2016
DOI: 10.1016/j.ijrobp.2016.02.044
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Abstract: Purpose We hypothesized that patients with oropharyngeal cancer treated with intensity-modulated proton therapy (IMPT) would have lower symptom burdens, as measured by patient-reported outcome (PRO) surveys, than patients treated with intensity-modulated photon therapy (IMRT). Methods and Materials Patients were treated for oropharyngeal cancer from 2006 to 2015 through prospective registries with concurrent chemo-IMPT or chemo-IMRT and completed the MD Anderson Symptom Inventory-Head and Neck Cancer (MDASI-… Show more

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Cited by 125 publications
(110 citation statements)
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“…Going forward, the focus will be on determining the optimal deintensified regimen for patients with HPV‐associated OPSCC. The major deintensified strategies are centered around: 1) transoral surgery followed by pathological risk‐adapted reduced dose radiation and chemotherapy; 2) neoadjuvant chemotherapy followed by reduced dose (and possibly volume) radiation; 3) substitution of traditional cytotoxic chemotherapy with targeted therapy (eg, cetuximab); 4) proton therapy; and 5) reduced dose RT and chemotherapy . Each of these paradigms has their own caveats and trade‐offs, with varying degrees of actual deintensification.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Going forward, the focus will be on determining the optimal deintensified regimen for patients with HPV‐associated OPSCC. The major deintensified strategies are centered around: 1) transoral surgery followed by pathological risk‐adapted reduced dose radiation and chemotherapy; 2) neoadjuvant chemotherapy followed by reduced dose (and possibly volume) radiation; 3) substitution of traditional cytotoxic chemotherapy with targeted therapy (eg, cetuximab); 4) proton therapy; and 5) reduced dose RT and chemotherapy . Each of these paradigms has their own caveats and trade‐offs, with varying degrees of actual deintensification.…”
Section: Discussionmentioning
confidence: 99%
“…There are several different approaches that currently are being studied, with varying degrees of actual deintensification. [3][4][5][6][7][8][9] The most common approaches have decreased the radiation dose by either: 1) increasing the chemotherapy dose (ie, the addition of neoadjuvant chemotherapy); or 2) adding primary treatment with transoral surgery. 4,8,10 The limitation of these approaches is that there is little change in the overall intensity of the therapy because they increase the intensity of chemotherapy or surgery to decrease the radiation dose.…”
Section: Introductionmentioning
confidence: 99%
“…In 2005, Slater and colleagues [17] reported the first clinical use of proton therapy in the treatment of oropharyngeal cancer. More recently, the University of Pennsylvania [18], Memorial Sloan Kettering [19], and MD Anderson Cancer Center [20] reported on their experiences with IMPT. The MD Anderson Cancer Center also performed a nonrandomized case-matched analysis with IMRT in a more contemporary setting [21,22].…”
Section: Introductionmentioning
confidence: 99%
“…The need to minimize treatment‐related toxicity must be balanced with the need for treatment efficacy to maintain function and quality of life as well as oncologic control among long‐term survivors. Advances in radiotherapy technology are being sought in an effort to enhance the precision of radiation delivery to avoid treatment‐related toxicity and to allow radiation to be safely combined with molecularly targeted radiation sensitizers or modifiers, all with the ultimate goal of enhancing tumor cell killing and improving tumor control …”
Section: Introductionmentioning
confidence: 99%
“…Strategies to reduce radiation‐related toxicity include the use of proton radiotherapy (PRT), a highly precise radiotherapy modality that has shown promise in the treatment of HNSCC . Because proton beams deliver the greatest dose at the distal edge of their range (via the Bragg peak), PRT theoretically allows delivery of tightly conformal doses to tumors with little or no dose to adjacent normal structures, which presumably would confer better tumor control with less treatment‐related toxicity than XRT …”
Section: Introductionmentioning
confidence: 99%