2020
DOI: 10.3389/fimmu.2020.612784
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Abstract: The ETS family modulates immune response and drug efficiency to targeted therapies, but their role in melanoma is largely unclear. In this study, the ETS family was systematically analyzed in multiple public data sets. Bioinformatics tools were used to characterize the function of ETV7 in melanoma. A prognostic model was constructed using the LASSO Cox regression method. We found that ETV7 was the only differentially expressed gene with significant prognostic relevance in melanoma. Enrichment analysis of seven… Show more

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Cited by 17 publications
(17 citation statements)
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“…For example, we found that ETV7 exhibited higher expression in 13 cancer types ( Supplementary Figure S6A ) and potentially regulate TCR signaling pathway in several cancers (Figure 3B). Previous study has demonstrated that ETV7 particularly showed a strong positive correlation with CD8 + T cell infiltration in melanoma ( 59 ). Several studies have determined singling cascades associated with miR-146a-5p, such as toll-like receptor pathway and ErB pathway ( 60 ).…”
Section: Resultsmentioning
confidence: 86%
“…For example, we found that ETV7 exhibited higher expression in 13 cancer types ( Supplementary Figure S6A ) and potentially regulate TCR signaling pathway in several cancers (Figure 3B). Previous study has demonstrated that ETV7 particularly showed a strong positive correlation with CD8 + T cell infiltration in melanoma ( 59 ). Several studies have determined singling cascades associated with miR-146a-5p, such as toll-like receptor pathway and ErB pathway ( 60 ).…”
Section: Resultsmentioning
confidence: 86%
“…Patients were divided into two subgroups based on the optimal cut-off value of the risk score via the surv_cutpoint function of the survminer package (R software, version 3.6). Univariate and multivariate Cox regression, survival analyses and timedependent receiver operator characteristic (ROC) analyses were conducted as reported in our previous study (Qu et al, 2020). Significance of difference was indicated as * P < 0.05; * * P < 0.01; * * * P < 0.001; * * * * P < 0.0001.…”
Section: Discussionmentioning
confidence: 99%
“…Gene ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis and gene set enrichment analysis (GSEA) were conducted as reported in our previous studies (Yu et al, 2012;Qu et al, 2020;Zhang et al, 2020).…”
Section: Bioinformatics Analysismentioning
confidence: 99%
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“…The tumor purity was estimated by the following formula: Tumor_purity = cos (0.6049872018 + 0.0001467884*ESTIMATEScore). The infiltration of immune cells was evaluated by the ssGSEA and TIMER algorithms, as reported in our previous study [ 16 , 17 ].…”
Section: Methodsmentioning
confidence: 99%