2016
DOI: 10.1007/s00203-016-1205-9
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Abstract: The anticandidal potential of Geraniol (Ger) against Candida albicans has already been established. The present study reveals deeper insights into the mechanisms of action of Ger. We observed that the repertoire of antifungal activity was not only limited to C. albicans and its clinical isolates but also against non-albicans species of Candida. The membrane tampering effect was visualized through transmission electron micrographs, depleted ergosterol levels and altered plasma membrane ATPase activity. Ger also… Show more

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Cited by 43 publications
(40 citation statements)
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“…Spot assay: spot assays were performed as previously described (5) (9) . Briefl y, 5μl of fi vefold serial dilutions of each yeast culture (each with cells suspended in normal saline to an OD 600 of 0.1) was spotted onto YEPD plates in the absence (control) and presence of Cit (0.8, 1, or 1.2mg/ml).…”
Section: Drug Susceptibility Assaysmentioning
confidence: 99%
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“…Spot assay: spot assays were performed as previously described (5) (9) . Briefl y, 5μl of fi vefold serial dilutions of each yeast culture (each with cells suspended in normal saline to an OD 600 of 0.1) was spotted onto YEPD plates in the absence (control) and presence of Cit (0.8, 1, or 1.2mg/ml).…”
Section: Drug Susceptibility Assaysmentioning
confidence: 99%
“…Sterols were extracted using the alcoholic KOH method and the percentage of ergosterol was calculated as previously described (5) (9) . Briefl y, a single C. albicans colony from an overnight YEPD agar plate culture was used to inoculate 50ml of YEPD in the absence and presence of Cit at its subinhibitory concentration.…”
Section: Ergosterol Quantifi Cationmentioning
confidence: 99%
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