Integrated POSS-dendrimer nanohybrid materials: current status and future perspective

Zhan, Li; Hu, Junfei; Yang, Lei; Zhang, Xueqian; Liu, Xianhu; Wang, Zhao; Li, Yiwen

doi:10.1039/d0nr02394a

Cited by 60 publications

(44 citation statements)

References 137 publications

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“…Various synthesis routes have been applied to prepare dendrons and dendrimers, which have been covered in detail in previous reviews (Z. Li, Hu, et al, 2020; Lyu, Ding, Huang, Kao, & Peng, 2019). Their synthesis methods can be classified into two main routes, namely, divergent and convergent (Figure 2).…”

Section: Classification and Preparation Of Dendritic Polymersmentioning

confidence: 99%

Recent advances in development of dendritic polymer‐based nanomedicines for cancer diagnosis

Sun

Zhu

et al. 2020

WIREs Nanomed Nanobiotechnol

172

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Dendritic polymers have highly branched three‐dimensional architectures, the fourth type apart from linear, cross‐linked, and branched one. They possess not only a large number of terminal functional units and interior cavities, but also a low viscosity with weak or no entanglement. These features endow them with great potential in various biomedicine applications, including drug delivery, gene therapy, tissue engineering, immunoassay and bioimaging. Most review articles related to bio‐related applications of dendritic polymers focus on their drug or gene delivery, while very few of them are devoted to their function as cancer diagnosis agents, which are essential for cancer treatment. In this review, we will provide comprehensive insights into various dendritic polymer‐based cancer diagnosis agents. Their classification and preparation are presented for readers to have a precise understanding of dendritic polymers. On account of physical/chemical properties of dendritic polymers and biological properties of cancer, we will suggest a few design strategies for constructing dendritic polymer‐based diagnosis agents, such as active or passive targeting strategies, imaging reporters‐incorporating strategies, and/or internal stimuli‐responsive degradable/enhanced imaging strategies. Their recent applications in in vitro diagnosis of cancer cells or exosomes and in vivo diagnosis of primary and metastasis tumor sites with the aid of single/multiple imaging modalities will be discussed in great detail. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease Diagnostic Tools > in vivo Nanodiagnostics and Imaging Diagnostic Tools > in vitro Nanoparticle‐Based Sensing

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Section: Classification and Preparation Of Dendritic Polymersmentioning

confidence: 99%

Recent advances in development of dendritic polymer‐based nanomedicines for cancer diagnosis

Sun

Zhu

et al. 2020

WIREs Nanomed Nanobiotechnol

172

View full text Add to dashboard Cite

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“…The reaction active sites of POSS molecules were considered as 8, indicating that the core multiplicity was much larger than usual smaller molecular inner cores (2—4) in dendritic structures. [ 92 ] Hence, POSS dendrimers were designed to form high generation of POSS dendrimers with more surface functionalities as their proportionality for core multiplicity. Moreover, eight peripheral organic groups could be further functionalized as a wide variety of groups such as amino, vinyl and hydroxyl, which provide benefits on construction of different kinds of POSS‐based hybrid materials.…”

Section: Molecular Design Of Poss‐based Hybrid Materialsmentioning

confidence: 99%

“…[ 91 ] In general, dendritic materials consisted of dendrimers and hyperbranched polymers with three main parts: inner core moiety, repeating unit and surface terminal functional groups. [ 92 ] The unique properties of dendritic materials, including defined unimolecular architecture, high branching degrees, exact molecular weight and multi‐functional external groups, provided benefits on construction of hybrid materials as building blocks. However, the desired high‐density functional groups of high generation of dendrimers required a series of complicated synthetic steps and separation procedure, resulting in low yields and…”

Section: Molecular Design Of Poss‐based Hybrid Materialsmentioning

confidence: 99%

“…The increased content of inorganic silicon compound could improve the thermal stability and mechanical strength of hybrid materials. [ 92 ] Compared with POSS‐core dendrimers, employing POSS as repeating unit could significantly improve POSS content since POSS itself possesses high branching multiplicity of 7. Wang et al .…”

Section: Molecular Design Of Poss‐based Hybrid Materialsmentioning

confidence: 99%

“…Owing to the eight amino substituents at corner of Si‐O skeleton, multifunctional POSS could achieve versatile chemical modifications, including Michael addition reaction and condensation. [ 92 ] As regards these POSS‐based dendrimers, several works had been reported for synthetic routes and related applications. For instance, Huang et al .…”

Section: Molecular Design Of Poss‐based Hybrid Materialsmentioning

confidence: 99%

See 2 more Smart Citations

Polyhedral Oligomeric Silsesquioxanes (POSS)‐based Hybrid Materials: Molecular Design, Solution Self‐Assembly and Biomedical Applications

Fan

Wang

2021

Chin. J. Chem.

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Owing to the tremendous advantages and unique well‐defined nanoscale structure, polyhedral oligomeric silsesquioxanes (POSS) have received considerable interest in the design of novel organic‐inorganic hybrid nanomaterials with all manner of prominent capabilities, which is recognized as a new generation of promising materials for advanced applications of material science, engineering science and biomedical fields. Benefitting from the recent progress in combination of controlled/living polymerization and emerging click chemistry, POSS‐based hybrid materials with ingenious design, versatile topological structure and sophisticated multifunctionality have been successfully fabricated and developed into abundant well‐defined hybrid nanostructures with desired physicochemical properties. Tailor‐made amphiphilic molecular design and nanosized hybrid architecture provide opportunities for the self‐assembly of POSS‐based hybrid materials with unique hierarchical morphologies in selective solvents. Through the in‐depth understanding of structure‐properties relationship, POSS‐based hybrid materials can achieve the modulation of precise control of self‐assembling process and multi‐purpose applications with improved material performances. In this review, we summarize the recent advances of POSS‐based hybrid materials in molecular design, self‐assembly behavior in solutions and potential biomedical applications with main concerns on drug delivery, gene therapy, bioimaging and tissue engineering field. Finally, future directions and remaining challenges for further advancement of POSS‐based hybrid materials are proposed and discussed.

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The Role of Polyhedral Oligomeric Silsesquioxanes in Optical Applications

Tunstall-Garcia

Charles

Evans

2021

Advanced Photonics Research

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The popularity of polyhedral oligomeric silsesquioxanes (POSS) for use in hybrid organic–inorganic materials and devices has grown in the past two decades due to desirable properties such as good thermal stability and biocompatibility, as well as their potential to be functionalized for a wide range of applications, from polymer composites to optoelectronics. Herein, the role of POSS for photonic applications, including sensing, bioimaging, and optoelectronic devices, is summarized. Functionalized POSS building blocks commonly incorporated with luminescent materials are identified, and areas of potential growth within the field are discussed. The addition of POSS to light‐emitting materials is widely shown to prevent aggregation in organic lumophores and inorganic nanocrystals, leading to reduced photoluminescence quenching. The POSS unit is also capable of acting as a passivating agent for nanocrystals and thin films, improving the emission quantum yields of photoluminescent materials and devices. POSS therefore offers the potential to enhance both the functional and photonic properties of cutting‐edge hybrid technologies.

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Integrated POSS-dendrimer nanohybrid materials: current status and future perspective

Abstract: This review summarizes POSS-dendrimer nanohybrid materials, focusing on their synthesis strategies, adjustable macroscopic properties, and potential applications. Moreover, their current trends, challenges and future directions are also elaborated.

Cited by 60 publications

References 137 publications

Recent advances in development of dendritic polymer‐based nanomedicines for cancer diagnosis

Recent advances in development of dendritic polymer‐based nanomedicines for cancer diagnosis

Polyhedral Oligomeric Silsesquioxanes (POSS)‐based Hybrid Materials: Molecular Design, Solution Self‐Assembly and Biomedical Applications

The Role of Polyhedral Oligomeric Silsesquioxanes in Optical Applications

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