2020
DOI: 10.3892/mmr.2020.10955
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Abstract: long non-coding rnas (lncrnas) are a group of non-coding transcripts of >200 nucleotides. They can act as competing endogenous rnas (cernas) and suppress microrna (mirna) function by preventing them from binding to and interacting with target mrnas. However, the specific role of the lncRNA-associated ceRNA network in the pathogenesis of glaucoma has not yet been elucidated. To study this, data were downloaded from the Gene expression omnibus database (GSe126170), which contained three human trabecular meshwork… Show more

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Cited by 9 publications
(17 citation statements)
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“…TGF-β2 promotes fibronectin expression [ 114 ] through miR-29b inhibition (increases collagen types I and IV) and the SMAD signaling pathway [ 115 ]. ROS in TM cells induces ECM deposition, which promotes cellular senescence, injury, and apoptosis [ 116 , 117 ]. miR-29b is significantly down-regulated in TM cells, associated with ECM deposition caused by oxidative stress.…”
Section: Mechanisms Of Mirnas In Poagmentioning
confidence: 99%
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“…TGF-β2 promotes fibronectin expression [ 114 ] through miR-29b inhibition (increases collagen types I and IV) and the SMAD signaling pathway [ 115 ]. ROS in TM cells induces ECM deposition, which promotes cellular senescence, injury, and apoptosis [ 116 , 117 ]. miR-29b is significantly down-regulated in TM cells, associated with ECM deposition caused by oxidative stress.…”
Section: Mechanisms Of Mirnas In Poagmentioning
confidence: 99%
“…Additionally, appropriate oxidative stress biomarkers in AH of POAG patients should be further examined, focusing on the AH-producing cells and the non-pigmented ciliary epithelium (NPCE) located in the anterior chamber of the eye, exiting the eye through the TM cells in the conventional pathway [ 30 ]. A potential therapeutic target for glaucoma can be achieved by suppression of miRNAs that are considered as pro-mediators of oxidative stress, such as miR-210, using long non-coding RNAs transcripts (lncRNAs) [ 117 ]. In conclusion, we suggest further investigating the role of POAG-related miRNAs as antioxidant machinery, examining their dual role as pro- or anti-inflammatory/apoptotic agents as a response to diverse concentrations of ROS in TM cells and RGC.…”
Section: Concluding Remarks and Future Perspectivesmentioning
confidence: 99%
“…SNHG3 has been reported to regulate a variety of diseases, such as hepatocellular carcinoma 29 and osteosarcoma 30 . Notably, SNHG3 has been found to be related to neurodegeneration 31 , and it has been reported to be upregulated in H 2 O 2 -induced HTM cells 32 . In the present study, our data revealed that SNHG3 was upregulated in H 2 O 2 -induced HTM cells and SNAI2 (snail family transcriptional repressor 2) is also known as SLUG, SLUGH, SLUGH1, SNAIL2, or WS2D; it has been reported to regulate a wide range of human diseases [38][39][40] .…”
Section: Snai2 Overexpression Counteracted the Effect Of Snhg3 Silencmentioning
confidence: 99%
“…DNA damage is related to various neurodegenerative diseases, including glaucoma 32,33 . In comparison with healthy controls, oxidative DNA damage is distinctly increased in the TM of patients with glaucoma 32 .…”
Section: Introductionmentioning
confidence: 99%
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