2018
DOI: 10.20944/preprints201810.0733.v1
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Abstract: Prefrontal cortex (PFC) is one of the brain regions with more prominent changes in human aging. The molecular processes related to the aging cognitive decline and mood changes are not completely understood. In order to improve our knowledge, we integrated transcriptomic data of four studies of human PFC from old people -58-80 years old- compared with young people -20-40 years old- using a meta-analytic approximation combined with molecular signature analysis. We identified 1816 differentially expressed genes -… Show more

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Cited by 2 publications
(4 citation statements)
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“…Viral load in COVID-19 patients also correlates highly with serum IFN-γ levels [ 251 ], and those requiring intensive care treatment have high serum IFN-γ levels [ 253 ]. This cytokine can similarly stimulate neurotoxic reactive astrocyte activation [ 227 ], and IFNGR1 expression is upregulated in reactive astrocytes during CNS prion disease [ 213 ], in aging human brains and patients with Parkinson’s disease and Alzheimer’s disease [ 227 , 254 ]. Thus, it is plausible that the systemic production of high levels of pro-inflammatory mediators such as TNF-α and IFN-γ in response to infection with the SARS-Cov-2 virus could accelerate the neurodegeneration in patients with concurrent prion disease or other neurodegenerative disorders.…”
Section: Cns Prion Diseasementioning
confidence: 99%
“…Viral load in COVID-19 patients also correlates highly with serum IFN-γ levels [ 251 ], and those requiring intensive care treatment have high serum IFN-γ levels [ 253 ]. This cytokine can similarly stimulate neurotoxic reactive astrocyte activation [ 227 ], and IFNGR1 expression is upregulated in reactive astrocytes during CNS prion disease [ 213 ], in aging human brains and patients with Parkinson’s disease and Alzheimer’s disease [ 227 , 254 ]. Thus, it is plausible that the systemic production of high levels of pro-inflammatory mediators such as TNF-α and IFN-γ in response to infection with the SARS-Cov-2 virus could accelerate the neurodegeneration in patients with concurrent prion disease or other neurodegenerative disorders.…”
Section: Cns Prion Diseasementioning
confidence: 99%
“…Genes identified as hub genes in the coexpression networks were validated against the results of a meta-analysis of four independent transcriptomics studies on human pfc in which the transcriptomes of persons between 60 and 80 years old with persons between 20 and 40 years old were compared for deg identification (15).…”
Section: Validation Of Hub Genes For Coexpression Networkmentioning
confidence: 99%
“…As an external validation of the results, the expression change direction of the hub genes was compared with the results of a meta-analysis in which four independent studies different to the one used in the present research were integrated, these characterized the transcriptomic response to aging in the pfc (15). Of the five identified hub genes, three were analyzed in the meta-analysis -ca10, plppr4, cryab-and all of them presented the same direction of change found in this study, the first two repressed, and the third one, overexpressed.…”
Section: Development Of the Weighted Coexpression Networkmentioning
confidence: 99%
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