Interaction of chlorogenic acid with model lipid membranes and its influence on antiradical activity

Cejas, Jimena del Pilar; Rosa, Antonio Sebastián; Nazareno, Mónica A.; Disalvo, E.A.; Frías, María de los Ángeles

doi:10.1016/j.bbamem.2020.183484

“…In the present study, short-term administration of CGA reduced body weight, adipose tissue, and liver weight in db/db mice, although their weight was not comparable to that of control db/m mice. Previous studies have focused on the effects of CGA on gluconeogenesis and fatty acid synthesis ( 24 – 26 ), while our results suggest that CGA enhances hepatic lipolysis and reduces TG synthesis and fatty acid transportation in the liver of db/db mice. In addition, CGA improved the expression of genes involved in hepatic lipid metabolism in high-fat diet (HFD)-fed mice ( 27 ).…”

Section: Discussionmentioning

confidence: 40%

Chlorogenic acid improves glucose tolerance, lipid metabolism, inflammation and microbiota composition in diabetic db/db mice

Yan¹,

Li

²

,

Shen³

et al. 2022

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IntroductionChronic and acute chlorogenic acid (CGA) can improve glucose tolerance (GT) and insulin sensitivity (IS). However, whether acute administration of CGA has beneficial effects on hepatic lipid metabolism and cecal microbiota composition remains unclear.MethodsIn the current study, diabetic db/db mice were administered CGA or metformin, and db/m mice were used as controls to explore the effects of CGA on hepatic lipid metabolism, including fatty acid oxidation and transportation and triglyceride (TG) lipolysis and synthesis. Moreover, alterations in the inflammatory response and oxidative stress in the liver and gut microbe composition were evaluated.ResultsThe results showed that CGA decreased body weight and improved glucose tolerance and insulin resistance, and these effects were similar to those of metformin. CGA decreased hepatic lipid content by increasing the expression of CPT1a (carnitine palmitoyltransferase 1a), ACOX1 (Acyl-CoA oxidase 1), ATGL (adipose triglyceride lipase), and HSL (hormone-sensitive lipase) and decreasing that of MGAT1 (monoacylglycerol O-acyltransferase 1), DGAT1 (diacylglycerol O-acyltransferase), DGAT2, CD36, and FATP4 (fatty acid transport protein 4). Additionally, CGA restored the expression of inflammatory genes, including TNF-α (tumor necrosis factor-alpha), IL-1β (interleukin-1beta), IL-6, and IL-10, and genes encoding antioxidant enzymes, including SOD1 (superoxide dismutases 1), SOD2 (superoxide dismutases 2), and GPX1 (glutathione peroxidase 1). Furthermore, CGA improved the bacterial alpha and beta diversity in the cecum. Moreover, CGA recovered the abundance of the phylum Bacteroidetes and the genera Lactobacillus, Blautia, and Enterococcus.DiscussionCGA can improve the antidiabetic effects, and microbes may critically mediate these beneficial effects.

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“…Plant extracts are good sources of natural immunostimulants attracting much attention in aquaculture [7][8][9], because they have the multiple target effects, excellent biodegrade ability, and few side effects [10][11][12]. Chlorogenic acid (CGA) is a well-known phenolic acid and widely distributed in natural plants, such as honeysuckle, eucommia, chrysanthemum, and sunflower [13]. Numerous studies have demonstrated that CGA have a variety of biological activities, including antioxidant, antibacterial, anti-inflammation, antiglycation, antitumor, and immune regulation [14][15][16], which indicated that it may have potential to maintain the health of animals [17].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Chlorogenic Acid Supplementation in Koi (Cyprinus carpio) Diet: Growth Performance, Body Color, Antioxidant Activity, Serum Biochemical Parameters, and Immune Response

Xu

¹

,

Wang

²

,

Yu

³

et al. 2022

Aquaculture Nutrition

5

1

0

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A ten-week feeding trial was performed to evaluate the effects of chlorogenic acid (CGA) on the growth, body color, antioxidant activity, serum biochemical parameters, and immune response of koi. Five diets were formulated to contain 0 (control), 200 (CGA-2), 400 (CGA-4), 600 (CGA-6), and 800 (CGA-8) mg/kg CGA for the rearing of experimental fish. By means of an analysis by polynomial orthogonal contrasts, it was determined that dietary supplementation with CGA had no significant effects on the growth performance of koi ( P > 0.05 ), while body color indices (redness, yellowness, and lightness) showed a linear order polynomial ( P < 0.05 ). A quadratic response was found for the relationship between total carotenoid in scale of koi and dietary CGA levels, with an optimum level of 381.84 mg/kg. Dietary CGA levels and lysozyme activity showed a cubic relationship polynomial model, with an optimum level of 383.89-975.73 mg/kg. TGF-β expression in the head-kidney of koi was obviously improved by 600 mg/kg CGA diet ( P < 0.05 ). And in regards to effect in serum, SOD and CAT activities was best explicated by a linear order polynomial, while the quadratic and cubic relationship polynomial models represented the GSH and GSH-Px activities, which the optimal supplementation level of CGA was estimated at 550.78 and 231.74-782.66 mg/kg, respectively. The relationship between ALT activity and CGA supplementation was best explicated by quadratic relationship polynomial, with an optimum level of 522.78 mg/kg. Based on the model observed, 522.78-600 mg/kg CGA was the recommended supplementation in diet that improved the body color, antioxidant activity, biochemical parameters, and immune response of koi.

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“…It is recognized that ChA may exert antibacterial effects by altering the permeability of bacterial cell membranes [ 97 ]. Overall, the antibacterial properties of ChA seem to be related to its destructive effects on the bacterial membrane, which disrupts the enzyme and removes iron, a vital element for bacterial growth [ 21 , 23 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of Different Levels of Chlorogenic Acid on Growth Performance, Immunological Responses, Antioxidant Defense, and Disease Resistance of Rainbow Trout (Oncorhynchus mykiss) Juveniles

Ghafarifarsani

¹

,

Nedaei

²

,

Hoseinifar

³

et al. 2023

Aquaculture Nutrition

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The current study is designed to assay the efficacy of chlorogenic acid (ChA) in the diet on growth performance, digestive enzyme activity, serum immunological, biochemical, and antioxidant variables, and mucosal immune response as well as disease resistance of rainbow trout (Oncorhynchus mykiss) juveniles. Rainbow trout juveniles received diets supplemented with different inclusion levels of ChA (0 (ctrl), 200 (CA1), 400 (CA2), 600 (CA3), and 800 (CA4) mg kg−1 diet) for 60 days. According to the findings, fish from CA3 and CA4 groups demonstrated the best results considering the final weight (FW) and weight gain (WG) ( P < 0.05 ). Also, the group that received 600 mg kg−1 ChA-supplemented diet showed the lowest feed conversion ratio (FCR) and the highest specific growth rate (SGR) compared to other groups ( P < 0.05 ). Moreover, the minimum survival rate (SR) was only detected in the CA4 treatment ( P < 0.05 ). Regression analysis exhibited that rainbow trout growth indices were polynomially linked to dietary chlorogenic acid concentrations. In this regard, the optimal levels of chlorogenic acid according to growth parameters (FCR and SGR) were 0.71 and 0.62 gr kg−1 diet, respectively. The results exhibited superior performance of protease and amylase activities in CA2, CA3, and CA4 groups with the maximum amount in the group receiving 600 mg kg−1 ChA-enriched diet ( P < 0.05 ). Serum lysozyme (LYZ), immunoglobulin (Ig), and components 3 and 4 (C3 and C4) values of CA2, CA3, and CA4 groups were significantly higher than others with the highest amount in the CA3 group (P <0.05). Additionally, serum nitroblue tetrazolium (NBT) value in the CA3 and CA4 groups and myeloperoxidase (MPO) in the CA3 group were notably more than others ( P < 0.05 ). Moreover, the lowest aspartate aminotransferase (AST), alkaline phosphatase (ALP), alanine aminotransferase (ALT), and lactate dehydrogenase (LDH) and the highest total protein (TP) and globulin (GLO) values were observed in CA3 treatment ( P < 0.05 ). CA2 and CA3 groups demonstrated increased serum catalase (CAT) and decreased malondialdehyde (MDA) values compared to the control while the highest CAT and lowest MDA values were observed in CA3 treatment ( P < 0.05 ). Considering mucus immunity, the significantly maximum LYZ and protease values were demonstrated in CA2 and CA3 groups, and the highest ALP, Ig, and esterase values were demonstrated in the CA3 group. In comparison with the control, the mortality rates of the groups that received the ChA diets were remarkably ( P < 0.05 ) lower postchallenge with Y. ruckeri, and the highest survival and relative percentage of survival (RPS) ( P < 0.05 ) belonged to the CA3 group. Results obtained from the current study suggested ChA as a functional dietary additive to raise growth parameters, immune indices, antioxidant capacity, and resistance to disease in rainbow trout.

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Interaction of chlorogenic acid with model lipid membranes and its influence on antiradical activity

Cited by 13 publications

References 29 publications

Chlorogenic acid improves glucose tolerance, lipid metabolism, inflammation and microbiota composition in diabetic db/db mice

Chlorogenic acid improves glucose tolerance, lipid metabolism, inflammation and microbiota composition in diabetic db/db mice

Evaluation of Chlorogenic Acid Supplementation in Koi (Cyprinus carpio) Diet: Growth Performance, Body Color, Antioxidant Activity, Serum Biochemical Parameters, and Immune Response

Effect of Different Levels of Chlorogenic Acid on Growth Performance, Immunological Responses, Antioxidant Defense, and Disease Resistance of Rainbow Trout (Oncorhynchus mykiss) Juveniles

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