2014
DOI: 10.1007/s11357-014-9709-1
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: Long-living Ames dwarf mice (df/df) characterized by growth hormone (GH) deficiency are widely used in aging research because of their 40-60 % lifespan extension compared to normal (N) littermates. Importantly, these mice not only live longer but are also protected from age-related diseases including insulin resistance. Several studies demonstrate that df/df mice have enhanced insulin signaling in different insulin-sensitive tissues and suggest that this is a mechanism for extended lifespan. However, it is unk… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

4
14
0

Year Published

2014
2014
2020
2020

Publication Types

Select...
6
2

Relationship

0
8

Authors

Journals

citations
Cited by 26 publications
(18 citation statements)
references
References 46 publications
4
14
0
Order By: Relevance
“…Genes involved in insulin signaling and oxidative stress have been implicated as evolutionarily conserved mechanisms affecting life span in Mus musculus (53,54), Drosophila (55-57), Caenorhabditis elegans (58, 59), and yeast (60,61). Consistent with the lack of phenotypic correlation between phototaxis senescence and life span, we did not find genes associated with these mechanisms in our association analyses.…”
Section: Discussionsupporting
confidence: 66%
“…Genes involved in insulin signaling and oxidative stress have been implicated as evolutionarily conserved mechanisms affecting life span in Mus musculus (53,54), Drosophila (55-57), Caenorhabditis elegans (58, 59), and yeast (60,61). Consistent with the lack of phenotypic correlation between phototaxis senescence and life span, we did not find genes associated with these mechanisms in our association analyses.…”
Section: Discussionsupporting
confidence: 66%
“…Early studies on decreased capillary density in the peripheral circulation of hypertensive experimental animals and human patients proposed that rarefaction can be either structural (capillary attrition) or functional, associated with impaired recruitment of nonperfused capillaries (Chen et al 1981;Hashimoto et al 1987;Ono et al 1989;Prewitt et al 1986;Prewitt et al 1982;Prewitt et al 1984;Stacy and Prewitt 1989;Sullivan et al 1983). Our studies provide additional evidence that interaction of IGF-1 deficiency and hypertension promote structural rarefaction in the mouse brain, extending previous findings obtained in hypertensive patients (Wolf et al 1994;Bell and Ball 1981;Bell and Ball 1990;Abernethy et al 1993;Mann et al 1986) and animal models of aging (Sonntag et al 1997;Wiesenborn et al 2014), hypertension (Toth et al 2013a) and IGF-1 deficiency (Lopez-Lopez et al 2004), but further studies are needed to understand their synergistic effects on the cerebral microvasculature.…”
Section: Discussionsupporting
confidence: 83%
“…To understand the effects of IGF-1 deficiency on the cerebral microcirculation in the present study, we used a novel mouse model of adult-onset isolated endocrine IGF-1 deficiency, which phenotypically better mimics age-related IGF-1 deficiency observed in humans that most other available rodent models of GH/IGF-1 deficiency (Arum et al 2014a;Hill et al 2015;Rojanathammanee et al 2014;Wiesenborn et al 2014;Arum et al 2014b;Schneider et al 2014). Serum IGF-1 levels and physiological parameters obtained in the same experimental cohorts of animals used for the present study have been recently reported (Toth et al 2014a).…”
Section: Resultsmentioning
confidence: 99%
“…However, clamps have been performed in other mouse models where GH output or signaling is altered. Specifically, a very recent paper performed clamps in Ames mice (34). In that study, insulin actions are improved in muscle, fat, and liver.…”
Section: Discussionmentioning
confidence: 99%