J. Neurosci. Res. volume 86, issue 3, P702-711 2008 DOI: 10.1002/jnr.21519 View full text
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V. Sivakumar, Y. Zhang, E. A. Ling, W. S. Foulds, C. Kaur

Abstract: As the response of the adult retina to hypoxia is likely to differ from that already established in the neonatal animal, this study was undertaken to examine the expression patterns of insulin-like growth factor-I (IGF-I) and -II (IGF-II), angiopoietin-2 (Ang-2), and pigment epithelium-derived growth factor (PEDF) in normal and hypoxic retinas of adult rats. In the latter, the retinas were examined from 3 hr to 14 days after hypoxic exposure. The mRNA and protein expression of IGF-I, IGF-II, Ang-2, and PEDF in…

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