2017
DOI: 10.1590/0037-8682-0114-2017
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Abstract: Introduction: Citronellal (Cit) possesses antifungal activity and has possible implications for reactive oxygen species (ROS) generation in Candida albicans. In this study, the effects of Cit on ROS generation and the mechanisms by which Cit exerts anti-Candida effects were examined. Methods: A 2′,7′-dichlorodihydrofluorescein diacetate assay was used to assess oxidative damage. Cell necrosis was determined by flow cytometry after FITC-Annexin V staining. Mitochondrial function was studied based on mitochondri… Show more

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Cited by 23 publications
(23 citation statements)
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References 18 publications
(23 reference statements)
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“…The activity of this EO would be related to the large amount of limonene, sabinene and citronellal. These compounds strongly inhibit C. albicans [22,23,24]. However, S. cerevisiae showed a reduced sensitivity versus other EOs provided of antifungal activity, such as L. cubeba and C. citratus.…”
Section: Discussionmentioning
confidence: 99%
“…The activity of this EO would be related to the large amount of limonene, sabinene and citronellal. These compounds strongly inhibit C. albicans [22,23,24]. However, S. cerevisiae showed a reduced sensitivity versus other EOs provided of antifungal activity, such as L. cubeba and C. citratus.…”
Section: Discussionmentioning
confidence: 99%
“…The transcription inhibition of one of the genes encoding aspartyl proteinases seems to have a direct effect on the reduction of the secretion of Saps. Many reports indicate that natural herbal products contribute to the inhibition of the expression of critical adhesion and hyphal growth-associated genes [29][30][31].…”
Section: Resultsmentioning
confidence: 99%
“…A non-fermentable carbon source is a carbon source for mitochondrial respiratory metabolism . Cells with damaged mitochondria cannot grow in a non-fermentable carbon source medium (Robinson et al, 1992;Saibabu et al, 2017). The growth status of C. albicans kcs1 / and vip1 / in non-fermentable carbon source glycerol medium was not different from that of the WT strain.…”
Section: Vip1 / Grown In Glucose Instead Of Glycerol Has Reduced Mitomentioning
confidence: 89%