Biochemical Pharmacology volume 76, issue 9, P1165-1174 2008 DOI: 10.1016/j.bcp.2008.08.019 View full text
Ursula A. Bussmann, J. Lino Barañao

Abstract: The aryl hydrocarbon receptor (AHR) mediates toxic responses to environmental contaminants and plays pivotal physiological roles in various biological processes as well, particularly in ovarian function. It is well documented that expression and function of the AHR is negatively regulated by transforming growth factor-beta (TGF-beta) in many cell types. In addition, several studies indicate that AHR activity inhibits TGF-beta expression and function in some systems. However, the interplay between these two sig…

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