Insomnia and suicidal ideation in nonaffective psychosis

Miller, Brian J.; Parker, Carmen Black; Rapaport, Mark Hyman; Buckley, Peter F.; McCall, W. Vaughn

doi:10.1093/sleep/zsy215

Cited by 42 publications

(15 citation statements)

References 61 publications

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“…Insomnia has been widely related to the acute emergence and persistence of suicidal thoughts. 69,[74][75][76] In keeping with this view, this symptom is a modifiable risk factor. Therefore, the early identification and treatment of even mild sleep disruptions might provide a meaningful benefit for patients with FEP presenting with fluctuating SI.…”

Section: F I G U R E 1 Predicted Trajectories Of Suicidal Ideationmentioning

confidence: 73%

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Trajectories of suicidal ideation after first‐episode psychosis: a growth mixture modeling approach

Salagre

Grande

Jiménez

et al. 2021

Acta Psychiatr Scand

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Objective: The period immediately after the onset of first-episode psychosis (FEP) may present with high risk for suicidal ideation (SI) and attempts, although this risk may differ among patients. Thus, we aimed to identify trajectories of SI in a 2-years follow-up FEP cohort and to assess baseline predictors and clinical/functional evolution for each trajectory of SI. Methods: We included 334 FEP participants with data on SI. Growth mixture modeling was used to identify trajectories of SI. Putative sociodemographic, clinical, and cognitive predictors of the distinct trajectories were examined using multinomial logistic regression.

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Section: F I G U R E 1 Predicted Trajectories Of Suicidal Ideationmentioning

confidence: 73%

“…In line with previous studies, our results also reveal that higher baseline scores in MADRS‐reduced sleep is associated with Worsening SI trajectory. Insomnia has been widely related to the acute emergence and persistence of suicidal thoughts 69,74‐76 . In keeping with this view, this symptom is a modifiable risk factor.…”

Section: Discussionmentioning

confidence: 91%

Trajectories of suicidal ideation after first‐episode psychosis: a growth mixture modeling approach

Salagre

Grande

Jiménez

et al. 2021

Acta Psychiatr Scand

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“…This is in agreement with a recent study by Miller et al, that recruited 108 patients with nonaffective psychosis, including schizophrenic individuals. The authors explored the association between insomnia, suicidal ideation, and the suicide-attempt histories of patients [ 7 ]. The results were quite interesting, as the patients with severe insomnia were more likely to have lifetime histories of suicide attempts than patients without insomnia, which suggests, once again, that an assessment of insomnia may be a marker of suicide risk and the severity of the symptoms.…”

Section: Introductionmentioning

confidence: 99%

Hormone Targets for the Treatment of Sleep Disorders in Postmenopausal Women with Schizophrenia: A Narrative Review

et al. 2022

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While the early identification of insomnia in patients with schizophrenia is of clinical relevance, the use of specific compounds to treat insomnia has been studied less in postmenopausal women with schizophrenia. We aimed to explore the effects of melatonin, sex hormones, and raloxifene for the treatment of insomnia in these populations. Although melatonin treatment improved the quality and efficiency of the sleep of patients with schizophrenia, few studies have explored its use in postmenopausal women with schizophrenia. The estrogen and progesterone pathways are dysregulated in major psychiatric disorders, such as in schizophrenia. While, in the context of menopause, a high testosterone-to-estradiol ratio is associated with higher frequencies of depressive symptoms, the effects of estradiol and other sex hormones on sleep disorders in postmenopausal women with schizophrenia has not been sufficiently investigated. Raloxifene, a selective estrogen receptor modulator, has shown positive effects on sleep disorders in postmenopausal women. Future studies should investigate the effectiveness of hormonal compounds on insomnia in postmenopausal women with schizophrenia.

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“…A oneyear follow-up study [8] of adolescents at high risk for psychiatric disorders found that circadian rhythm disorders predicted the severity of psychotic symptoms and psychosocial damage. Furthermore, in patients with schizophrenia, insomnia may lead to a signi cant reduction in quality of life [9] and a more than 10-fold increase in the risk of suicide [10]. There is no doubt that insomnia is very harmful to this group of population and is worthy of attention.…”

Section: Introductionmentioning

confidence: 99%

Insomnia Symptoms in Chinese Patients with Chronic Schizophrenia: Prevalence, Clinical Correlates and Relationship with Inflammation

Xia

Zhong

Liu

et al. 2020

Preprint

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Background: Sleep disturbances are common in patients with schizophrenia, with serious consequences. The purpose of this study was to investigate the prevalence and clinical correlates of insomnia symptoms, and to explore the relationship between insomnia and inflammatory markers in Chinese patients with chronic schizophrenia. Methods: A total of 328 inpatients with chronic schizophrenia were recruited. Insomnia Severity Index (ISI), Calgary Depression Scale for Schizophrenia (CDSS), and Positive and Negative Syndrome Scale (PANSS) were used to assess the severity of insomnia, depression, and psychotic symptoms. The plasma levels of several inflammatory markers (CRP, IL-6, and TNF-α) were measured.Results: The prevalence of insomnia symptoms in patients with schizophrenia was 38.4%. Depressive symptoms were significantly associated with insomnia symptoms (OR = 1.23, 95%CI: 1.13-1.33, P < 0.001). Higher CDSS score (beta = 0.55, t = 8.21, P < 0.001) and older age (beta = 0.06, t = 3.59, P < 0.001) were significantly associated with higher ISI score, while taking a single SGA (beta = -0.85, t = -1.99, P < 0.05) was independently associated with lower ISI score. There was no significant association between any inflammatory markers and insomnia or ISI score.Conclusions: Our results demonstrate that the prevalence of insomnia symptoms is high in Chinese inpatients with chronic schizophrenia. Some demographic and clinical variables, such as depressive symptoms and older age, are risk factors, while others are beneficial factor, such as taking atypical antipsychotic drug for insomnia in schizophrenia patients. No association has been found between insomnia symptoms and inflammation.

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Insomnia and suicidal ideation in nonaffective psychosis

Cited by 42 publications

References 61 publications

Trajectories of suicidal ideation after first‐episode psychosis: a growth mixture modeling approach

Trajectories of suicidal ideation after first‐episode psychosis: a growth mixture modeling approach

Hormone Targets for the Treatment of Sleep Disorders in Postmenopausal Women with Schizophrenia: A Narrative Review

Insomnia Symptoms in Chinese Patients with Chronic Schizophrenia: Prevalence, Clinical Correlates and Relationship with Inflammation

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