Insights into the importance of dietary chrysanthemum flower (Chrysanthemum morifolium cv. Hangju)-wolfberry (Lycium barbarum fruit) combination in antioxidant and anti-inflammatory properties

Zhang, Nan; He, Zhengjun; He, Siyu; Jing, Pu

doi:10.1016/j.foodres.2018.09.015

Cited by 54 publications

(28 citation statements)

References 37 publications

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“…It is reported in Chinese Pharmacopoeia that drinking C. morifolium tea (infusion) could help alleviating headache and preventing the occurrence of cold and fever [5,6,7,8]. Additionally, drinking C. morifolium tea has the potential to improve the eye function [5,6,7,9].…”

Section: Introductionmentioning

confidence: 99%

“…Recent pharmacological studies demonstrate that C. morifolium possesses a wide array of health potentials, such as anti-bacterial, anti-viral and anti-inflammatory capacities [4,6,8,9,10,11,12]. During its long evolution, ‘Hangju’, ‘Boju’, ‘Chuju’, and ‘Gongju’ are the four main varieties of C. morifolium cited in the Chinese Pharmacopeia [7].…”

Section: Introductionmentioning

confidence: 99%

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Comparison of Phenolic Compounds and the Antioxidant Activities of Fifteen Chrysanthemum morifolium Ramat cv. ‘Hangbaiju’ in China

et al. 2019

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This study investigated the phenolic compounds of 15 Chrysanthemum morifolium Ramat cv. ‘Hangbaiju’, including 6 ‘Duoju’ and 9 ‘Taiju’, using high performance liquid chromatography (HPLC). The antioxidant activities of these ‘Hangbaiju’ were estimated by DPPH, ABTS and FRAP assays. Results show that a total of 14 phenolic compounds were detected in these flowers, including 3 mono-caffeoylquinic acids, 3 di-caffeoylquinic acids, 1 phenolic acid and 7 flavonoids. ‘Duoju’ and ‘Taiju’ possess different concentrations of phenolic compounds, and ‘Taiju’ exhibits higher caffeoylquinic acids and stronger antioxidant activities than ‘Duoju’. Caffeoylquinic acids show a strong correlation with the antioxidant activities of the samples. Principal component analysis (PCA) reveals an obvious separation between ‘Duoju’ and ‘Taiju’, using phenolic compounds as variables. Apigenin-7-O-glucoside, 3,5-di-O-caffeoylquinic acid, luteolin and acacetin were found to be the key phenolic compounds to differentiate ‘Duoju’ from ‘Taiju’.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Comparison of Phenolic Compounds and the Antioxidant Activities of Fifteen Chrysanthemum morifolium Ramat cv. ‘Hangbaiju’ in China

et al. 2019

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“…The main active ingredients of TFDM are tilianin (13.0 to 17.0%), acacetin-7-O-β-D-glucuronide (10.0 to 13.5%), luteolin-7-O-β-D-glucuronide (8.0 to 9.0%), diosmetin − 7-O-β-D-glucuronide (7.0 to 8.6%) and apigenin-7-O-β-D-glucuronide (2.0 to 3.0%). It has been reported that these flavonoids have antiinflammatory and antioxidant stress effects [7][8][9][10][11][12]. In general, flavonoids are the most powerful and widely used bioactive compounds in plants and have cardioprotective and neuroprotective effects and have cardioprotective and neuroprotective effects [13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Total flavones of Dracocephalum moldavica L. protect astrocytes against H2O2-induced apoptosis through a mitochondria-dependent pathway

Zheng

Zeng

et al. 2020

BMC Complement Med Ther

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Background: The active components of Dracocephalum moldavica L. (TFDM) can inhibit myocardial ischemia by inhibiting oxidative stress. However, the effects of TFDM on astrocytes have not been investigated in vitro. The current study aimed to explore whether TFDM protects astrocytes against H 2 O 2-induced apoptosis through a mitochondria-dependent pathway. Methods: The human glioma cell line U87 was used to investigate the ability of TFDM to protect astrocytes against H 2 O 2-induced apoptosis. The cell counting kit-8 assay and flow cytometry were used to detect cell viability, apoptosis, MMP, Ca 2+ influx and reactive oxygen species (ROS). Lactate dehydrogenase (LDH) and malonic dialdehyde (MDA) levels were measured by ELISA. In addition, protein and mRNA expression changes were detected by Western blotting and qRT-PCR. Results: TFDM (0.78~200 μg/ml) had limited cytotoxic effects on the viability of U87 cells. Compared with the model group (treated with H2O2 only), cells treated with medium-and high-dose TFDM exhibited reduced MDA concentrations (P < 0.05) and ROS production (P < 0.05) and decreased MMP (P < 0.05) and reduced apoptosis (P < 0.05). The percentage of annexin V-FITC-stained cells was markedly suppressed by TFDM, confirming its antiapoptotic properties. WB results showed that protein expression of Bcl-2-associated X protein (BAX), Caspase-3, Caspase-9, Caspase-12, and B-cell leukemia/lymphoma 2 (Bcl2) was reduced in the TFDM group compared with that in the model group (P < 0.05) and that expression of these proteins was normalized by TFDM treatment in a dosedependent manner. According to RT-qPCR results, TFDM pretreatment resulted in reduced mRNA expression of BAX, Caspase-9, Caspase-12, p38MAPK, and CaMKII and increased mRNA expression of mTOR compared with the model group. Conclusions: The current study revealed the protective effects of TFDM on U87 cells under oxidative stress conditions through the inhibition of a mitochondria-dependent pathway that is associated with the CaMKII/ P38MAPK/ERK1/2 and PI3K/AKT/mTOR pathways.

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“…It is reported in Chinese Pharmacopoeia that drinking C. morifolium tea (infusion) could help alleviating headache and preventing the occurrence of cold and fever [5][6][7][8]. Additionally, drinking C. morifolium tea has the potential to improve the eye function [5][6][7]9]. Recent harmacological studies demonstrated that C. morifolium possess a wide array of health potentials, such as anti-bacterial, anti-viral and anti-inflammatory capacities [4,6,[8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

“…Additionally, drinking C. morifolium tea has the potential to improve the eye function [5][6][7]9]. Recent harmacological studies demonstrated that C. morifolium possess a wide array of health potentials, such as anti-bacterial, anti-viral and anti-inflammatory capacities [4,6,[8][9][10][11][12]. During its long evolution, 'Hangju', 'Boju', 'Chuju', and 'Gongju' are the four main varieties of C. morifolium cited in the Chinese Pharmacopeia [7].…”

Section: Introductionmentioning

confidence: 99%

Comparison of Phenolic Compounds and Antioxidant Activities of Fifteen Chrysanthemum morifolium Ramat cv. ‘Hangbaiju’ in China

Gong¹,

Chu²,

Gong³

et al. 2019

Preprint

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This study investigated the phenolic compounds of 15 Chrysanthemum morifolium Ramat cv. ‘Hangbaiju’, including 6 ‘Duoju’ and 9 ‘Taiju’ using high performance liquid chromatography. The antioxidant activities of these ‘Hangbaiju’ were estimated by DPPH, ABTS and FPAR assays. Results showed that a total of 14 phenolic compounds were detected in these flowers, including 3 mono-caffeoylquinic acids, 3 di-caffeoylquinic acids, 1 phenolic acid and 7 flavonoids. ‘Duoju’ and ‘Taiju’ possessed different concentration of phenolic compounds, and ‘Taiju’ exhibited higher caffeoylquinic acids and stronger antioxidant activities than ‘Duoju’. Caffeoylquinic acids showed a strong correlation with the antioxidant activities of the samples. Principal component analysis revealed an obvious separation between ‘Duoju’ and ‘Taiju’ using phenolic compounds as variables. Apigenin-7-O-glucoside, 3,5-di-O-caffeoylquinic acid, luteolin and acacetin were found to be the key phenolic compounds to differentiate ‘Duoju’ from ‘Taiju’.

show abstract

Insights into the importance of dietary chrysanthemum flower (Chrysanthemum morifolium cv. Hangju)-wolfberry (Lycium barbarum fruit) combination in antioxidant and anti-inflammatory properties

Cited by 54 publications

References 37 publications

Comparison of Phenolic Compounds and the Antioxidant Activities of Fifteen Chrysanthemum morifolium Ramat cv. ‘Hangbaiju’ in China

Comparison of Phenolic Compounds and the Antioxidant Activities of Fifteen Chrysanthemum morifolium Ramat cv. ‘Hangbaiju’ in China

Total flavones of Dracocephalum moldavica L. protect astrocytes against H2O2-induced apoptosis through a mitochondria-dependent pathway

Comparison of Phenolic Compounds and Antioxidant Activities of Fifteen Chrysanthemum morifolium Ramat cv. ‘Hangbaiju’ in China

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Insights into the importance of dietary chrysanthemum flower (Chrysanthemum morifolium cv. Hangju)-wolfberry (Lycium barbarum fruit) combination in antioxidant and anti-inflammatory properties

Cited by 54 publications

References 37 publications

Comparison of Phenolic Compounds and the Antioxidant Activities of Fifteen Chrysanthemum morifolium Ramat cv. ‘Hangbaiju’ in China

Comparison of Phenolic Compounds and the Antioxidant Activities of Fifteen Chrysanthemum morifolium Ramat cv. ‘Hangbaiju’ in China

Total flavones of Dracocephalum moldavica L. protect astrocytes against H2O2-induced apoptosis through a mitochondria-dependent pathway

Comparison of Phenolic Compounds and Antioxidant Activities of Fifteen Chrysanthemum morifolium Ramat cv. &lsquo;Hangbaiju&rsquo; in China

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Comparison of Phenolic Compounds and Antioxidant Activities of Fifteen Chrysanthemum morifolium Ramat cv. ‘Hangbaiju’ in China