Integrated transcriptomic landscape of the effect of anti‐steatotic treatments in high‐fat diet mouse models of non‐alcoholic fatty liver disease
Isabel Fuster‐Martínez,
José F Català‐Senent,
Marta R Hidalgo
et al.
Abstract:High‐fat diet (HFD) mouse models are widely used in research to develop medications to treat non‐alcoholic fatty liver disease (NAFLD), as they mimic the steatosis, inflammation, and hepatic fibrosis typically found in this complex human disease. The aims of this study were to identify a complete transcriptomic signature of these mouse models and to characterize the transcriptional impact exerted by different experimental anti‐steatotic treatments. For this reason, we conducted a systematic review and meta‐ana… Show more
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