Integrating electric field modeling and neuroimaging to explain inter-individual variability of tACS effects

Kasten, Florian H.; Duecker, Katharina; Maack, Marike C.; Meiser, Arnd; Herrmann, Christoph S.

doi:10.1038/s41467-019-13417-6

Cited by 155 publications

(225 citation statements)

References 69 publications

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“…We compared differences in error rates between congruent and incongruent trials for the different stimulation conditions whilst controlling for dose dependent effects of tACS (‘tACS-dose’) ( Evans et al, 2020 ; Kasten et al, 2019 ). tACS-dose was estimated by taking BOLD contrast between stimulation and sham conditions extracted from right aPFC ( Evans et al, 2020 ).…”

Section: Methodsmentioning

confidence: 99%

Improving emotional-action control by targeting long-range phase-amplitude neuronal coupling

Bramson

Ouden

Toni

et al. 2020

eLife

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Control over emotional action tendencies is essential for everyday interactions. This cognitive function fails occasionally during socially challenging situations, and systematically in social psychopathologies. We delivered dual-site phase-coupled brain stimulation to facilitate theta-gamma phase-amplitude coupling between frontal regions known to implement that form of control, while neuropsychologically healthy human male participants were challenged to control their automatic action tendencies in a social–emotional approach/avoidance-task. Participants had increased control over their emotional action tendencies, depending on the relative phase and dose of the intervention. Concurrently measured fMRI effects of task and stimulation indicated that the intervention improved control by increasing the efficacy of anterior prefrontal inhibition over the sensorimotor cortex. This enhancement of emotional action control provides causal evidence for phase-amplitude coupling mechanisms guiding action selection during emotional-action control. Generally, the finding illustrates the potential of physiologically-grounded interventions aimed at reducing neural noise in cerebral circuits where communication relies on phase-amplitude coupling.

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Section: Methodsmentioning

confidence: 99%

Improving emotional-action control by targeting long-range phase-amplitude neuronal coupling

Bramson

Ouden

Toni

et al. 2020

eLife

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“…3E). Although adapting tACS protocols to individual participants has been suggested as a crucial step to increase effect sizes and advance the field (25)(26)(27), neural parameters that can predict these individual differences remain elusive. Here, we report an analysis of combined data from 18 participants who participated in both our experiments.…”

Section: Experiments 1 Vs 2: Phase Of Speech-entrained Eeg Predicts Tamentioning

confidence: 99%

“…For example, there is typically no consistent tACS phase which leads to highest perceptual accuracy for all participants (7)(8)(9)(10). Individualizing brain stimulation protocols has therefore been proposed as a crucial step to advance the theoretical and practical application of this line of research (25)(26)(27). A recent study (59) reported that the phase relation between tACS and visual flicker modulates the magnitude of EEG responses to the flicker when tACS is turned off.…”

Section: Predicting Tacs Outcomes From Eeg Dataimplications For Futurmentioning

confidence: 99%

Sustained neural rhythms reveal endogenous oscillations supporting speech perception

Bree

Sohoglu

Davis

et al. 2020

Preprint

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Rhythmic sensory or electrical stimulation will produce rhythmic brain responses. These rhythmic responses are often interpreted as endogenous neural oscillations aligned to the stimulus rhythm. However, stimulus-aligned brain responses can also be explained as a sequence of evoked responses, which only appear regular due to the rhythmicity of the stimulus, without necessarily involving underlying neural oscillations. To distinguish evoked responses from true oscillatory activity, we tested whether rhythmic stimulation produces oscillatory responses which continue after the end of the stimulus. Such sustained effects provide evidence for true involvement of neural oscillations. In Experiment 1, we found that rhythmic intelligible, but not unintelligible speech produces oscillatory responses in magnetoencephalography (MEG) which outlast the stimulus at parietal sensors. In Experiment 2, we found that transcranial alternating current stimulation (tACS) leads to rhythmic fluctuations in speech perception outcomes which continue after the end of electrical stimulation. We further report that the phase relation between electroencephalography (EEG) and rhythmic intelligible speech can predict the tACS phase that leads to most accurate speech perception. Together, our results lay the foundation for a new account of speech perception which includes endogenous neural oscillations as a key underlying principle.

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“…However, individualized tACS parameters might be more effective. Future studies might therefore consider the participant's individual anatomy as well as the individual peak frequency of the targeted neural oscillations [12,20]. In addition, increasing tACS intensity, duration, and/or perform repeated stimulation sessions might increase its neural efficacy.…”

Section: Discussionmentioning

confidence: 99%

Modulating Brain Rhythms of Pain using Transcranial Alternating Current Stimulation (tACS)? A Sham-controlled Study in Healthy Human Participants

E¹,

Hohn²,

Nickel³

et al. 2020

Preprint

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Pain protects the body. However, pain can also occur for longer periods without serving protective functions. Such chronic pain conditions are difficult to treat. Thus, a better understanding of the underlying neural mechanisms and new approaches for the treatment of pain are urgently needed. Here, we investigated a causal role of oscillatory brain activity for pain and explored the potential of transcranial alternating current stimulation (tACS) as a new treatment approach for pain. To this end, we investigated whether tACS can modulate pain and pain-related autonomic activity in 29 healthy human participants using a tonic heat pain paradigm as an experimental model of chronic pain. In 6 recording sessions, participants received tACS over prefrontal or somatosensory cortices at alpha or gamma frequencies or sham tACS. During tACS, pain ratings and autonomic responses were collected. TACS did not modulate pain intensity, the stability of pain ratings or the translation of the noxious stimulus into pain. Likewise, tACS did not change autonomic responses. Bayesian statistics further indicated a lack of tACS effects in most conditions. The only exception was alpha tACS over somatosensory cortex where evidence for tACS effects was inconclusive. Taken together, the present study did not find significant tACS effects on tonic experimental pain in healthy human participants. However, considering the conceptual plausibility of using tACS to modulate pain and the urgent need for novel pain treatments, further tACS studies are warranted. Based on the present findings, such studies might apply refined stimulation protocols targeting alpha oscillations in somatosensory cortices.

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Integrating electric field modeling and neuroimaging to explain inter-individual variability of tACS effects

Cited by 155 publications

References 69 publications

Improving emotional-action control by targeting long-range phase-amplitude neuronal coupling

Improving emotional-action control by targeting long-range phase-amplitude neuronal coupling

Sustained neural rhythms reveal endogenous oscillations supporting speech perception

Modulating Brain Rhythms of Pain using Transcranial Alternating Current Stimulation (tACS)? A Sham-controlled Study in Healthy Human Participants

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