Current Opinion in Hematology volume 19, issue 3, P184-191 2012 DOI: 10.1097/moh.0b013e3283523ea6 View full text
Shayn M. Peirce, Feilim Mac Gabhann, Victoria L. Bautch

Abstract: Purpose of review We summarize recent experimental and computational studies that investigate molecular and cellular mechanisms of sprouting angiogenesis. We discuss how experimental tools have unveiled new opportunities for computational modeling by providing detailed phenomenological descriptions and conceptual models of cell-level behaviors underpinned by high-quality molecular data. Using recent examples, we show how new understanding results from bridging computational and experimental approaches. Rec…

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