Integrative genomic analyses of the histamine H1 receptor and its role in cancer prediction

Wang, Ming-Hai; Wei, Xiaolong; Shi, Lianghui; Chen, Bin; Zhao, Gaoping; Yang, Haiwei

doi:10.3892/ijmm.2014.1649

Cited by 28 publications

(27 citation statements)

References 54 publications

(45 reference statements)

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“…Furthermore, Our results from TCGA-based survival analysis indicated that overexpressed H1HR predicted a poor survival only in HCC patients with high CD68 expression levels, but not in HCC patients with low CD68 expression levels, which further suggested that increased infiltration of myeloid may aggravate the oncogenic effects exerted by H1HR in HCC. However, the relationship between the expression of H1HR and prognosis varied in different cancers, even in the same cancer from different databases [23]. This may be explained by the fact that the function of H1HR in different tumor types may be multidimensional, and it may not simply function as just an oncogene or tumor suppressor.…”

Section: Discussionmentioning

confidence: 99%

Upregulation of histamine receptor H1 promotes tumor progression and contributes to poor prognosis in hepatocellular carcinoma

et al. 2019

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H1 histamine receptor (H1HR) belongs to the family of rhodopsin-like G-protein-coupled receptors. Recent studies have shown that H1HR expression is increased in several types of cancer. However, its functional roles in tumor progression remain largely unknown, especially in hepatocellular carcinoma (HCC). We found that H1HR is frequently unregulated in HCC, which is significantly associated with both recurrence-free survival and overall survival in HCC patients. Functional experiments revealed that H1HR promoted both the growth and metastasis of HCC cells by inducing cell cycle progression, formation of lamellipodia, production of matrix metalloproteinase 2, and suppression of cell apoptosis. Activation of cyclic adenosine monophosphate-dependent protein kinase A was found to be involved in H1HR-mediated HCC cell growth and metastasis. In addition, we found that overexpression of H1HR was mainly due to the downregulation of miR-940 in HCC cells. Moreover, the H1HR inhibitor terfenadine significantly suppressed tumor growth and metastasis in an HCC xenograft nude mice model. Our findings demonstrate that H1HR plays a critical role in the growth and metastasis of HCC cells, which provides experimental evidence supporting H1HR as a potential drug target for the treatment of HCC.

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Section: Discussionmentioning

confidence: 99%

Upregulation of histamine receptor H1 promotes tumor progression and contributes to poor prognosis in hepatocellular carcinoma

et al. 2019

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“…The RNPC1 gene and amino acid sequences were selected from the Ensembl database (http://www.ensembl.org/index.html), based on orthologous and paralogous associations. The selected RNPC1 sequences were applied as queries in order to search for the RNPC1 gene using the BLAST tool at the National Center for Biotechnology Information (NCBI), in order to confirm whether their best hit was an RNPC1 gene (27)(28)(29)(30)(31)(32)(33). The number, length and structure of the exons and introns in the RNPC1 gene in all species were collected from Ensembl.…”

Section: Methodsmentioning

confidence: 99%

Integrative genomic analyses of the RNA-binding protein, RNPC1, and its potential role in cancer prediction

Ding

Yang

Xia

et al. 2015

International Journal of Molecular Medicine

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The RNA binding motif protein 38 (RBM38, also known as RNPC1) plays a pivotal role in regulating a wide range of biological processes, from cell proliferation and cell cycle arrest to cell myogenic differentiation. It was originally recognized as an oncogene, and was frequently found to be amplified in prostate, ovarian and colorectal cancer, chronic lymphocytic leukemia, colon carcinoma, esophageal cancer, dog lymphomas and breast cancer. In the present study, the complete RNPC1 gene was identified in a number of vertebrate genomes, suggesting that RNPC1 exists in all types of vertebrates, including fish, amphibians, birds and mammals. In the different genomes, the gene had a similar 4 exon/3 intron organization, and all the genetic loci were syntenically conserved. The phylogenetic tree demonstrated that the RNPC1 gene from the mammalian, bird, reptile and teleost lineage formed a species-specific cluster. A total of 34 functionally relevant single nucleotide polymorphisms (SNPs), including 14 SNPs causing missense mutations, 8 exonic splicing enhancer SNPs and 12 SNPs causing nonsense mutations, were identified in the human RNPC1 gene. RNPC1 was found to be expressed in bladder, blood, brain, breast, colorectal, eye, head and neck, lung, ovarian, skin and soft tissue cancer. In 14 of the 94 tests, an association between RNPC1 gene expression and cancer prognosis was observed. We found that the association between the expression of RNPC1 and prognosis varied in different types of cancer, and even in the same type of cancer from the different databases used. This suggests that the function of RNPC1 in these tumors may be multidimensional. The sex determining region Y (SRY)-box 5 (Sox5), runt-related transcription factor 3 (RUNX3), CCAAT displacement protein 1 (CUTL1), v-rel avian reticuloendotheliosis viral oncogene homolog (Rel)A, peroxisome proliferator-activated receptor γ isoform 2 (PPARγ2) and activating transcription factor 6 (ATF6) regulatory transcription factor binding sites were identified in the upstream (promoter) region of the RNPC1 gene, and may thus be involved in the effects of RNPC1 in tumors.

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“…ncbi.nlm.nih.gov/Blast.cgi) (15)(16)(17)(18). Conserved transcription factor-binding sites in the promoter regions of the human WTAP gene were identified from the SABiosciences' proprietary database, DECODE (Qiagen, Inc., Valencia, CA, USA), which combines text mining with the University of California, Santa Cruz genome browser data (19)(20)(21).…”

Section: Methodsmentioning

confidence: 99%

“…The functionally relevant SNPs of the human WTAP gene were extracted from the Ensembl genome databases and the Short Genetic Variations database (ncbi.nlm.nih.gov/snp), as previously described (15)(16)(17)(18)(19)(20)(21). The SNPs causing missense mutations were then identified.…”

Section: Identification Of Functionally Relevant Snps In the Human Wtmentioning

confidence: 99%

Identifying the role of Wilms tumor 1 associated protein in cancer prediction using integrative genomic analyses

Qian

Wang

et al. 2016

Molecular Medicine Reports

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The Wilms tumor suppressor, WT1 was first identified due to its essential role in the normal development of the human genitourinary system. Wilms tumor 1 associated protein (WTAP) was subsequently revealed to interact with WT1 using yeast two-hybrid screening. The present study identified 44 complete WTAP genes in the genomes of vertebrates, including fish, amphibians, birds and mammals. The vertebrate WTAP proteins clustered into the primate, rodent and teleost lineages using phylogenetic tree analysis. From 1,347 available SNPs in the human WTAP gene, 19 were identified to cause missense mutations. WTAP was expressed in bladder, blood, brain, breast, colorectal, esophagus, eye, head and neck, lung, ovarian, prostate, skin and soft tissue cancers. A total of 17 out of 328 microarrays demonstrated an association between WTAP gene expression and cancer prognosis. However, the association between WTAP gene expression and prognosis varied in distinct types of cancer, and even in identical types of cancer from separate microarray databases. By searching the Catalogue of Somatic Mutations in Cancer database, 65 somatic mutations were identified in the human WTAP gene from the cancer tissue samples. These results suggest that the function of WTAP in tumor formation may be multidimensional. Furthermore, signal transducer and activator of transcription 1, forkhead box protein O1, interferon regulatory factor 1, glucocorticoid receptor and peroxisome proliferator-activated receptor γ transcription factor binding sites were identified in the upstream (promoter) region of the human WTAP gene, suggesting that these transcription factors may be involved in WTAP functions in tumor formation.

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Integrative genomic analyses of the histamine H1 receptor and its role in cancer prediction

Cited by 28 publications

References 54 publications

Upregulation of histamine receptor H1 promotes tumor progression and contributes to poor prognosis in hepatocellular carcinoma

Upregulation of histamine receptor H1 promotes tumor progression and contributes to poor prognosis in hepatocellular carcinoma

Integrative genomic analyses of the RNA-binding protein, RNPC1, and its potential role in cancer prediction

Identifying the role of Wilms tumor 1 associated protein in cancer prediction using integrative genomic analyses

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