Intensity-modulated radiation therapy for oropharyngeal carcinoma: impact of tumor volume

Chao, K.S. Clifford; Özyiğit, Gökhan; Blanco, Angel I.; Thorstad, Wade L.; Deasy, Joseph O.; Haughey, Bruce H.; Spector, Gershon J.; Sessions, Donald G.

doi:10.1016/j.ijrobp.2003.08.004

Cited by 226 publications

(139 citation statements)

References 34 publications

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“…[4][5][6]10 In contrast to those reports our study population was relatively homogeneous with regard to T and N stage and primary site of disease. In addition, patients in this report who are alive all have been followed for a minimum of 2 years.…”

Section: Discussioncontrasting

confidence: 63%

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Disease-control rates following intensity-modulated radiation therapy for small primary oropharyngeal carcinoma

Garden

Morrison

Wong

et al. 2007

International Journal of Radiation Oncology*Biology*Physics

130

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Section: Discussioncontrasting

confidence: 63%

“…3 Several preliminary clinical experiences have been reported suggesting favorable outcomes for patients treated with IMRT. [4][5][6] This report focuses on a subpopulation of patients with head and neck cancer, specifically those with early T-stage oropharynx cancer, to describe outcomes in a relatively homogenous subgroup.…”

Section: Introductionmentioning

confidence: 99%

Disease-control rates following intensity-modulated radiation therapy for small primary oropharyngeal carcinoma

Garden

Morrison

Wong

et al. 2007

International Journal of Radiation Oncology*Biology*Physics

130

View full text Add to dashboard Cite

show abstract

“…Plataniotis et al [29] found that GTV correlated with treatment outcomes for patients with locally advanced HNSCC treated with radiation therapy or radiation therapy plus chemo therapy. Several authors also reported that GTV obtained from CT scan was a significant predictor for clinical outcome in the treatment of HNSCC [10,[30][31][32]. A few articles suggested that the larger MR-derived GTV was associated with higher recurrence and poorer survival rates [33,34].…”

Section: Discussionmentioning

confidence: 99%

Prognostic Value of Metabolic Tumor Volume Measured by 18F-FDG PET/CT in Locally Advanced Head and Neck Squamous Cell Carcinomas Treated by Surgery

Choi

Yoo

Han

et al. 2010

Nucl Med Mol Imaging

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Purpose We assessed the prognostic value of metabolic tumor volume (MTV) measured using 18 F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) inpatients with locally advanced head and neck squamous cell carcinoma (HNSCC). Methods We retrospectively reviewed 56 patients (51 men, five women; mean age 56.0±8.8years) who had locally advanced HNSCC and underwent FDG PET/CT for initial evaluation. All patients had surgical resection and radiotherapy with or without concurrent chemotherapy. The peak standardized uptake value (SUV peak ) and MTV of the target lesion, including primary HNSCC andmetastatic cervical lymph nodes, were measured from FDG PET/CT images. We compared SUV peak , MTV, and clinicopathologic variables such as age, Eastern Cooperative Oncology Group (ECOG) performance status, pN stage, pT stage, TNM stage, histologic grade and treatment modality to disease-free survival (DFS) and overall survival (OS). Results On the initial FDG PET/CT scans, the median SUV peak was 7.8 (range, 1.8-19.0) and MTV was17.0 cm 3 (range, 0.1-131.0 cm 3 ). The estimated 2-year DFS and OS rates were 67.2% and 81.8%. The cutoff points of SUV peak 6.2 and MTV 20.7 cm 3 were the best discriminative values for predicting clinical outcome. MTV and ECOG performance status were significantly related to DFS and OS on univariate and multivariate analyses (p<0.05). Conclusion The MTV obtained from initial FDG PET/CT scan is a significant prognostic factor for disease recurrence and mortality in locally advanced HNSCC treated with surgery and radiotherapy with or without chemotherapy.

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“…Data are emerging regarding key contributing factors for disease control and treatment failure for H&N IMRT, including tumour characteristics and treatment technique. Chao et al (2004) identified that primary tumour GTV and nodal GTV size independently predicted for therapeutic outcome. Patterns of failure analysis in patients treated with IMRT led Eisbruch et al (2004) to recommend careful attention to retropharyngeal nodes in patients with oropharyngeal primaries.…”

Section: Clinical Applications In Handn Cancermentioning

confidence: 99%

Intensity-modulated radiation therapy: emerging cancer treatment technology

et al. 2005

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The use of intensity-modulated radiation therapy (IMRT) is rapidly advancing in the field of radiation oncology. Intensity-modulated radiation therapy allows for improved dose conformality, thereby affording the potential to decrease the spectrum of normal tissue toxicities associated with IMRT. Preliminary results with IMRT are quite promising; however, the clinical data is relatively immature and overall patient numbers remain small. High-quality IMRT requires intensive physics support and detailed knowledge of threedimensional anatomy and patterns of tumour spread. This review focuses on basic principles, and highlights the clinical implementation of IMRT in head and neck and prostate cancer.

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Intensity-modulated radiation therapy for oropharyngeal carcinoma: impact of tumor volume

Cited by 226 publications

References 34 publications

Disease-control rates following intensity-modulated radiation therapy for small primary oropharyngeal carcinoma

Disease-control rates following intensity-modulated radiation therapy for small primary oropharyngeal carcinoma

Prognostic Value of Metabolic Tumor Volume Measured by 18F-FDG PET/CT in Locally Advanced Head and Neck Squamous Cell Carcinomas Treated by Surgery

Intensity-modulated radiation therapy: emerging cancer treatment technology

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