Intake and absorption of nutrients in children with cholera and rotavirus infection during acute diarrhea and after recovery

Molla, A; Molla, Ayesha; Rahim, Abdur; Sarker, Shafiqul Alam; Mozaffar, Zahid; Rahaman, M. Mujibur

doi:10.1016/s0271-5317(82)80004-3

Cited by 36 publications

(15 citation statements)

References 13 publications

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“…In children recovering from severe malnutrition precipitated by infection, malabsorption of fat and carbohydrate persisted for 4 to 6 months after apparent complete recovery from malnutrition. 24,25 In addition, between 30% and 50% of individuals living in an unsanitary environment experience so-called tropical jejunitis or enteritis that causes chronic changes in the intestinal epithelium, including flattening of the villi and loss of microvilli, with reduced absorption of xylose, fat, and nitrogen, and sometimes vitamin B12.26 With prolonged intestinal infections, bacterial overgrowth in the small intestine contributes further to malabsorption. 27 toms.34 Figure 9 shows the metabolic response of an individual with completely asymptomatic Q fever, whose cumulative nitrogen balance nevertheless became increasingly negative over a period of 21 days before daily balances became positive once again.3~ In INCAP metabolic studies in children, infections, with the exception of uncomplicated upper respiratory infections, were always associated with a period of negative nitrogen balance.…”

Section: Malabsorptionmentioning

confidence: 99%

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Rhoads lecture. Effect of Infection on Nutrient Requirements

Scrimshaw

1991

J Parenter Enteral Nutr

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All infections, no matter how mild, decrease nutrient intakes and increase nutrient losses even when subclinical. The losses include decreased intestinal absorption, direct loss of nutrients in the gut, internal diversion for metabolic responses to infection and increased basal metabolic rate when fever is present. In this way, infection influences not only protein and energy status but also that of most other nutrients. The clinical importance of these consequences of infection depends on the prior state of the individual, the nature and duration of the infection, and the diet of the individual during the infection, particularly dietary intake during the convalescent period and whether full recovery takes place before another infection occurs. In industrialized countries particular attention must be paid to the nutrition of hospitalized patients inasmuch as they are frequently debilitated by their primary disease, morbidity, and nutritional status. Morbidity and mortality are increased by nosocomial infections to which the poorly nourished individual is more susceptible.

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Section: Malabsorptionmentioning

confidence: 99%

“…October[25][26][27] 1989 at FLORIDA INTERNATIONAL UNIV on June 26, 2015 pen.sagepub.com Downloaded from…”

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Rhoads lecture. Effect of Infection on Nutrient Requirements

Scrimshaw

1991

J Parenter Enteral Nutr

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“…4,5 Entre los sobrevivientes, los episodios de diarrea pueden causar, precipitar o exacerbar la desnutrición, tanto de macro como de micronutrientes. 6 Los efectos deletéreos de la diarrea sobre el estado nutricio del niño se producen por uno o más de los siguientes mecanismos: reducción en la ingestión dietética, [7][8][9][10] absorción disminuida de nutrientes, [11][12][13] aumento del catabolismo, 14 pérdida directa de nutrientes por el intestino 8,15,16 e ineficiencia metabó-lica debida a deficiencias de micronutrientes. [17][18][19] En diversos estudios se ha demostrado que, entre las ventajas de la alimentación sostenida durante la diarrea, están la recuperación más rápida de la fisiología alterada, incluyendo la absorción intestinal; 20,21 asimismo, los episodios diarreicos se hacen más cortos [22][23][24] y hay mayor ganancia de peso de los niños durante y después del episodio diarreico.…”

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Alimentación sostenida durante diarrea aguda en niños menores de cinco años

1998

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ARTÍCULO ORIGINAL Alimentación durante diarrea agudaMartínez-Salgado H, Diez-Urdanivia S, Meneses-Díaz LM. Sustained feeding during acute diarrhea in children younger than five years of age. Salud Publica Mex 1998;40:141-149. AbstractObjective. To identify locally available and culturally acceptable foods for children with acute diarrhea, and test their acceptance and effect on the child's weight. Material and methods. 142 mothers of children younger than five years of age living in rural communities were interviewed to indentify culturally accepted diets by means of group sorting. These were displayed in a multidimensional scale. A descriptive study was performed of the clinical course of 54 children, ages 4 to 50 months who received the designed diets during the first 48 hours of diarrhea. Results. The designed diets considered age of the child, and stage of the disease. Children spent 47.6 ± 22.2 h in the hospital during which they consumed 44.8 ± 28.6 kcal/kg/day (additional to breast milk) and they gained 70.6 ± 179.7 g. A direct relationship was observed between increasing age and larger caloric intake, and between this and greater weight gain. Conclusion. Children showed good acceptance of diets. Caloric intake was enough to prevent weight loss.

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“…Investigators have also shown that during an acute enteric illness, early nutritional intervention of nourished infants is well tolerated. A rapid return to adequate nutritional intake results in reduced weight loss but does not alter the duration or severity of the diarrheal illness (4)(5)(6)(7)(8)(9)(10)(11)(12)(13). Early refeeding also may prevent fatal hypoglycemia, a recently recognized complication of acute diarrheal illness in infants (14).…”

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confidence: 99%

“…We established a model of protein-energy malnutrition in suckling infant rabbits and used it to demonstrate that nutrient deprivation reduces small intestinal mass, impairs mucosal growth, delays maturation and enhances ileal glucose-stimulated Na+ transport (1 [6][7][8][9][10][11][12][13][14][15][16][17][18]. Subsequent research demonstrated that the intestinal injury suffered by the malnourished infant infected with an enteric pathogen is more severe and more prolonged compared to that sustained by infected dietary controls (17).…”

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Refeeding Enhances Intestinal Repair during an Acute Enteritis in Infant Rabbits Subjected to Protein-Energy Malnutrition

Butzner

Gall

1991

Pediatr Res

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ABSTRACT. We examined the effects of refeeding during an acute bacterial enteritis on small intestinal repair in infant rabbits subjected to protein-energy malnutrition and in noninfected and infected dietary controls. Malnutrition was induced by litter expansion at 7 d of age. Randomly selected litters from both dietary groups were infected on d 17 with Yersinia enterocolotica. Inflammation and intestinal damage were observed in the jejunum and ileum at the "acute stage" of infection in 23-d-old animals from both dietary groups, as evidenced by an inflammatory infiltrate, blunted villi, and reduced disaccharidase activities. In addition, ileal glucose-stimulated Na+ absorption was depressed. On d 24, a 7-d period of ad libitum refeeding of breast milk and rabbit feed was initiated in randomly selected litters of infected-malnourished animals and all dietary controls. Mucosal repair was nearly complete at 31 d of age in infected dietary controls and in the infectedmalnourished animals that were refed, as demonstrated by the recovery of segmental mucosal mass and ileal glucosestimulated Na+ transport in association with the resolution of inflammation and diarrhea. Only mucosal disaccharidase activities remain depressed. In contrast, in 31-d-old infected-malnourished animals subjected to ongoing nutrient deprivation, severe intestinal damage persisted as evidenced by increased mortality, ongoing intestinal inflammation, mucosal hypoplasia, depressed disaccharidase activities, and reduced glucose-stimulated Na+ transport. We conclude that a refeeding regimen introduced during an acute bacterial enteritis is well tolerated and promotes recovery of intestinal mass, structure, and function in malnourished infant rabbits and dietary controls.

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Intake and absorption of nutrients in children with cholera and rotavirus infection during acute diarrhea and after recovery

Cited by 36 publications

References 13 publications

Rhoads lecture. Effect of Infection on Nutrient Requirements

Rhoads lecture. Effect of Infection on Nutrient Requirements

Alimentación sostenida durante diarrea aguda en niños menores de cinco años

Refeeding Enhances Intestinal Repair during an Acute Enteritis in Infant Rabbits Subjected to Protein-Energy Malnutrition

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