Insulin protects against type 1 diabetes mellitus-induced aortopathy associated with the inhibition of biomarkers of vascular injury in rats

Bin-Jaliah, Ismaeel; Hewett, Peter W.; Al‐Hashem, Fahaid; Haidara, Mohamed A; Kader, Dina H Abdel; Morsy, Mohamed D

doi:10.1080/13813455.2019.1632900

Cited by 3 publications

(2 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our results are in accordance with those of previous results (Firoozrai et al 2007;Ramakrishna and Jailkhani 2007). It has been found that hyperglycaemia leads to the generation of various types of ROS, including hydroxyl radical, which attacks the unsaturated fatty acid chain, leading to lipid peroxidation and MDA formation (Giacco and Brownlee 2010;Bin-Jaliah et al 2021). However, the present study did not show any correlation between blood glucose and the oxidative stress biomarker, MDA, in untreated diabetic patients.…”

Section: Discussionsupporting

confidence: 93%

Evaluation the effects of insulin on oxidant/antioxidant status in type 1 diabetic patients

Almulathanon¹,

Mohammad²,

Allwash³

2021

PHAR

View full text Add to dashboard Cite

Earlier works have revealed increased generation of reactive oxygen species (ROS) and decreased antioxidant levels in type 1 diabetes mellitus (T1DM). The current study aimed to investigate the effect of mixed insulin therapy on oxidative stress and antioxidant status in patients with T1DM. This study involved 75 participants who were divided into three groups: 20 healthy subjects as a control, 25 newly diagnosed patients with T1DM (without treatment) and 30 patients with T1DM treated with insulin (regular and Human Neutral Protamine Hagedorn (NPH)) twice daily. Fasting serum glucose (FSG), serum concentrations of insulin, malondialdehyde (MDA), catalase (CAT), reduced glutathione (GSH), and vitamins (C and E) were measured in all participants. Compared with the healthy control, serum glucose and MDA concentrations were observed to be significantly higher, while significantly lower concentrations of CAT, GSH, and vitamins (C and E) were found in both the treated and untreated diabetic groups. Although insulin therapy caused a significant decrease in blood sugar with a marked elevation in the levels of insulin, CAT, GSH and vitamin E compared to the untreated patients, the changes in the levels of MDA and vitamin C between diabetic groups were not significant. Moreover, the level of insulin resistance was significantly increased in insulin-treated patients as compared to the control and untreated diabetic groups. In conclusion, twice daily treatment with regular and NPH insulin can ameliorate hyperglycemia and improve antioxidant levels in patients with T1DM. However, the insulin regimen used in this study did not reveal a beneficial effect on oxidative stress and insulin resistance. Hence, exogenous antioxidants (vitamins C and E) can be used in combination with insulin to control these parameters.

show abstract

Section: Discussionsupporting

confidence: 93%

Evaluation the effects of insulin on oxidant/antioxidant status in type 1 diabetic patients

Almulathanon¹,

Mohammad²,

Allwash³

2021

PHAR

View full text Add to dashboard Cite

show abstract

“…Impaired wound healing is a major complication of diabetes mellitus (DM) and despite the associated risks, treatment strategies for diabetic-related wounds are limited. Endothelial dysfunction is an indicator of diabetes-induced macrovascular complications ( 1 , 2 ). Vascular differentiation at injury sites affects the speed of wound healing, while the homing and angiogenic differentiation of endothelial progenitor cells (EPCs) are critical for successful wound healing ( 3 ).…”

Section: Introductionmentioning

confidence: 99%

hsa_circ_0058092 protects against hyperglycemia‑induced endothelial progenitor cell damage via miR‑217/FOXO3

Cheng

Zheng

et al. 2020

Int J Mol Med

View full text Add to dashboard Cite

Circular RNAs (circRNAs) regulate the expression of genes that are critical for various biological and pathological processes. Previous studies have reported that the expression of hsa_circ_0058092 is decreased in patients with diabetes mellitus (DM); however, the specific role of this circRNA in DM is unknown. In the present study, endothelial progenitor cells (EPCs) were isolated and a decreased hsa_circ_0058092 expression was found under conditions of hyperglycemia (HG). The overexpression of hsa_circ_0058092 protected the EPCs against HG-induced damage by preserving cell survival, proliferation, migration and angiogenic differentiation. The overexpression of hsa_circ_0058092 also decreased the HG-induced increase in NADPH-oxidase proteins and inflammatory cytokines. Further investigation revealed that the overexpression of hsa_circ_0058092 enhanced FOXO3 expression, which was mediated through the interaction with miR-217. Furthermore, the upregulation of miR-217 or the downregulation of FOXO3 abolished the protective effects of hsa_circ_0058092 against HG-induced EPC damage. On the whole, these data suggest that hsa_circ_0058092 acts via the miR-217/FOXO3 pathway to protect against EPCs HG-induced damage, and to preserve the migration and angiogenesis of EPCs.

show abstract

Suppression of type 2 diabetes mellitus-induced aortic ultrastructural alterations in rats by insulin: an association of vascular injury biomarkers

Alzamil

Dawood

Hewett

et al. 2020

Ultrastructural Pathology

View full text Add to dashboard Cite

Insulin protects against type 1 diabetes mellitus-induced aortopathy associated with the inhibition of biomarkers of vascular injury in rats

Abstract: Insulin protects against type 1 diabetes mellitus-induced aortopathy associated with the inhibition of biomarkers of vascular injury in rats', Archives of Physiology and Biochemistry.

Cited by 3 publications

References 28 publications

Evaluation the effects of insulin on oxidant/antioxidant status in type 1 diabetic patients

Evaluation the effects of insulin on oxidant/antioxidant status in type 1 diabetic patients

hsa_circ_0058092 protects against hyperglycemia‑induced endothelial progenitor cell damage via miR‑217/FOXO3

Suppression of type 2 diabetes mellitus-induced aortic ultrastructural alterations in rats by insulin: an association of vascular injury biomarkers

Contact Info

Product

Resources

About