Journal of Cell Biology volume 217, issue 8, P2799-2812 2018 DOI: 10.1083/jcb.201710022 View full text
ShiHui Wang, ChenYu Wu, YueBin Zhang, QingLu Zhong, Hao Sun, WenPeng Cao, GaoXiang Ge, GuoHui Li, X. Frank Zhang, JianFeng Chen

Abstract: Chemokine (C-C motif) ligand 25 (CCL25) and C-X-C motif chemokine 10 (CXCL10) induce the ligand-specific activation of integrin α4β7 to mediate the selective adhesion of lymphocytes to mucosal vascular addressin cell adhesion molecule-1 (MAdCAM-1) or vascular cell adhesion molecule-1 (VCAM-1). However, the mechanism underlying the selective binding of different ligands by α4β7 remains obscure. In this study, we demonstrate that CCL25 and CXCL10 induce distinct active conformers of α4β7 with a high affinity for…

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