publications

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“…The protective action of sodium selenite against the nephrotoxic effect of inorganic mercury (13,(28)(29)(30)(31)(32)(33)(34) and the beneficial action of selenium in methylmercury poisoning has been described by many authors (33,(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46)(47). Sodium selenite administration results in delayed occurrence of symptoms of neurological and histological disturbances and in enhanced life expectancy of exposed animals (40,43,48).…”

Section: Introductionmentioning

confidence: 99%

“…Selenium has been reported to increase whole-body retention ofmethylmercury (35), increase levels of methylmercury in brain, liver, blood, and spleen while reducing the mercury content at kidneys. The effect on brain, noted by many investigators (41,(49)(50)(51), is of special interest, since no symptoms of intoxication were observed in animals receiving sodium selenite simultaneously with methylmercury, even though the concentration of methylmercury in their brain exceeded critical values (13,15). In other studies simultaneous administration of selenium was reported to result in significant changes in the distribution of methylmercury in the body (34,41,45).…”

Section: Introductionmentioning

confidence: 99%

“…The effect on brain, noted by many investigators (41,(49)(50)(51), is of special interest, since no symptoms of intoxication were observed in animals receiving sodium selenite simultaneously with methylmercury, even though the concentration of methylmercury in their brain exceeded critical values (13,15). In other studies simultaneous administration of selenium was reported to result in significant changes in the distribution of methylmercury in the body (34,41,45). There are also reports stating that if selenium affects the methylmercury concentration in the blood at all, it re-sults in a decrease rather than an increase (52) and that this effect is attributable to a selenium-induced decrease in the affinity of red blood cells for methylmercury (52).…”

Section: Introductionmentioning

confidence: 99%

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Interaction of Alkylmercuric Compounds with Sodium Selenite II. Metabolism of Methylmercuric Chloride Administered Alone and in Combination with Sodium Selenite in Rats

Brzeznicka¹,

Chmielnicka²

1985

Environmental Health Perspectives

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Interaction of Alkylmercuric Compounds with Sodium Selenite II. Metabolism of Methylmercuric Chloride Administered Alone and in Combination with Sodium Selenite in Rats

Brzeznicka¹,

Chmielnicka²

1985

Environmental Health Perspectives

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“…Many studies support the close correlation between Se and cadmium (Cd) or mercury (Hg). [10][11][12][13][14][15][16] Animal experiments have also indicated an interaction between Se and Cd. These experiments show that Se prevents the acute damaging effect of Cd on rat tissues.…”

Section: Introductionmentioning

confidence: 99%

Interrelationship between the Concentration of Toxic and Essential Elements in Korean Tissues.

Yoo

Lee

Yang

et al. 2002

JOURNAL OF HEALTH SCIENCE

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In the past a few decades, particular interest has been focused on the distribution and interaction between toxic and essential elements in animals and humans, since such interactions might have adaptive implications to environmental pollution. The current study was performed to assess the correlation of elemental concentration with age and the correlation between toxic and essential elements in Koreans. Toxic elements, such as Cd, Pb, Hg, and essential elements such as Se and Zn, were analyzed in internal organs (liver, kidney cortex, kidney medulla, heart, lung, spleen, cerebrum, testis and bone) of 162 Korean cadavers. The tissues were digested with a microwave digestion system and the 5 elements were determined by inductively coupled plasma atomic emission spectrometry. Positive correlation with age was observed in the following cases: Cd in the liver, kidney cortex, kidney medulla, heart and testis; Pb in testis and bone. The concentration of Hg, Se and Zn was not correlated with age in any of the tissues tested. A significantly high correlation between Hg and Se, Pb and Se was observed in liver, kidney cortex, kidney medulla, heart, lung, spleen, cerebrum, testis and bone. The correlation between Cd and Zn was significant in the liver, kidney cortex, kidney medulla, heart, lung, cerebrum, testis and bone. These results indicate that the distribution of toxic elements is similar to that of essential elements in all tissues.

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“…Moreover, in the last decade considerable information has been gained on the detoxifying role of sodium selenite in experimental poisoning of animals with mercuric chloride (22)(23)(24)(25)(26)(27)(28) and methylmercury (28)(29)(30)(31)(32)(33)(34)(35).…”

Section: Introductionmentioning

confidence: 99%

Interaction of Alkylmercuric Compounds with Sodium Selenite. I. Metabolism of Ethylmercuric Chloride Administered Alone and in Combination with Sodium Selenite in Rats

Brzeznicka¹,

Chmielnicka²

1981

Environmental Health Perspectives

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The effect of sodium selenite administered intragastrically in repeated doses to rats receiving ethylmercuric chloride po in various repeated doses (0.25 or 2.5 mg Hg/kg) on the excretion, whole-body retention, and organ distribution of mercury was studied.Selenium was found to affect the distribution of ethylmercury among tissues and subcellular fractions of the kidneys and liver as well as its binding to proteins of soluble fractions in these organs.Similarities and differences between the effect of interaction of sodium selenite with ethylmercuric chloride and methylmercury as well as inorganic mercury are also discussed. IntroductionEmployment of alkylmercury compounds, especially methylmercurials, in agriculture has resulted in several epidemic intoxications of humans (1)(2)(3)(4). Ethylmercuric compounds are believed to be generally less toxic due to more rapid clearance (5,6). However, these compounds have been used for a long time not only in agriculture (1, 7) but also as antiseptics, among others for preservation of blood plasma (8).Numerous poisonings by ethylmercurials have been noted, however, in humans (9-13) and in animals (14,15 and concern mainly single-dose experiments (5,10,(16)(17)(18)(19)(20)(21). On the other hand, for estimation of chronic toxicity of alkylmercury compounds, of primary importance is the extent of their accumulation in the body, determined by the magnitude and duration of exposure, uptake rate, biotransformation efficiency and excretion rate.Moreover, in the last decade considerable information has been gained on the detoxifying role of sodium selenite in experimental poisoning of animals with mercuric chloride (22-28) and methylmercury (28-35).According to some authors, in the case of mercuric chloride the mechanism of the detoxifying action of selenium involves a decrease in the renal level of mercury, and therefore a diminution of the nephrotoxic effect (22,24,29,36), the effect of selenite depending on its concentration as well as on the time and kind of exposure (37)(38)(39)(40)(41)(42).Results of studies on the mechanism of protective action of selenium in poisoning by methylmercury 131 compounds are equivocal and sometimes contradictory (27,43 At 24 hr after administration of the last dose of ethylmercuric chloride, rats were sacrificed under ether narcosis by heart puncture and then appropriate organs and tissues were removed.Mercury was estimated directly by a radiochemical method from measurement of gamma-radiation in a USB-2 scintillation counter with a NaI/Tl crystal. The time of measurement was 100 sec.Liver and kidneys were fractionated at a temperature of 0-4°C. The organs were homogenized in 7 volumes of 0.25M sucrose + 0.01% NaOH (pH 7.0) in a glass homogenizer (44). The homogenates were ifitered through a gauze and centrifuged twice at 600g for 15 min to sediment the nuclear fraction (N). The postnuclear supernatant was centrifuged twice at 7000g for 15 min to sediment the mitochondrial fraction (M). The postmitochondrial supernatant was centrifuged once a...

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Interaction of dietary methylmercury and selenium on accumulation and retention of these substances in rat organs

Cited by 63 publications

References 12 publications

Interaction of Alkylmercuric Compounds with Sodium Selenite II. Metabolism of Methylmercuric Chloride Administered Alone and in Combination with Sodium Selenite in Rats

Interaction of Alkylmercuric Compounds with Sodium Selenite II. Metabolism of Methylmercuric Chloride Administered Alone and in Combination with Sodium Selenite in Rats

Interrelationship between the Concentration of Toxic and Essential Elements in Korean Tissues.

Interaction of Alkylmercuric Compounds with Sodium Selenite. I. Metabolism of Ethylmercuric Chloride Administered Alone and in Combination with Sodium Selenite in Rats

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