Abstract:DNA mismatch repair (MMR)2 recognizes and corrects mispaired nucleotides that arise in DNA as a result of errors during DNA replication and chemical damage to DNA and DNA precursors and during the formation of heteroduplex recombination intermediates (1-5). A key early step in MMR is the recognition of the mispaired base in the DNA. In bacteria, mispaired bases are recognized by the MutS homodimer (2, 3, 6 -9). Eukaryotes possess multiple MutS homologs that form two heterodimers, Msh2-Msh6 and Msh2-Msh3, which… Show more
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