Integration of electrochemistry in micro-total analysis systems for biochemical assays: Recent developments

Xu, Xiaoli; Zhang, Song; Chen, Hui; Kong, Jilie

doi:10.1016/j.talanta.2009.06.039

Cited by 110 publications

(85 citation statements)

References 166 publications

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“…16 Within the Lab-on-a-Chip systems field, extensive work has been done in integrating electrochemical detection. [17][18][19][20][21] However, despite the previously mentioned advantages of having electric contact to a microfluidic system, only few examples of centrifugal microfluidic platforms interfaced with electrical connections have been reported in the literature. [22][23][24][25][26] These examples are based on one of two different options:…”

Section: Introductionmentioning

confidence: 99%

Integrating electrochemical detection with centrifugal microfluidics for real-time and fully automated sample testing

et al. 2015

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Abstract. Here we present a robust, stable and low-noise experimental set-up for performing electrochemical detection on a centrifugal microfluidic platform. By using a low-noise electronic component (electrical slipring) it is possible to achieve continuous, on-line monitoring of electrochemical experiments, even when the microfluidic disc is spinning at high velocities. Automated sample handling is achieved by designing a microfluidic system to release analyte sequentially, utilizing on-disc passive valving. In addition, the microfluidic system is designed to trap and keep the liquid sample stationary during analysis. In this way it is possible to perform cyclic voltammetry (CV) measurements at varying spin speeds, without altering the electrochemical response. This greatly simplifies the interpretation and quantification of data. Finally, real-time and continuous monitoring of an entire electrochemical experiment, including all intermediate sample handling steps, is demonstrated by amperometric detection of on-disc mixing of analytes (PBS and ferricyanide).

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Section: Introductionmentioning

confidence: 99%

Integrating electrochemical detection with centrifugal microfluidics for real-time and fully automated sample testing

et al. 2015

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“…Because there are many beneficial size effects at the micro and nano scales, such as short mixing times, high efficiency in chemical reactions, and minute amounts of reagents and effluent liquids, micro/nano fluidic devices have been extensively studied for use in biomedical applications [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]. In particular, nano fluidic devices that contain nano channels can be used for separation and filtration [21], single-molecule detection [22][23][24][25][26], highly efficient PCR [27], chemical analysis [28,29] and nano-photonic sensors [30], with great help of development of nanofabrication technologies [31][32][33][34][35][36][37][38][39][40][41][42][43].…”

Section: Introductionmentioning

confidence: 99%

Effects of Micromachining Processes on Electro-Osmotic Flow Mobility of Glass Surfaces

et al. 2013

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Silica glass is frequently used as a device material for micro/nano fluidic devices due to its excellent properties, such as transparency and chemical resistance. Wet etching by hydrofluoric acid and dry etching by neutral loop discharge (NLD) plasma etching are currently used to micromachine glass to form micro/nano fluidic channels. Electro-osmotic flow (EOF) is one of the most effective methods to drive liquids into the channels. EOF mobility is affected by a property of the micromachined glass surfaces, which includes surface roughness that is determined by the manufacturing processes. In this paper, we investigate the effect of micromaching processes on the glass surface topography and the EOF mobility. We prepared glass surfaces by either wet etching or by NLD plasma etching, investigated the surface topography using atomic force microscopy, and attempted to correlate it with EOF generated in the micro-channels of the machined glass. Experiments revealed that the EOF mobility strongly depends on the surface roughness, and therefore upon the fabrication process used. A particularly strong dependency was observed when the surface roughness was on the order of the electric double layer thickness or below. We believe that the correlation described in this paper can be of great help in the design of micro/nano fluidic devices.

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“…These electrochemical array devices provide several important advantages, including rapid response time and the ability to perform both qualitative and quantitative analyses. 46,47 Electrochemical sensors are incorporated into theses devices in order to achieve multipoint detection. However, as mentioned in the previous section, it is difficult to incorporate a large number of electrochemical sensors into a small device.…”

Section: Electrochemical Imaging and High-throughput Analysismentioning

confidence: 99%

Microchemistry- and MEMS-based Integrated Electrochemical Devices for Bioassay Applications

Ino

2015

Electrochemistry

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Here, we present an overview of our recent research progress in development of electrochemical devices/systems for bioassays. These devices/systems are based on microchemistry and micro-electromechanical systems (MEMS) for sophisticated analytical and electrochemical measurements. In particular, we exploit the unique chemical reactions occurring in micrometer-size spaces and/or involving micrometer-size structures for bioassays, including cell analyses. This paper addresses five topics: probe-, chip-, large-scale-integration chip-, and dielectrophoresisbased devices, and electrodeposition of hydrogels for bioassays.

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Integration of electrochemistry in micro-total analysis systems for biochemical assays: Recent developments

Cited by 110 publications

References 166 publications

Integrating electrochemical detection with centrifugal microfluidics for real-time and fully automated sample testing

Integrating electrochemical detection with centrifugal microfluidics for real-time and fully automated sample testing

Effects of Micromachining Processes on Electro-Osmotic Flow Mobility of Glass Surfaces

Microchemistry- and MEMS-based Integrated Electrochemical Devices for Bioassay Applications

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