Insights into the multifactorial causation of obesity by integrated genetic and epigenetic analysis

Abstract

Obesity is a highly heritable multifactorial disease that places an enormous burden on human health. Its increasing prevalence and the concomitant-reduced life expectancy has intensified the search for new analytical methods that can reduce the knowledge gap between genetic susceptibility and functional consequences of the disease pathology. Although the influence of genetics and epigenetics has been studied independently in the past, there is increasing evidence that genetic variants interact with environmental factors through epigenetic regulation. This suggests that a combined analysis of genetic and epigenetic variation may be more effective in characterizing the obesity phenotype. To date, limited genome-wide integrative analyses have been performed. In this review, we provide an overview of the latest findings, advantages, and challenges and discuss future perspectives.

Cardiometabolic markers among Argentinean normal weight and overweight children with and without central obesity

“…There are no sufficient data about the influence of genetics and epigenetics among healthy and unhealthy phenotypes. However, it is probable that both genetic and epigenetic variation might be associated with these different phenotypes ( 29 ). Moreover, limited genome-wide integrative analyses have been performed yet ( 29 ).…”

Asociación del peso al nacer con adiposidad en niños escolares de distintas regiones de Argentina

“…Más aún, el OR del trabajo realizado en 12 países es muy similar al de nuestro trabajo (OR 2.48) elaborado en diferentes regiones de nuestro país. La diversidad genética y epigenética probablemente podría asociarse al desarrollo de SP/OB durante la infancia en niños con PN alto 23 . Sin embargo, el análisis de todo el genoma aún no se realizó 23 .…”

“…La diversidad genética y epigenética probablemente podría asociarse al desarrollo de SP/OB durante la infancia en niños con PN alto 23 . Sin embargo, el análisis de todo el genoma aún no se realizó 23 . Esto sugiere que hay que seguir de cerca a los niños con alto PN y aconsejar cambios en el estilo de vida para prevenir futuras enfermedades cardiometabólicas.…”

Obesity: epidemiology, etiopathogenesis, comorbidity, diagnosis and treatment

“…Ожирение также влияет на развитие мужского бесплодия. У мужчин с ожирением выявлено уменьшение количества, концентрации, нарушение подвижности и морфологии сперматозоидов [18].…”

“…Бурая жировая ткань состоит из меньших по размеру адипоцитов, имеющих большее количество митохондрий. Выполняет структурную и терморегуляторную функции, образует тепло в организме за счет действия разобщающего белка-1 или термогенина [17][18][19][20]. Механизмы, определяющие индивидуальные различия в распределении жира в организме, сложны и до конца не изучены.…”