Inspiratory muscle training for advanced heart failure with lamin-related muscular dystrophy

Abstract

Background Some cases of advanced heart failure with dilated cardiomyopathy (DCM) are complicated by neuromuscular diseases, such as muscular dystrophy. The prognosis in DCM with muscular dystrophy is worse than that of DCM alone [1]. Lamin mutations are associated with significant arrhythmia and cardiomyopathy burden, and mutation of the lamin A/C gene is associated with variable skeletal muscle involvement [2]. Therefore, the prognosis in a patient with DCM is worse if the patient also has a lamin gene mutation.

Inspiratory Muscle Training in Patients with Heart Failure

“…To date, 26 articles have examined the effects of IMT in patients with HF (Table 1) [20,30,31,35,. Twenty-one of these studies were randomized clinical trials [20,30,31,35,[49][50][51][52][53][54][55][56][57][59][60][61][62][63][66][67][68][69] (Table 1a,b), four studies were quasi-experimental studies [48,58,64,65], and one study was a clinical case [59] ( Table 1c). The sample size for most of these studies was small.…”

“…The sample size for most of these studies was small. Most of the studies were carried out in patients with HFrEF [20,30,31,35,[48][49][50][51][52][53][54][55][59][60][61][62][63][64][65][66][67][68][69]. In addition, patients of the study carried out by Cahalin et al [65] were waiting for a heart transplant.…”

“…Other experimental studies included 4 quasi-experimental studies [48,58,64,65] and one clinical case [59]. Two of the quasi-experimental studies compared IMT with control or healthy groups.…”

Management Pengoptimalan Kebutuhan Oksigen Pada Pasien Gagal Jantung Di Unit Perawatan Intensif: A Literatur Review

“…Latihan tersebut menunjukkan adanya penurunan dalam penyerapan oksigen yang ditunjukkan dengan adanya kompromi yang signifikan terhadap toleransi latihan dan juga pasien mengalami kelemahan otot pernafasan yang parah. Latihan tersebut dilakukan dengan cara mengevaluasi otot pernafasan dan mengukur tekanan inspirasi maksimal (MIP) dan tekanan ekspirasi maksimal (MEP) (Taya & Amiya, 2019). Kelemahan otot pernafasan secara umum dipengaruhi oleh adanya penurunan volume tidal (TV) selama olahraga.…”

“…Pelatihan otot inspirasi (IMT) dapat digunakan sebagai intervensi bagi pasien ICU agar pasien dapat meningkatkan kekuatan otot inspirasi dan mempercepat proses penyapihan ventilasi mekanik (Bissett, Science, & Leditschke, 2018). Hal tersebut sesuai dengan kasus bahwa pasien setelah menjalani latihan tidak ditemukan adanya nilai peptida natriuretik obat (BNP) dan gangguan pernafasan pada pasien berkurang (Taya & Amiya, 2019). Hal ini berarti pasien mampu meningkatkan kekuatan otot inspirasi dan juga secara tidak langsung pasien berkontribusi untuk mengurangi jumlah dan derajat komplikasi pernafasan seperti pneumonia atau atelektasis.…”