Integrative Medicine and the Long Hauler Syndrome—We Meet Again

Horwitz, Randy; Maizes, Victoria

doi:10.1016/j.amjmed.2020.12.007

Cited by 2 publications

(2 citation statements)

References 7 publications

(4 reference statements)

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“…These cytotoxic tau variants represent a new class of infection‐dependent biomolecules that we incriminate in the tissue injury seen in patients recovering from pneumonia, 58 , 59 critical illness dementia, 16 , 60 , 61 and perhaps the so‐called COVID‐19 long‐haulers. 62 , 63 , 64 …”

Section: Discussionmentioning

confidence: 99%

Pneumonia initiates a tauopathy

et al. 2021

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Pneumonia causes short‐ and long‐term cognitive dysfunction in a high proportion of patients, although the mechanism(s) responsible for this effect are unknown. Here, we tested the hypothesis that pneumonia‐elicited cytotoxic amyloid and tau variants: (1) are present in the circulation during infection; (2) lead to impairment of long‐term potentiation; and, (3) inhibit long‐term potentiation dependent upon tau. Cytotoxic amyloid and tau species were recovered from the blood and the hippocampus following pneumonia, and they were present in the extracorporeal membrane oxygenation oxygenators of patients with pneumonia, especially in those who died. Introduction of immunopurified blood‐borne amyloid and tau into either the airways or the blood of uninfected animals acutely and chronically impaired hippocampal information processing. In contrast, the infection did not impair long‐term potentiation in tau knockout mice and the amyloid‐ and tau‐dependent disruption in hippocampal signaling was less severe in tau knockout mice. Moreover, the infection did not elicit cytotoxic amyloid and tau variants in tau knockout mice. Therefore, pneumonia initiates a tauopathy that contributes to cognitive dysfunction.

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Section: Discussionmentioning

confidence: 99%

Pneumonia initiates a tauopathy

et al. 2021

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“…Indeed, patients with such conditions often lose faith in traditional medicine and turn to complementary and alternative medicine. 30 Most patients come to the clinic after numerous visits with other health care providers and have seen no or minimal improvement. Instead, their symptoms are often blamed on stress and the trauma of the COVID experience.…”

Section: Long Covid and Other Post-viral Illnessesmentioning

confidence: 99%

Addressing the Long COVID Crisis: Integrative Health and Long COVID

Roth

Chan

Jonas

2021

Glob Adv Health Med

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While COVID-19 has killed millions of people globally, its lasting effects on the health and well-being of entire populations are just becoming clear. As many as 30% of those diagnosed with COVID-19 report continuing health-related problems, regardless of the severity of the initial infection. Given the infection rate in the world, that translates to between 5.4 and 17.9 million globally; about 700 000 in the US. The syndrome goes by many names; here we call it “long COVID.” Patients experience a wide range of symptoms, including serious organ system effects such as pulmonary fibrosis, myocarditis, new diabetes diagnoses, stroke, and other cerebrovascular events. They also experience ongoing pain, fatigue, and cognitive dysfunction. We suggest here that these patients require an integrative health approach, one that combines traditional medical management, non-pharmacological approaches, and behavior and lifestyle changes. Such an approach has been shown to be beneficial in other chronic illnesses such as fibromyalgia, chronic fatigue syndrome, and post-Lyme disease.

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Integrative Medicine and the Long Hauler Syndrome—We Meet Again

Cited by 2 publications

References 7 publications

Pneumonia initiates a tauopathy

Pneumonia initiates a tauopathy

Addressing the Long COVID Crisis: Integrative Health and Long COVID

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