2016
DOI: 10.1074/jbc.m115.677351
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Abstract: Diabetes is accompanied by dysregulation of glucose, lipid, and protein metabolism. In recent years, much effort has been spent on understanding how insulin regulates glucose and lipid metabolism, whereas the effect of insulin on protein metabolism has received less attention. In diabetes, hepatic production of serum albumin decreases, and it has been long established that insulin positively controls albumin gene expression. In this study, we used a genetic approach in mice to identify the mechanism by which i… Show more

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Cited by 28 publications
(25 citation statements)
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“…Moreover, in our study, insulin was significantly higher in the TRIB group compared to the CTRL group. Albumin is strongly related to insulin synthesis [50,51] and it is well known that insulin is associated with muscle protein synthesis [52,53]. Moreover, the data in our study were in the physiological range [49].…”
Section: Discussionsupporting
confidence: 56%
“…Moreover, in our study, insulin was significantly higher in the TRIB group compared to the CTRL group. Albumin is strongly related to insulin synthesis [50,51] and it is well known that insulin is associated with muscle protein synthesis [52,53]. Moreover, the data in our study were in the physiological range [49].…”
Section: Discussionsupporting
confidence: 56%
“…43 Insulin was also demonstrated to maintain albumin expression in mice. 44 The results thus demonstrated that the hepatic function of the HepaRG™ cells was retained when cultured for at least 10 days in PneumaCult-ALI™ medium.…”
Section: Selecting a Coculture Medium Suitable For The Lung And Livermentioning
confidence: 71%
“…The PI3K signaling pathway serves a dominant role in the regulation of β-cell function ( 12 ), which is orchestrated by an intricate network of mediators. AKT/PKB, acting as a downstream target of PI3K, regulates the proliferation of β-cells through modulation of its multiple downstream genes, which include Forkhead box protein O1 (FOXO1) ( 13 ), glycogen synthase kinase-3 (GSK3) ( 14 ) and mammalian target of rapamycin (mTOR) ( 8 ), among others.…”
Section: Insulin Signaling Pathwaysmentioning
confidence: 99%
“…Recently, studies have focused on the mechanism behind inulin-mediated fat and glucose metabolism, though few have investigated protein metabolism ( 13 ). For instance, it has been reported that hyperglycemia promoted compensatory β-cell proliferation to meet the insulin demand induced by hyperglycemia ( 27 ).…”
Section: Insulin Signaling Pathwaysmentioning
confidence: 99%