2022
DOI: 10.3389/fragi.2022.854157
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Abstract: Protein homeostasis (proteostasis) is maintained by a tightly regulated and interconnected network of biological pathways, preventing the accumulation and aggregation of damaged or misfolded proteins. Thus, the proteostasis network is essential to ensure organism longevity and health, while proteostasis failure contributes to the development of aging and age-related diseases that involve protein aggregation. The model organism Caenorhabditis elegans has proved invaluable for the study of proteostasis in the co… Show more

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Cited by 3 publications
(3 citation statements)
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References 189 publications
(278 reference statements)
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“…As mentioned previously, a wide range of literature reports that proteasome activity declines with age in many model systems ( 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 ), and its inhibition leads to a dramatically decreased lifespan in C. elegans ( 66 ). In addition, many long-lived nematode mutants are characterized by increased proteostasis ( 67 ), which has been linked in some ( i.e. , dnj-21 and glp-1 ) to increased UPS activity ( 68 , 69 ).…”
Section: Resultsmentioning
confidence: 99%
“…As mentioned previously, a wide range of literature reports that proteasome activity declines with age in many model systems ( 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 ), and its inhibition leads to a dramatically decreased lifespan in C. elegans ( 66 ). In addition, many long-lived nematode mutants are characterized by increased proteostasis ( 67 ), which has been linked in some ( i.e. , dnj-21 and glp-1 ) to increased UPS activity ( 68 , 69 ).…”
Section: Resultsmentioning
confidence: 99%
“…Whether integration of the DDR and the UPR-ER also occurs in animals, and how different tissues respond in this context is less well understood. In the nematode worm Caenorhabditis elegans, DNA damage in the adult germline promotes stress resistance in the postmitotic soma via MAP kinase signaling, innate immune responses, and the ubiquitin proteasome system (Ermolaeva et al 2013), which, like the UPR-ER, maintains proteostasis (Papaevgeniou and Chondrogianni 2014;Zhang et al 2022). Moreover, C. elegans xbp-1 is required to express DNA repair genes (Shen et al 2005).…”
Section: Introductionmentioning
confidence: 99%
“…In the nematode worm Caenorhabditis elegans , DNA damage in the adult germline promotes stress resistance in the postmitotic soma via MAP kinase signaling, innate immune responses, and the ubiquitin proteasome system (Ermolaeva et al . 2013), which, like the UPR-ER, maintains proteostasis (Papaevgeniou and Chondrogianni 2014; Zhang et al . 2022).…”
Section: Introductionmentioning
confidence: 99%