Insulin Sensitivity, Depression/Anxiety, and Physical Fitness in At-Risk Adolescents

Bruggink, Stephanie; Shomaker, Lauren B.; Kelly, Nichole R.; Drinkard, Bart; Chen, Kong Y.; Brychta, Robert J.; Cassidy, Omni; Demidowich, Andrew P.; Brady, Sheila M.; Tanofsky‐Kraff, Marian; Yanovski, Jack A.

doi:10.1055/a-0889-8653

Cited by 4 publications

(7 citation statements)

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“…Although little research has been done on the relationship between anxiety and metabolic risk factors in adolescents, however, a recent study has found a significant association between anxiety and some metabolic risk factors in this population group ( 18 ). Similarly, another study conducted in adolescents reported a relationship between anxiety symptoms and insulin resistance ( 19 ), which may lead to worsening metabolic outcomes in at-risk youth. Furthermore, studies have shown that anxiety symptoms are associated with an increased risk of cardiovascular disease and other metabolic problems in young adults ( 16 , 17 ).…”

Section: Discussionmentioning

confidence: 98%

“…In particular, it is possible that people with anxiety are more likely to have a sedentary lifestyle, increasing the risk of obesity and cardiovascular disease ( 61 ). Furthermore, anxiety symptoms can increase the release of stress hormones, such as cortisol, which can promote abdominal fat gain and insulin resistance ( 19 , 62 ).…”

Section: Discussionmentioning

confidence: 99%

“…Although there is less research examining these connections in adolescents, a study recently found a statistically significant relationship between anxiety and some metabolic risk factors in this population ( 18 ). Another study conducted in adolescents reported a relationship between anxiety symptoms and insulin resistance ( 19 ), which may lead to worsening metabolic outcomes in at-risk youth.…”

Section: Introductionmentioning

confidence: 99%

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Associations between social network addiction, anxiety symptoms, and risk of metabolic syndrome in Peruvian adolescents—a cross-sectional study

Saintila,

Oblitas-Guerrero,

Larrain-Tavara

et al. 2024

Front. Public Health

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BackgroundThe link between physical and mental health and screen time in adolescents has been the subject of scientific scrutiny in recent years. However, there are few studies that have evaluated the association between social network addiction (SNA) and metabolic risk in this population.ObjectiveThis study determined the association between SNA and anxiety symptoms with the risk of metabolic syndrome (MetS) in adolescents.MethodsA cross-sectional study was conducted in Peruvian adolescents aged 12 to 18 years, who completed a Social Network Addiction Questionnaire and the Generalized Anxiety Disorder 2-item scale (GAD-2), between September and November 2022. A total of 903 participants were included in the study using a non-probability convenience sample. Sociodemographic and anthropometric data were also collected. Binary logistic regression was used to explore the association between SNA and anxiety symptoms with MetS in a cross-sectional analysis.ResultsMales were more likely to have MetS than females (OR = 1.133, p = 0.028). Participants who were 16 years of age or older and those with excess body weight were 2.166, p = 0.013 and 19.414, p < 0.001 times more likely to have MetS, respectively. Additionally, SNA (OR = 1.517, p = 0.016) and the presence of anxiety symptoms (OR = 2.596, p < 0.001) were associated with MetS.ConclusionOur findings suggest associations between SNA, anxiety symptoms, and MetS among youth. However, more studies are needed to better understand this association and to deepen the possible clinical and public health implications.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Associations between social network addiction, anxiety symptoms, and risk of metabolic syndrome in Peruvian adolescents—a cross-sectional study

Saintila,

Oblitas-Guerrero,

Larrain-Tavara

et al. 2024

Front. Public Health

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“…In addition to the direct effect of insulin on the nervous system, in recent years, some findings suggested that the association was related to the reduction of insulin receptor or the activity of receptor (ie, insulin resistance) in brain, 26‐28 and the insulin resistance was positively associated with depression 5 . Long‐term feeding of high‐fat diet induces peripheral insulin resistance.…”

Section: Insulin and Depressionmentioning

confidence: 99%

Potential role of insulin on the pathogenesis of depression

et al. 2020

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| INTRODUC TI ONDiabetes is a metabolic disease characterized by hyperglycaemia due to the defect of insulin secretion or impaired insulin biological effect. A survey has shown that about 30% of people with diabetes also suffer from depression and 10% have severe depression, which suggests a close relationship between the two diseases. 1,2 The mechanism of depression as a complication of diabetes is not completely clear, but studies have found that insulin deficiency or insulin resistance is the symptom that can also be observed in major depression disorder. [3][4][5] Insulin is the only hormone in the human body that reduces the blood glucose level and promotes the synthesis of glycogen, fat and protein. Several studies found that insulin had the ability to affect the nervous system. 6-8 Insulin receptors were distributed in other parts of the brain, except for the parts related to food intake and energy. 9-11 Experiments have gradually revealed other functions of insulin in the brain, for instance promoting memory, protecting neurons, regulating synaptic plasticity and maintaining HPA axis homeostasis. [12][13][14] These effects of insulin may provide a background for its relationship with depression. 15,16 In this case, although there is no direct evidence supporting the link between insulin and treatment for depression, more and more researches support this hypothesis. Here, we review the relationship between insulin signalling and neurophysiological homeostasis, neurotrophic metabolism, cellular pathways and some survey statistics.The exploration of these links and the validation of more relevant mechanisms will develop a new impact on the way of the diagnosis and treatment of depression. | IN SULIN AND DEPRE SS I ONAs early as 1980s, many evidences proved that insulin influenced depression and functional insulin receptors were widely present in the brain. [17][18][19] Data from clinical and epidemiological studies demonstrate a two-way link between emotion and metabolic dysfunction. In young depression patients, insulin sensitivity is significantly decreased. 20,21 Compared with "low insulin" (1.5 mU/kg × min), "high insulin" (15 mU/kg × min) induces a more pronounced of the ability to remember word lists in human being. 22 Intranasal delivery of insulin in awake mice can transmit regulatory and metabolic AbstractThe regulation of insulin on depression and depression-like behaviour has been widely reported. Insulin and activation of its receptor can promote learning and memory, affect the hypothalamic-pituitary-adrenal axis (HPA) balance, regulate the secretion of neurotrophic factors and neurotransmitters, interact with gastrointestinal microbiome, exert neuroprotective effects and have an impact on depression. However, the role of insulin on depression remains largely unclear. Therefore, in this review, we summarized the potential role of insulin on depression. It may provide new insight for clarifying role of insulin on the pathogenesis of depression.

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“…En China, Ren et al, (2019) analizaron la relación ajustada entre el tercil de fuerza relativa de agarre y la puntuación total de los síntomas depresivos en jóvenes universitarios, encontrando que la fuerza prensil, se relaciona de manera significativa e independiente, con menor riesgo de sufrir síntomas depresivos. Bruggink et al, (2019) encontraron que en 241 jóvenes entre los 12 y 17 años con obesidad, los síntomas depresivos estaban relacionados con menor distancia recorrida en una prueba de capacidad cardiorrespiratoria. Los estudios anteriores evidencian que mejoras en los componentes de la condición física (fuerza y resistencia cardiorrespiratoria) pueden conducir a un menor riesgo de síntomas depresivos en jóvenes (Jerstad et al, 2010).…”

Section: Introductionunclassified

Variables de condición física predictivas de sintomatología depresiva en estudiantes universitarios de Cali, Colombia

Carrillo Arango,

Atencio-Osorio,

Vidarte Claros

2023

Psicogente

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Objetivo: Determinar las variables de condición física saludable predictoras de sintomatología depresiva en jóvenes universitarios. Método: Este estudio presenta un diseño observacional descriptivo de corte transversal con una fase multivariada, que utilizó el cuestionario autoadministrado BECK (BDI-2) con el objetivo de determinar sintomatología depresiva, en una muestra de 344 estudiantes universitarios entre 18 y 39 años, matriculados en cuatro diferentes universidades de la ciudad de Santiago de Cali, Colombia. La condición física relacionada con la salud se valoró a partir de la batería Alpha Fit Adultos; con los análisis correlacionales se construyó un modelo de regresión logística binario que pudiera establecer cuáles variables de condición física se asocian a una sintomatología depresiva en este tipo de población. Resultados: Correlaciones inversas y estadísticamente significativas fueron observadas entre el puntaje de depresión del inventario de Depresión de Beck-II, con los indicadores de condición física aeróbica r = -0,202, p=0,000; fuerza prensil media r = -0,113, p=0,036; salto alto r = -0,177, p=0,000; flexión de brazos r = -0,158, p=0,003; y test de figura en 8 r = -0,146, p=0,006). Universitarios con mayores niveles de sintomatología depresiva presentan un fenotipo de menor condición física, principalmente en el indicador de resistencia cardiorrespiratoria (β= -0,059; p<0,004 Exp (B) 0,942). Conclusiones: Los resultados obtenidos en el presente estudio muestran que un fenotipo asociado a menor condición física cardiorrespiratoria se asocia con mayores niveles de sintomatología depresiva.

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Insulin Sensitivity, Depression/Anxiety, and Physical Fitness in At-Risk Adolescents

Cited by 4 publications

References 34 publications

Associations between social network addiction, anxiety symptoms, and risk of metabolic syndrome in Peruvian adolescents—a cross-sectional study

Associations between social network addiction, anxiety symptoms, and risk of metabolic syndrome in Peruvian adolescents—a cross-sectional study

Potential role of insulin on the pathogenesis of depression

Variables de condición física predictivas de sintomatología depresiva en estudiantes universitarios de Cali, Colombia

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