Insulin resistance, growth factors and cytokine levels in overweight women with breast cancer before and after chemotherapy

Abstract

Post-glucose load insulin values significantly decrease after chemotherapy. There is a positive relationship between BMI and post-glucose load insulin before and after chemotherapy. The contribution of the reduction in insulin, a known growth factor, to the outcome of chemotherapy in these patients remains speculative at present.

Serum levels of angiogenic cytokines decrease after radiotherapy in non-Hodgkin lymphomas

“…Others have found that in patients with head and neck tumours, FGF-2 and VEGF decrease after radiotherapy, which has an impact on response and progression-free survival [11,12]. VEGF also declined in patients undergoing chemotherapy for advanced breast cancer, in whom the better the response, the greater the drop recorded [13]. Similar results were observed in patients receiving highdose chemotherapy for acute myeloid leukaemia, in whom serum levels of angiogenin and FGF-2 decreased with response [14].…”

Glucose metabolism disorders in cancer patients in a Chinese population

“…In other words, cancer patients demand more glucose but do not make good use of it, reflecting hypoglycemia [60,61] or hyperglycemia [23,25,33,34], and inducing malnutrition which can lead to death. Moreover, after chemotherapy, glycemia levels may increase [23,25] with a corresponding reduction in insulin [26]. Furthermore, ectopic hormone [27,28], such as adrenal corticosteroid also can elevate plasma glucose.…”

“…Meanwhile, there are several plausible explanations for the mechanisms by which GMDs develop in cancer patients, including drugs for chemotherapy [23][24][25][26], ectopic hormone [27,28], and destruction of cancer cells or cytokine [28]. However, the prevalent characteristics of GMDs in cancer patients are still unclear, and the disparities of GMDs among different types of cancers are also unknown.…”

“…Whereas, it seems that most attention has been focused on the increased risks of malignancy among patients with GMDs [7,8,12] hitherto, but the reverse also applies and cancer patients may also face with the threat of GMDs [23,26,33,34]. Moreover, the focus in many reports was merely on the relationship between a single malignant neoplasm and hyperglycemia [6,9,10,[35][36][37][38][39][40], rather than a range of cancer.…”

Oxidative stress and hematological profiles of advanced breast cancer patients subjected to paclitaxel or doxorubicin chemotherapy

“…Few studies have investigated the parameters of redox and metabolic changes in patients with breast cancer after chemotherapy infusion [15,16] and no differential evaluations regarding cancer disease or treatment-derived alterations have been considered. The scientific literature is controversial regarding the oxidative parameters of patients with breast cancer, who are undergoing chemotherapy.…”