Insulin-like growth factor I correlates with MELD and returns to normal level after liver transplantation

Castro, Gustavo Rodrigues Alves; Coelho, Júlio Cézar Uili; Parolin, Mônica Beatriz; Matias, Jorge Eduardo Fouto; Freitas, Alexandre Coutinho Teixeira de

doi:10.12659/aot.883819

Cited by 21 publications

(27 citation statements)

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“…Growth hormone levels were decreased in all studies that assessed this hormone, and a parallel increase was observed in IGF‐1 . The decrease in GH ranged from 51.4 to 70.4% , whereas the increase in IGF‐1 ranged from 210 to 750% .…”

Section: Resultsmentioning

confidence: 92%

“…The analysis included ten prospective studies , five retrospective studies and six cross‐sectional studies . Healthy controls were used for comparison in five studies . A detailed quality rating obtained from the Newcastle‐Ottawa Scale is shown in Table S2.…”

Section: Resultsmentioning

confidence: 99%

“…Database searches identified 5028 articles, of which 668 were duplicates. After screening the titles and abstracts and completing a detailed evaluation of full-text articles, we identified 20 (10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29) studies that met our inclusion criteria. At this stage, one study was excluded because of the short follow-up duration of the hormone levels (7 days), as surgical stress, body fluid shifts and postoperative graft dysfunction might have impacted endocrine function and represented a source of bias in our analysis (30).…”

Section: Study Selectionmentioning

confidence: 99%

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Effects of liver transplantation on endocrine function: a systematic review

Gariani

Toso

Philippe

et al. 2016

Liver International

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Patients with chronic liver disease (CLD) often experience secondary endocrine dysfunction. Therefore, because the liver plays a major role in endocrine function, liver transplantation (LT) may also be beneficial for the restoration of hormonal regulation. This systematic review collects and interprets the available literature on the effect of LT on endocrine and sexual function in adult patients. A systematic review was conducted by searching Pubmed (including Medline) and EMBASE for studies published from database inception until November 2015. We collected all relevant studies that discussed changes in hormonal and sexual function after LT. Studies were included if they assessed the effect of LT on sexual function or one of the following components of the hormone/endocrine axis: the hypothalamus-pituitary-gonadal axis, growth hormone (GH), insulin-like growth factor-1 (IGF-1) or thyroid function. The results are reported according to the Meta-analysis Of Observational Studies in Epidemiology (MOOSE) guidelines. Twenty-one studies with a total of 1274 patients were included. The results collected from the included studies suggested that LT improves the hormonal perturbation associated with CLD by restoring physiological levels of circulating GH, IGF-1, testosterone, estradiol, prolactin, follicle-stimulating hormone (FSH) and luteinizing hormone (LH). Thyroid function was not affected by LT, and sexual function was partially improved after LT. This systematic review suggests that LT is associated with an improvement in endocrine and sexual function in patients with CLD. This information should encourage clinicians who treat CLD patients to identify endocrine disturbances in this population, inform their patients of the effects of LT and assess post-transplantation improvements. Keywords endocrine dysfunction -hormone -liver transplantationThe liver plays a key role in a myriad of metabolic processes, including regulation of the endocrine system, which consists of a fine-tuned network of cells, glands and organs that secrete hormones directly into the blood to control physiological and behavioural activities (1, 2). Liver dysfunction often results in endocrine perturbations through the abolition of the balanced crosstalk between the endocrine system and the hepatic microenvironment (1, 3). Patients with advanced liver failure experience various hormonal alterations, which Abbreviations

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Section: Resultsmentioning

confidence: 92%

Section: Resultsmentioning

confidence: 99%

Section: Study Selectionmentioning

confidence: 99%

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Effects of liver transplantation on endocrine function: a systematic review

Gariani

Toso

Philippe

et al. 2016

Liver International

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“…In healthy subjects, IGF-1 and IGFBP-3 are dependent on the secretion of GH; however, the liver produces reduced amounts of IGF-1 in patients with cirrhosis, which results in an increase in the GH level because of the loss of negative feedback. The IGF-1 and IGFBP-3 levels were shown to be low in cirrhosis patients, but to improve after liver transplantation (28). These observations suggest that the liver function is involved in the regulation of the IGF-1 and IGFBP-3 levels.…”

Section: Discussionmentioning

confidence: 99%

The Relationship between the Growth Hormone/Insulin-like Growth Factor System and the Histological Features of Nonalcoholic Fatty Liver Disease

et al. 2017

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Objective Growth hormone (GH) deficiency has recently been reported as a cause of nonalcoholic fatty liver disease (NAFLD), and GH supplementation has been shown to improve the histology of NAFLD. The aim of the present study was to clarify the relationship between the histological severity of NAFLD and production of the GH/insulin-like growth factor 1 (IGF-1) axis. Methods A total of 222 Japanese patients with liver biopsy-confirmed NAFLD and 55 patients with hepatitis C virus (HCV)-related chronic liver disease (CLD) were enrolled in the present study. The serum levels of GH, IGF-1, and IGF-binding protein 3 (IGFBP-3) were measured and their relationships with the histological severity of liver disease were assessed. To exclude age- and sex-related differences, the IGF-1 standard deviation score (IGF-1:SDS) was determined for each patient. Results With respect to the stage of fibrosis in patients with NAFLD, the serum GH levels were higher and the serum IGFBP-3 levels and IGF-1:SDSs were lower in patients with cirrhosis (grade F4 fibrosis) than in patients grade F1-F3 fibrosis; moreover, these differences were statistically significant (all p<0.01). The GH, IGF-1, and IGFBP-3 levels were not correlated with fibrosis in patients with HCV-related CLD. Furthermore, the GH levels were lower and the IGFBP-3 levels were significantly higher in patients with severe steatosis (S3) than in patients with mild to moderate steatosis (S1-S2) (p<0.05). Conclusion Increased GH levels and decreased IGF-1 and IGFBP-3 levels might contribute to the progression of NAFLD. The GH/IGF-1 axis may be important in the development of NAFLD, but not in patients with HCV-related CLD.

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“…In this perspective some attempts with replacement hormonal therapy have been made in liver cirrhosis showing encouraging results [12, 13]. Few studies are available on the GH-IGF-1 axis in adult patients undergoing liver transplantation (LT) [14–17]. All studies show the prompt return to normal of the GF-IGF-1 axis after transplant.…”

Section: Introductionmentioning

confidence: 99%

Relationship between GH/IGF-1 Axis, Graft Recovery, and Early Survival in Patients Undergoing Liver Transplantation

Salso

Tisone

Tariciotti

et al. 2014

BioMed Research International

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Background. High levels of IGF-1 have been reported in patients with initial poor function of the graft after liver transplantation (LT). Correlation with other clinical variables or early survival has not been extensively investigated. Aim. To evaluate the GH/IGF-1 profile as a function of liver recovery and patients' early survival after LT. Methods. 30 transplanted patients (23 survivors and 7 nonsurvivors), were retrospectively enrolled in the study. GH and IGF-1 serum levels were assessed at baseline, graft reperfusion, and 1, 7, 15, 30 , 90, and 360 days after LT. Individual biochemical variables were also recorded. Results. After grafting, IGF-1 in blood linearly correlated with cholesterol (r = 0.6, P = 0.001). IGF-1 levels from day 15 after surgery were statistically higher in survivors as compared to nonsurvivors. ROC curves analysis identified an IGF-1 cut-off >90 μg/L, from day 15 after surgery, as a good predictor of survival (sensitivity 86%, specificity 95%, and P < 0.001). Conclusions. After LT, GH levels correlate with the extent of cytolysis, while IGF-1 is an indicator of liver synthetic function recovery. IGF-1 levels >90 μg/L (day 15–30) seem to be an indicator of short-term survival.

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Insulin-like growth factor I correlates with MELD and returns to normal level after liver transplantation

Abstract: Low levels of IGF-I and IGFBP-3 observed in patients with advanced liver cirrhosis are corrected after OLT. IGF-I and IGFBP-3 correlate negatively with MELD.

Cited by 21 publications

References 0 publications

Effects of liver transplantation on endocrine function: a systematic review

Effects of liver transplantation on endocrine function: a systematic review

The Relationship between the Growth Hormone/Insulin-like Growth Factor System and the Histological Features of Nonalcoholic Fatty Liver Disease

Relationship between GH/IGF-1 Axis, Graft Recovery, and Early Survival in Patients Undergoing Liver Transplantation

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