Insulin resistance and acute coronary syndrome

Acute hyperglycemia and insulin resistance in acute heart failure syndromes without previously known diabetes

“…In non-diabetic STEMI patients submitted to PCI, we report that insulin resistance, as assessed by HOMA-index, is quite common, and helps in the early risk stratification, since it represents an independent predictor for in-hospital mortality [15]. In patients with ACS, insulin resistance quantified by the HOMA index, seems to have a significant important prognostic role, both in primary and secondary prevention [16].…”

Diagnostic Value of Acute Phase Proteins in Periodontal, Psychosomatic and Cardiometabolic Diseases: Response to Treatment

“…Although the traditional markers, reduced HDL-c, elevated LDL-c, triglycerides and visceral adiposity are associated with insulin resistance, it may independently influence the progression of coronary atherosclerotic plaques in asymptomatic patients, via endothelial dysfunction. Insulin resistance seems to have a significant prognostic role and informative for preventive care in acute coronary syndrome (Caccamo et al 2010). These mechanisms could impact on periodontal disease progression and therapeutic targets.…”

PPAR-γ as a therapeutic target in cardiovascular disease: evidence and uncertainty

“…At 10 mg, average fasting blood glucose may provide important information in several respects. First, because approximately half of nondiabetic patients with acute coronary or cerebrovascular syndromes are insulin resistant ( 215,216 ), potential effi cacy of pioglitazone in such populations would have broad applicability. Second, because patients in IRIS are not diabetic at enrollment, the trial is less likely to be confounded by differential use of other diabetic medications in the two treatment arms than prior trials of TZDs in diabetic subjects.…”