Insights into the naturally acquired immune response to<i>Plasmodium vivax</i>malaria

Longley, Rhea J.; Sattabongkot, Jetsumon; Müeller, Ivo

doi:10.1017/s0031182015000670

Cited by 53 publications

(56 citation statements)

References 219 publications

(357 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Malaria‐specific antibodies produced by antibody‐secreting B cells play a key role in limiting blood‐stage parasite multiplication and reducing the proportion of infections that progress to full‐blown disease . In Plasmodium vivax endemic settings, clinical immunity develops gradually after repeated exposure . Malaria attacks are experienced by both children and adults in communities across the Amazon, but an increased proportion of infections remains asymptomatic in subjects with more than 5‐8 years of continuous exposure to P vivax infection .…”

Section: Introductionmentioning

confidence: 99%

Apical membrane protein 1‐specific antibody profile and temporal changes in peripheral blood B‐cell populations in Plasmodium vivax malaria

Soares

Cunha

Ferraz-Nogueira

et al. 2019

Parasite Immunology

View full text Add to dashboard Cite

Plasmodium falciparum‐specific antibodies tend to be short‐lived, but their cognate memory B cells (MBCs) circulate in the peripheral blood of exposed subjects for several months or years after the last infection. However, the time course of antigen‐specific antibodies and B‐cell responses to the relatively neglected parasite Plasmodium vivax remains largely unexplored. Here, we showed that uncomplicated vivax malaria elicits short‐lived antibodies but long‐lived MBC responses to a major blood‐stage P vivax antigen, apical membrane protein 1 (PvAMA‐1), in subjects exposed to declining malaria transmission in the Amazon Basin of Brazil. We found that atypical (CD19+CD10−CD21−CD27−) MBCs, which appear to share a common precursor with classical MBCs but are unable to differentiate into antibody‐secreting cells, significantly outnumbered classical MBCs by 5:1 in the peripheral blood of adult subjects currently or recently infected with P vivax and by 3:1 in healthy residents in the same endemic communities. We concluded that malaria can drive classical MBCs to differentiate into functionally impaired MBCs not only in subjects repeatedly exposed to P falciparum, but also in subjects living in areas with low levels of P vivax transmission in the Amazon, leading to an impaired B‐cell memory that may affect both naturally acquired and vaccine‐induced immunity.

show abstract

Section: Introductionmentioning

confidence: 99%

Apical membrane protein 1‐specific antibody profile and temporal changes in peripheral blood B‐cell populations in Plasmodium vivax malaria

Soares

Cunha

Ferraz-Nogueira

et al. 2019

Parasite Immunology

View full text Add to dashboard Cite

show abstract

“…An effective and balanced immune response by the host is required for the control of P. vivax and its associated symptoms. Adaptive αβ T cells that include CD4 + and CD8 + T cells have been demonstrated to contribute to host immunity against P. vivax replication . In addition, a fraction of unconventional T cells, known as γδ T cells, is also important in providing protection against Plasmodium infections .…”

Section: Introductionmentioning

confidence: 99%

Exposure to Plasmodium vivax is associated with the increased expression of exhaustion markers on γδ T lymphocytes

Gogoi

Biswas

Borkakoty

et al. 2018

Parasite Immunology

View full text Add to dashboard Cite

Summary Gamma delta (γδ) T cells exhibit potent anti‐Plasmodium activity but are also implicated in the immunopathology of malaria. It is currently poorly understood how γδ T cells are affected in human suffering from Plasmodium vivax infection or in symptomless individuals living in an endemic region. We examined both the percentages and expression of markers associated with immune exhaustion in γδ T cells in individuals living in a P. vivax endemic region by flow cytometry. The percentage of γδ T cells in the blood was significantly higher both in acute P. vivax‐positive patients and in individuals from an endemic region in comparison with control uninfected adults. The frequency of the expression of the exhaustion markers‐Tim‐3, Lag‐3, CTLA‐4 and PD‐1 was higher in γδ and total T cells from P. vivax‐infected patients than in those populations from control uninfected adults. Individuals from a P. vivax endemic region showed elevated percentages of Tim‐3‐, Lag‐3‐ and CTLA‐4‐positive γδ T cells and an increased percentage of Tim‐3‐positive total T cells. The phenotypic exhaustion of these cells might be a protective mechanism preventing the immunopathology associated with activated T cells and may provide a rationale for targeted manipulation of this process in diseases such as malaria.

show abstract

“…Hence, a renewed and sustained effort will be required to eliminate P. vivax . A greater understanding of the antibody dynamics to P. vivax in this low-transmission region will be essential for developing and implementing key elimination tools, such as vaccines and improved surveillance methods [7]. …”

Section: Introductionmentioning

confidence: 99%

Asymptomatic Plasmodium vivax infections induce robust IgG responses to multiple blood-stage proteins in a low-transmission region of western Thailand

Longley

França

White

et al. 2017

Malar J

Self Cite

View full text Add to dashboard Cite

BackgroundThailand is aiming to eliminate malaria by the year 2024. Plasmodium vivax has now become the dominant species causing malaria within the country, and a high proportion of infections are asymptomatic. A better understanding of antibody dynamics to P. vivax antigens in a low-transmission setting, where acquired immune responses are poorly characterized, will be pivotal for developing new strategies for elimination, such as improved surveillance methods and vaccines. The objective of this study was to characterize total IgG antibody levels to 11 key P. vivax proteins in a village of western Thailand.MethodsPlasma samples from 546 volunteers enrolled in a cross-sectional survey conducted in 2012 in Kanchanaburi Province were utilized. Total IgG levels to 11 different proteins known or predicted to be involved in reticulocyte binding or invasion (ARP, GAMA, P41, P12, PVX_081550, and five members of the PvRBP family), as well as the leading pre-erythrocytic vaccine candidate (CSP) were measured using a multiplexed bead-based assay. Associations between IgG levels and infection status, age, and spatial location were explored.ResultsIndividuals from a low-transmission region of western Thailand reacted to all 11 P. vivax recombinant proteins. Significantly greater IgG levels were observed in the presence of a current P. vivax infection, despite all infected individuals being asymptomatic. IgG levels were also higher in adults (18 years and older) than in children. For most of the proteins, higher IgG levels were observed in individuals living closer to the Myanmar border and further away from local health services.ConclusionsRobust IgG responses were observed to most proteins and IgG levels correlated with surrogates of exposure, suggesting these antigens may serve as potential biomarkers of exposure, immunity, or both.Electronic supplementary materialThe online version of this article (doi:10.1186/s12936-017-1826-8) contains supplementary material, which is available to authorized users.

show abstract

Insights into the naturally acquired immune response toPlasmodium vivaxmalaria

Cited by 53 publications

References 219 publications

Apical membrane protein 1‐specific antibody profile and temporal changes in peripheral blood B‐cell populations in Plasmodium vivax malaria

Apical membrane protein 1‐specific antibody profile and temporal changes in peripheral blood B‐cell populations in Plasmodium vivax malaria

Exposure to Plasmodium vivax is associated with the increased expression of exhaustion markers on γδ T lymphocytes

Asymptomatic Plasmodium vivax infections induce robust IgG responses to multiple blood-stage proteins in a low-transmission region of western Thailand

Contact Info

Product

Resources

About