Biochemical Pharmacology volume 78, issue 7, P777-787 2009 DOI: 10.1016/j.bcp.2009.06.098 View full text
Prakash Rucktooa, August B. Smit, Titia K. Sixma

Abstract: AbstractNicotinic acetylcholine receptors (nAChRs) display a broad variety of subtypes, which in turn present a complex subcellular and regional expression pattern in the brain, as well as a specific pharmacological profile. The association of these nAChRs with different types of brain disease has turned them into interesting drug targets for the treatment of Alzheimer's disease or schizophrenia, or for anti-smoking compounds among others. In the same way, muscle-type nAChRs present at neuromuscular junctions…

expand abstract