Insulin resistance index (HOMA-IR) in the differentiation of patients with non-alcoholic fatty liver disease and healthy individuals

Salgado, Ana Lúcia Farias de Azevedo; Carvalho, Leonardo César; Oliveira, Ana Cláudia de; Santos, Virgínia Nascimento dos; Vieira, José Gilberto H.; Parise, Edison Roberto

doi:10.1590/s0004-28032010000200009

Cited by 200 publications

(124 citation statements)

References 28 publications

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“…In the present study, the mean values of HOMA-IR in both groups were greater than those of healthy adults (36). Similar to our study that showed GCBE significantly reduced FBS and HOMA-IR index, Sarria et al in a randomized, controlled, crossover trial on 52 healthy subjects, who consumed three servings/day of the green/roasted (35:65) coffee blend for eight weeks, showed that HOMA-IR and FBS significantly reduced (21).…”

Section: Discussionsupporting

confidence: 90%

Effects of Green Coffee Bean Extract Supplementation on Patients with Non-Alcoholic Fatty Liver Disease: A Randomized Clinical Trial

et al. 2017

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Background: Non-alcoholic fatty liver disease (NAFLD) is a major worldwide public health problem with no effective treatment options. Green coffee bean extract (GCBE) is a rich source of bioactive phytochemicals with a variety of biochemical and physiological effects. Objectives: The aim of this study was to investigate the effects of GCBE on the management of patients with NAFLD. Methods: 44 patients with NAFLD were enrolled in a parallel, double-blind, placebo-controlled clinical trial. The participants were administered either GCBE or placebo (1 gram/day) for 8 weeks. They also were advised to follow a standard energy-balanced diet and physical activity. Liver ultrasonography, anthropometric variables, and biochemical parameters were compared at pre-and post-intervention.

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Section: Discussionsupporting

confidence: 90%

Effects of Green Coffee Bean Extract Supplementation on Patients with Non-Alcoholic Fatty Liver Disease: A Randomized Clinical Trial

et al. 2017

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“…17,18 Finally, we dichotomized HbA1c% using standardized cut points (< 6.5% as the referent versus ≥ 6.5%). Each of the outcome variables was assessed at baseline, 6 months, and 12 months post-intervention.…”

Section: Discussionmentioning

confidence: 99%

The Impact of Sleep Debt on Excess Adiposity and Insulin Sensitivity in Patients with Early Type 2 Diabetes Mellitus

Arora

Chen

Cooper

et al. 2016

Journal of Clinical Sleep Medicine

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Study Objectives:We examined cross-sectional and prospective associations between sleep debt and adiposity measures, as well as homeostatic model assessment-insulin resistance (HOMA-IR) in early type 2 diabetes. Methods: Prospective data analysis from participants of a randomized controlled trial based on an intensive lifestyle intervention (usual care, diet, or diet and physical activity). Data were collected at baseline, 6 months, and 12 months post-intervention. The study was performed across five secondary care centers in the United Kingdom. Patients (n = 593) with a recent diagnosis of type 2 diabetes were recruited. Objective height and weight were ascertained for obesity status (body mass index [BMI]; ≥ 30 kg/m 2 ), waist circumference (cm) for central adiposity, and fasting blood samples drawn to examine insulin resistance (IR). Seven-day sleep diaries were used to calculate weekday sleep debt at baseline, calculated as average weekend sleep duration minus average weekday sleep duration. Results: At baseline, compared to those without weekday sleep debt, those with weekday sleep debt were 72% more likely to be obese (OR = 1.72 [95% CI:1.03-2.88]). At six months, weekday sleep debt was significantly associated with obesity and IR after adjustment, OR = 1.90 (95% CI:1.10-3.30), OR = 2.07 (95% CI:1.02-4.22), respectively. A further increase at 12 months was observed for sleep debt with obesity and IR: OR = 2.10 (95% CI:1.14-3.87), OR = 3.16 (95% CI:1.38-7.24), respectively. For every 30 minutes of weekday sleep debt, the risk of obesity and IR at 12 months increased by 18% and 41%, respectively. Conclusions: Sleep debt resulted in long-term metabolic disruption, which may promote the progression of type 2 diabetes in newly diagnosed patients. Sleep hygiene/education could be an important factor for future interventions to target early diabetes. Keywords: insulin resistance, type 2 diabetes mellitus, sleep debt, obesity, body mass index, waist circumference, central adiposity Citation: Arora T, Chen MZ, Cooper AR, Andrews RC, Taheri S. The impact of sleep debt on excess adiposity and insulin sensitivity in patients with early type 2 diabetes mellitus. J Clin Sleep Med 2016;12(5):673-680. I NTRO DUCTI O NThe International Diabetes Federation recently estimated that, globally, over 382 million individuals had diabetes in 2013 (an estimated 46.3% undiagnosed) and that this number is expected to rise to 592 million by 2035.1 The majority of affected individuals (over 90%) have type 2 diabetes, which is closely related to excess adiposity and its associated lifestyle factors such as poor diet and low physical activity. Sleep (duration and quality) may be another important factor associated with both obesity and type 2 diabetes, as suggested by both population and experimental studies.2-6 It has been hypothesized that social and work demands increasingly result in shorter sleep duration than required physiologically. 7 This sleep loss, accumulated into a sleep debt during weekdays, may be partially repaid by extra...

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“…Other important considerations while calculating HOMA-IR is that it should not be solely relied upon in patients who have already been on insulin treatment, poor glycemic control and near total dysfunction of b cells. Some studies have also suggested that HOMA-IR values are increased in non-alcoholic fatty liver disease (12) . Hence in these patients also raised HOMA-IR values should be cautiously interpreted.…”

Section: Discussionmentioning

confidence: 99%

Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) in the Diagnosis of Insulin Resistance and Prediabetes

Bhosle¹,

Sayyed²,

Bhagat³

et al. 2016

jmscr

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Insulin resistance index (HOMA-IR) in the differentiation of patients with non-alcoholic fatty liver disease and healthy individuals

Abstract: HOMA-IR values above or equal to 2.0 or 2.5 show enhanced diagnostic value in distinguishing non-alcoholic fatty liver disease carriers from control group individuals.

Cited by 200 publications

References 28 publications

Effects of Green Coffee Bean Extract Supplementation on Patients with Non-Alcoholic Fatty Liver Disease: A Randomized Clinical Trial

Effects of Green Coffee Bean Extract Supplementation on Patients with Non-Alcoholic Fatty Liver Disease: A Randomized Clinical Trial

The Impact of Sleep Debt on Excess Adiposity and Insulin Sensitivity in Patients with Early Type 2 Diabetes Mellitus

Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) in the Diagnosis of Insulin Resistance and Prediabetes

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