Insular changes induced by electroconvulsive therapy response to symptom improvements in schizophrenia

Jiang, Yuchao; Xia, Mengqing; Li, Xiangkui; Tang, Yingying; Li, Chunbo; Huang, Huan; Dong, Debo; Jiang, Sisi; Wang, Jijun; Xu, Jian; Chen, Luo; Yao, Dezhong

doi:10.1016/j.pnpbp.2018.09.009

Cited by 23 publications

(44 citation statements)

References 42 publications

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“…The present study implied that GMV values in the right vIa were correlated to the baseline PANSS negative symptoms subscale scores among the patients ( r = 0.384, p = .010), which might be used to predict negative symptomatic improvement, as shown by the SVR result. Previously, MECT together with antipsychotic drugs could increase GMV in the bilateral posterior insula, and the increased GMV in the posterior insula was associated with symptomatic improvements (Jiang et al, ). Moreover, another study reported that insular dysfunction was related to negative symptomatic severity among patients with remitted schizophrenia (Manoliu et al, ).…”

Section: Discussionmentioning

confidence: 98%

“…However, inconsistent results of insular GMV have been reported across schizophrenia studies (Shepherd et al, ). For example, no significant GMV difference was observed in the insula of treatment‐resistant schizophrenia and healthy controls (Jiang et al, ). Therefore, the relationship between insular GMV changes and disease progression or treatment effects in schizophrenia remains unclear.…”

Section: Introductionmentioning

confidence: 99%

“…Second, the effect of insular volumetric decreases on a region‐specific phenomenon remains unclear. Several studies indicated that anterior insula exhibited considerable GMV reductions in schizophrenia relative to posterior insula (Shepherd et al, ), whereas others observed no such decrease in the insula (Jiang et al, ). Such inconsistency may be attributed to lack of well‐defined parcellations.…”

Section: Introductionmentioning

confidence: 99%

“…Third, the ability of insular volumetric reduction to predict treatment response remains unknown. Modified electroconvulsive therapy (MECT) might induce increased insular GMV, which is correlated to symptomatic improvement in schizophrenia (Jiang et al, ). Another report showed that insular dysfunction is associated with negative symptomatic severity among patients with remitted schizophrenia (Manoliu et al, ).…”

Section: Introductionmentioning

confidence: 99%

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Region‐specific insular volumetric decreases in drug‐naive, first‐episode schizophrenia and their unaffected siblings

Liu

et al. 2019

American J of Med Genetics Pt B

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Decreased insular volume may be one of the anatomical alterations caused by schizophrenia. The possibility of region-specific insular volumetric reduction as an endophenotype and/or a possible treatment predictor is a critical issue with great implications for the diagnosis and prognosis of the disease. The sample of the current study comprised 44 drug-naive and first-episode patients, 42 unaffected siblings, and 44 healthy controls. A computational anatomy toolbox (CAT12) was applied to analyze the structural images with a fine-grained, cross-validated brainnetome atlas. Correlation analysis and support vector regression (SVR) were used to determine the relationship between insular deficits and symptomatic severity among patients. The gray matter volume (GMV) values in the left hypergranular insula (G) exhibited the following pattern: patients < siblings < controls. GMV values in the right ventral agranular insula (vIa) and baseline Positive and Negative Syndrome Scale negative symptoms subscale scores among patients showed a positive correlation (r = 0.384, p = .010). Further SVR analysis exhibited a significantly positive correlation between GMV values in the right vIa and negative symptomatic improvement among patients (r = 0.537, p < .001). Results suggested the presence of region-specific insular volumetric decreases in first-episode schizophrenia. Thus, volumetric decrease in left G might be a potential endophenotype for schizophrenia, and GMV values in right vIa might be used to predict negative symptomatic improvement in schizophrenia. K E Y W O R D S endophenotype, gray matter volume, insula, schizophrenia, treatment response

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Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Region‐specific insular volumetric decreases in drug‐naive, first‐episode schizophrenia and their unaffected siblings

Liu

et al. 2019

American J of Med Genetics Pt B

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“…The anterior insula and TPJ have been identified as key regions involved in the salience network, which is implicated in monitoring, detecting, and regulating salient stimuli from the internal and external environment [ 17 ]. This integration of the salience network may play a role for fundamental cognitive and behavioral function, and its alteration was found to associate with alteration of psychiatric symptoms in psychosis [ 18 , 19 ]. Consistent with previous researches, abnormal emotional processing, as well as cognitive impairment, such as attention, processing speed, and working memory, characterized euthymic PBD [ 4 , 20 ].…”

Section: Discussionmentioning

confidence: 99%

Altered Functional Integration in the Salience and Default Mode Networks in Euthymic Pediatric Bipolar Disorder

et al. 2020

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Accumulating studies demonstrate emotional and cognitive dysregulation in the euthymic period of pediatric bipolar disorder (PBD). However, the relative contribution of functional integration in human brain to disturbed emotion and cognitive function in the euthymic PBD patients remains unclear. In this study, 16 euthymic PBD patients and 16 healthy controls underwent resting-state functional magnetic resonance imaging. A data-driven functional connectivity analysis was used to investigate functional connectivity changes of the euthymic PBD. Compared with healthy controls, the euthymic PBD exhibited greater global functional connectivity density in the left anterior insula and lower global functional connectivity density in the right temporoparietal junction, the left angular gyrus, and the bilateral occipital lobule. A distant functional connectivity analysis demonstrated altered integration within the salience and default mode networks in euthymic PBD. Correlation analysis found that altered functional connectivity of the salience network was related to the reduced performance in the backward digit span test, and altered functional connectivity of the default mode network was related to the Young Mania Rating Scale in euthymic PBD patients. Our findings indicated that disturbed functional integration in salience and default mode networks might shed light on the physiopathology associated with emotional and cognitive dysregulation in PBD.

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Structural and functional brain alterations in subthreshold depression: A multimodal coordinate‐based meta‐analysis

Li,

Kuang,

Liu

et al. 2024

Human Brain Mapping

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Imaging studies of subthreshold depression (StD) have reported structural and functional abnormalities in a variety of spatially diverse brain regions. However, there is no consensus among different studies. In the present study, we applied a multimodal meta‐analytic approach, the Activation Likelihood Estimation (ALE), to test the hypothesis that StD exhibits spatially convergent structural and functional brain abnormalities compared to healthy controls. A total of 31 articles with 25 experiments were included, collectively representing 1001 subjects with StD. We found consistent differences between StD and healthy controls mainly in the left insula across studies with various neuroimaging methods. Further exploratory analyses found structural atrophy and decreased functional activities in the right pallidum and thalamus in StD, and abnormal spontaneous activity converged to the middle frontal gyrus. Coordinate‐based meta‐analysis found spatially convergent structural and functional impairments in StD. These findings provide novel insights for understanding the neural underpinnings of subthreshold depression and enlighten the potential targets for its early screening and therapeutic interventions in the future.

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Insular changes induced by electroconvulsive therapy response to symptom improvements in schizophrenia

Cited by 23 publications

References 42 publications

Region‐specific insular volumetric decreases in drug‐naive, first‐episode schizophrenia and their unaffected siblings

Region‐specific insular volumetric decreases in drug‐naive, first‐episode schizophrenia and their unaffected siblings

Altered Functional Integration in the Salience and Default Mode Networks in Euthymic Pediatric Bipolar Disorder

Structural and functional brain alterations in subthreshold depression: A multimodal coordinate‐based meta‐analysis

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