Interaction between Bacteria and the Immune System for Cancer Immunotherapy: The α-GalCer Alliance

Ustjanzew, Arsenij; Sencio, Valentin; Trottein, François; Faber, Joerg; Sandhoff, Roger; Paret, Claudia

doi:10.3390/ijms23115896

Cited by 8 publications

(3 citation statements)

References 40 publications

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“…Prevotella7 is a specific strain or subgenus of gut microorganisms belonging to the Prevotella genus, and it has previously been recognized for its roles in dietary and intestinal health [ 46 ]. In 2022, Arsenij U et al found Prevotella in mouse glioblastoma tissue and found that Prevotella can produce Alpha-galactosylceramide (α-GalCer), a metabolite that stimulates invariant natural killer T (iNKT) cells to exert anticancer effects [ 47 ]. This finding is consistent with our findings suggesting that increasing the abundance of Prevonella may play a role in immunotherapy for glioblastoma.…”

Section: Discussionmentioning

confidence: 99%

Investigating the causal impact of gut microbiota on glioblastoma: a bidirectional Mendelian randomization study

Zeng,

Zhang,

et al. 2023

BMC Genomics

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Background Currently, the influence of microbiota on the occurrence, progression, and treatment of cancer is a topic of considerable research interest. Therefore, based on the theory of the gut-brain axis proved by previous studies, our objective was to uncover the causal relationship between glioblastoma and the gut microbiome using Mendelian randomization analysis. Methods We conducted a bidirectional Mendelian randomization study using summary statistics of gut microbiota derived from the MiBioGen consortium, the largest database of gut microbiota. Summary statistics for glioblastoma were obtained from IEU OpenGWAS project, which included 91 cases and 218,701 controls. We assessed the presence of heterogeneity and horizontal pleiotropy in the analyzed data. We primarily employed the inverse variance weighting method to investigate the causal relationship between gut microbiota and glioblastoma after excluding cases of horizontal pleiotropy. Four other analysis methods were employed as supplementary. Excluding abnormal results based on leave-one-out sensitivity analysis. Finally, reverse Mendelian randomization analysis was performed. Results Four genus-level taxa and one family-level taxa exhibited causal associations with glioblastoma. And these results of reverse Mendelian randomization analysis shown glioblastoma exhibited causal associations with three genus-level taxa and one family-level taxa. However, the Prevotella7(Forward, P=0.006, OR=0.34, 95%CI:0.158-0.732; Reverse, P=0.004, OR=0.972, 95%CI:0.953-0.991) shown the causal associations with glioblastoma in the bidirectional Mendelian randomization. Conclusions In this bidirectional Mendelian randomization study, we identified five gut microbiota species with causal associations to glioblastoma. However, additional randomized controlled trials are required to clarify the impact of gut microbiota on glioblastoma and to reveal its precise mechanisms.

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Section: Discussionmentioning

confidence: 99%

Investigating the causal impact of gut microbiota on glioblastoma: a bidirectional Mendelian randomization study

Zeng,

Zhang,

et al. 2023

BMC Genomics

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“…Atractylenolide I, a component extracted from Rhizoma Atractylodis macrocephalae, may inhibit dysbacteriosis by regulating TLR4/MyD88/NF-κB signaling 193 . Alpha-galactosylceramide, produced by bacteria such as Bacteroides fragilis, Bacteroides vulgatus, and Prevotella copri, exerts antitumor effects by activating nonconventional T cells, such as invariant natural killer T (iNKT) cells and γδ T cells 194 . AGPs exert chemopreventive effects by restoring dysbiosis and maintaining enteric homeostasis 195 .…”

Section: Treatments Targeting Kras and The Tmementioning

confidence: 99%

Impact of KRAS mutation on the tumor microenvironment in colorectal cancer

Zhou,

Kuang,

Wang

et al. 2024

Int. J. Biol. Sci.

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Kirsten rat sarcoma viral oncogene homolog (KRAS) is an oncogene implicated in the pathophysiology of many cancers. Increasing evidence shows that KRAS mutation is correlated with poor prognosis in numerous cancers, including colorectal cancer (CRC), breast cancer, and melanoma. KRAS also participates in regulating the CRC microenvironment. However, the direct and indirect therapeutic targets of KRAS in CRC have not been identified; thus, elucidating the mechanisms and interactions between KRAS and the tumor microenvironment (TME) in-depth is paramount. Herein, we present some of the major roles KRAS plays in shaping the heterogeneity of the TME and propose a potential strategy for targeting the downstream components of the KRAS signaling pathway and the TME in CRC.

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“…(10/27) were elevated in CF versus controls. The majority of SCFA producing bacteria have been linked to anti-inflammatory and antitumourigenic responses in the colon [27][28][29][30][31][32][33][34][35][36] (Figure 3). SCFA producing bacteria with tumourigenic responses such as Flavonifractor, Dialister, Acidominococcus, B. fragilis, R. gnavus, R. torques were all elevated in CF [28,37,38] (Figure 3).…”

Section: Genus and Species Level Taxonomic Diversitymentioning

confidence: 99%

A systematic review of the colorectal microbiome in adult cystic fibrosis patients

et al. 2023

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Aim Cystic fibrosis (CF) is a hereditary, life‐limiting, multi‐system condition that results in chronic respiratory infections, pancreatic insufficiency and intestinal inflammation. Evidence indicates that CF patients develop colorectal cancer (CRC) earlier and more often than the general population. Intestinal dysbiosis resulting from genetics and CF treatment is a contributing factor. This systematic review aims to evaluate the literature to compare the microbiome of adult CF patients to non‐CF patients and to assess if these changes correspond with known CRC microbiome alterations. Methods A systematic review across five databases was performed according to PRISMA guidelines. Studies focusing on adult CF patients using next generation sequencing and with appropriate non‐CF controls were included. Two reviewers independently screened results and assessed study quality using the Newcastle–Ottawa scale. Results The search generated 2757 results. 118 studies were retained after reviewing the title/abstract and full article review found five studies met the inclusion criteria. All studies consistently showed reduced microbial diversity in CF patients and unique clustering between CF and control cohorts. Thirty‐four genera and 27 species were differently expressed between CF and controls. The CF cohort had a reduced number of short‐chain fatty acid (SCFA) producing bacteria and a higher abundance of bacteria associated with CRC compared to controls. Conclusion There was substantial heterogeneity across all the studies with regard to methodologies and reporting. However, all studies consistently found CF patients had reduced microbial diversity, fewer SCFA producing bacteria and increased CRC‐associated bacteria. Further prospective studies employing consistent multi‐omics approaches are needed to improve our understanding of the CF gut microbiome and its involvement in early onset CRC. Significance statement This is the first systematic review to assess adult CF colorectal microbiome changes. This study shows CF patients have reduced SCFA producing bacteria and increased CRC‐associated bacteria compared to non‐CF patients and may help to explain the increased risk of CRC in the CF cohort.

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Interaction between Bacteria and the Immune System for Cancer Immunotherapy: The α-GalCer Alliance

Cited by 8 publications

References 40 publications

Investigating the causal impact of gut microbiota on glioblastoma: a bidirectional Mendelian randomization study

Investigating the causal impact of gut microbiota on glioblastoma: a bidirectional Mendelian randomization study

Impact of KRAS mutation on the tumor microenvironment in colorectal cancer

A systematic review of the colorectal microbiome in adult cystic fibrosis patients

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