Insulin resistance, dyslipidemia, and metabolic syndrome in women with polycystic ovary syndrome

El-Mazny, Akmal; Abou-Salem, Nermeen; El-Sherbiny, Walid; El-Mazny, Ahmed

doi:10.1016/j.ijgo.2010.01.014

Cited by 49 publications

(37 citation statements)

References 21 publications

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“…It is a common endocrinopathy in women, affecting approximately 5-10% of the reproductively mature women [1,2,3]. This complex reproductive metabolic disorder is associated with insulin resistance, hyperandrogenism, obesity and weight-related disorders [4,5]. …”

Section: Introductionmentioning

confidence: 99%

Predictors of Gestational Diabetes Mellitus in Chinese Women with Polycystic Ovary Syndrome: A Cross-Sectional Study

Zhang

Jin²,

Qin

et al. 2015

Gynecol Obstet Invest

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Aims: This study aims to explore the independent predictors of gestational diabetes mellitus (GDM) in Chinese women with polycystic ovary syndrome (PCOS). Methods: This cross-sectional study analyzed primigravid women with PCOS and classified them as those with and without GDM. Independent risk factors and model performance were analyzed using multivariate logistic regression and the area under the curve (AUC) of receiver operating characteristic (ROC), respectively. Results: Maternal body mass index, waist circumference, waist-to-hip ratio (WHR), fasting glucose, insulin, sex hormone-binding globulin (SHBG), homeostasis model assessment-insulin resistance (HOMA-IR) before pregnancy, gestation weight gain before 24 weeks and the incidence of family history of diabetes were different in the 2 groups. Logistic regression analysis showed that pre-pregnancy WHR, SHBG, HOMA-IR and gestation weight gain before 24 weeks were the independent predictors of GDM. ROC curve analysis confirmed that gestation weight gain before 24 weeks (AUC 0.767, 95% CI 0.688-0.841), pre-pregnant WHR (AUC 0.725, 95% CI 0.649-0.802), HOMA-IR (AUC 0.711, 95% CI 0.632-0.790) and SHBG levels (AUC 0.709, 95% CI 0.625-0.793) were the strong risk factors. Conclusions: In Chinese women with PCOS, factors of gestation weight gain before 24 weeks, pre-pregnant WHR, HOMA-IR and SHBG levels are strongly associated with subsequent development of GDM.

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Section: Introductionmentioning

confidence: 99%

Predictors of Gestational Diabetes Mellitus in Chinese Women with Polycystic Ovary Syndrome: A Cross-Sectional Study

Zhang

Jin²,

Qin

et al. 2015

Gynecol Obstet Invest

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“…Bu grup hastalarda dislipidemi, anormal glukoz metabolizması ve hipertansiyon prevelansı artmıştır [13]. PKOS hastalarının aile hikayesi ile ilgili literatürde çalışmalar bulunmaktadır.…”

Section: Discussionunclassified

Evaluation of lipid parameters and family history of diabetes mellitus in polycystic ovary syndrome

Gözükara¹

2013

Diclemedj

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ÖZETAmaç: Bu çalışmada polikistik over sendromu (PKOS) tanısı alan hastalarda lipid parametreleri ile hastaların aile ve akrabalarında Diabetes Mellitus (DM) sıklığı araştırıl-mıştır.Yöntemler: Kesitsel yapılan bu çalışmada Erzurum Böl-ge Eğitim ve Araştırma Hastanesinde PKOS tanısı almış 120 hasta ve 30 sağlıklı kontrol grubu çalışmaya dahil edilmiştir. Hastaların vücut kitle indeksleri, soy geçmişle-ri, ultrasonografik bulguları, kan hormon profilleri (Folikül stimulan hormon (FSH), Luteinizan hormon (LH), total ve serbest testesteron, prolaktin (PRL), Tiroid stimulan hormon (TSH)), lipid parametreleri (düşük dansiteli lipoprotein (LDL), yüksek dansiteli lipoprotein (HDL), trigliserid), plazma insülin seviyeleri, açlık kan glukoz değeri ve HO-MA-IR (Homeostatic model assessment -insulin resistance) kaydedildi. Hastaların ailesinde ve akrabalarında DM olup olmadığı sorgulandı. Bulgular:Ailede DM hikayesi PKOS'lu hastaların 29 (%24)' unda, kontrol grubu hastalarının 2 (%6)' sinde saptanmıştır. Uzak akrabalarda DM hikayesi PKOS'lu grupta 45 (%35) hastada, kontrol grubunda ise 5 (%17) hastada saptandı. HOMA-IR değerleri, açlık kan şekeri ve insü-lin seviyeleri PKOS grubunda istatistiksel olarak anlamlı yüksek bulundu (p<0,05). Lipid parametreleri açısından gruplar arasında istatistiksel olarak anlamlı fark bulunmadı (p>0,05).Sonuç: PKOS lu hastaların aile ve akrabalarında DM sıklığının kontrol grubuna göre istatistiksel olarak anlamlı şekilde daha fazla olduğu saptandı. Önceki çalışmaların aksine olarak bu çalışmada polikistik over sendromunda lipid parametrelerinde bozulma saptanmadı.Anahtar kelimeler: PKOS, aile hikayesi, DM, lipid parametreleri ABSTRACT Objective: In the present study we investigated lipid parameters of Polycystic Ovary Syndrome (PCOS) patients and Diabetes Mellitus (DM) history of their family and relatives. Methods:In this cross-sectional study, one hundred and twenty patients with PCOS and 30 healthy controls were involved at Erzurum Research and Training Hospital. History, Body mass index (BMI), ultrasonography findings, blood hormone profiles (Follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), thyroidstimulating hormone (TSH), total and free testosterone (Total-T and Free-T), prolactin (PRL)), and serum lipids (total cholesterol (Total-C), high-density cholesterol (HDL-C), low-density cholesterol (LDL-C), and triglycerides (TG), fasting blood glucose and plasma insulin level were measured. HOMA-IR (Homeostatic model assessmentinsulin resistance) was calculated.Results: DM history in the family was found in 29 (24%) of PCOS patients and 2 (6%) of healthy controls. The difference between groups was statistically significant (p<0.05). DM history in the relatives was determined in 45 (35%) PCOS patients and 5 (17%) controls. The difference between groups was statistically significant (p<0.05). HOMA-IR, fasting glucose and insulin levels were significantly higher in PCOS patients (p<0.05). Lipid parameters were not significantly different between the two groups. Concl...

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“…The mechanism for pregnancy-induced changes in lipids is not completely understood, but appears to be partly caused by elevated oestrogen, progesterone and human placental lactogen. 5,6 Lipid levels in women with Preterm labour or pre-eclampsia are reported to be higher than those in healthy pregnant women. [7][8][9] Lipid levels in early pregnancy can be a good predictor of development of pre-eclampsia in patients.…”

Section: Introductionmentioning

confidence: 95%

“…Dyslipidemia in early pregnancy leads to more oxidative stress by the formation of lipid peroxides and reactive oxygen species, thus predisposing to the development of preeclampsia. 10,11 The pathology of this multi system disorder should be considered as two staged process. 12 …”

Section: Introductionmentioning

confidence: 99%

Association of dyslipidemia in second trimester of pregnancy with preeclampsia

Kanmani¹,

Subramanian²

2018

Int J Reprod Contracept Obstet Gynecol

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INTRODUCTIONPre-eclampsia is a pregnancy-specific condition with a multifactorial etiology associated with proteinuria and hypertension.1,2 It is one of the common causes of maternal and perinatal morbidity and mortality.Berg and colleagues stated that around 50% of these preeclampsia related deaths are preventable. 3The exact etiology of preeclampsia is not known. But there are risk factors predisposing to development of preeclampsia. Genetic factors include family history of preeclampsia. 4 Obstetric factors include primiparity, previous history of pre-eclampsia, new paternity, multiple pregnancy, hydrops fetalis with large placenta, hydatidiform mole, triploidy. ABSTRACT Background:The study aimed to determine whether dyslipidemia in the second trimester of pregnancy is associated with pre-eclampsia and to investigate and compare the levels of serum lipids among preeclampsia and normal pregnant women. Methods: This prospective cohort study was done between March 2016 to February 2017. Fasting lipid profile was taken for about 200 selected antenatal women between 18-20 weeks of gestation. The patients who developed preeclampsia were grouped as preeclampsia group and the rest of the patients were grouped as normal group. The maternal characteristics compared between two groups were age, parity, BMI and socioeconomic class according to modified Kuppuswamy scale. Results: There is statistical significance among the two groups with respect to BMI and parity whereas no significance with age distribution. Mean total cholesterol in Preeclampsia was 240.24±46.63 mg/dl and normal pregnancy was 186.10±28.02 mg/dl. Mean HDL in preeclampsia was 47.49±4.40mg/dl and normal pregnancy was 52.11±8.918 mg/dl. Mean LDL in preeclampsia was 140.43±36.92 mg/ dl and normal pregnancy was 94.6±24.5 mg/dl. Mean VLDL in preeclampsia was 64.48±15.76mg/dl and in normal pregnancy was 33.54±9.38 mg/dl, Mean Triglycerides in preeclampsia was 291.95±82.33 mg/dl and normal pregnancy was 166.78±48.83 mg/dl. Total cholesterol, Low density lipoprotein, very low-density lipoprotein, triglycerides were increased in preeclampsia when compared to normal pregnancy, which is statistically significant. Conclusions: Detecting dyslipidemia before 20 weeks of gestation helps to recognise pregnancies at high risk for preeclampsia and to detect and treat the disease earlier for a better maternal and perinatal outcome.

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Insulin resistance, dyslipidemia, and metabolic syndrome in women with polycystic ovary syndrome

Abstract: Insulin resistance is associated with dyslipidemia and MBS in women with PCOS. Lifestyle modification and insulin-sensitizing agents should be part of the management plan.

Cited by 49 publications

References 21 publications

Predictors of Gestational Diabetes Mellitus in Chinese Women with Polycystic Ovary Syndrome: A Cross-Sectional Study

Predictors of Gestational Diabetes Mellitus in Chinese Women with Polycystic Ovary Syndrome: A Cross-Sectional Study

Evaluation of lipid parameters and family history of diabetes mellitus in polycystic ovary syndrome

Association of dyslipidemia in second trimester of pregnancy with preeclampsia

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