Insertion/Deletion Polymorphism and Serum Activity of the Angiotensin-Converting Enzyme in Turkish Patients with Obstructive Sleep Apnea Syndrome

Abstract

This study determined the allelic frequency and genotypic distribution of an angiotensin-converting enzyme (ACE) polymorphism and serum ACE activity in Turkish patients with obstructive sleep apnea syndrome (OSAS). A colorimetric assay measured serum ACE activity in 73 of 97 subjects. Frequencies for II, ID, and DD genotypes were 19.6, 53.6, and 26.8% in the OSAS group and 15, 38, and 47% in the control group, respectively (P = 0.02). The I allele frequency was higher in the OSAS group than in the healthy control group (P = 0.02). Carrying the I allele (II or ID genotypes) increased OSAS risk 2.41 times in the Turkish population. Mean ACE activity was significantly lower in patients with the II genotype than in the DD genotype (P = 0.011), and ACE activity was significantly lower in patients with severe OSAS than in those with mild OSAS (P = 0.006). Our results suggest that II and ID genotypes of the ACE gene increase the risk of developing OSAS in the Turkish population.

Meta-analysis demonstrates lack of association between the ACE gene I/D polymorphism and obstructive sleep apnea-hypopnea syndrome occurrence and severity

“…Ogus et al (2010) found that ACE activity was significantly lower in severe than in mild OSAS. However, genotype differences do not exist between mild/moderate OSAHS and severe OSAHS in Ogus et al (2010) and 4 other studies in our meta-analysis.…”

“…Based on our search strategy, the primary screening produced 21 potentially relevant articles, of which 15 met the inclusion criteria as an attempt to evaluate the association between the ACE I/D polymorphism and occurrence of OSAHS (Xiao et al, 1999;Zhang et al, 2000;Barcelo et al, 2001;Ping et al, 2001;Li et al, 2004a,b;Lin et al, 2004;Zhang et al, 2004;Gu et al, 2006;Li et al, 2006;Bostrom et al, 2007;Benjamin et al, 2008;Koyama et al, 2009;Ogus et al, 2010;Yakut et al, 2010). A total of 1361 OSAHS patients and 1373 controls were analyzed.…”

“…A total of 1361 OSAHS patients and 1373 controls were analyzed. Of these 15 articles, 9 (Xiao et al, 1999;Zhang et al, 2000;Barcelo et al, 2001;Lin et al, 2004;Bostrom et al, 2007;Benjamin et al, 2008;Koyama et al, 2009;Ogus et al, 2010;Yakut et al, 2010) were published in English and 6 in Chinese (Ping et al, 2001;Li et al, 2004a,b;Zhang et al, 2004;Gu et al, 2006;Li et al, 2006). The detailed selection process is presented in Figure 1.…”

“…Of these 15 articles, 13 studies followed a hospital-based study design and 2 followed a population-based study design. Five studies were included in the analysis of the ACE I/D polymorphism and OSAHS severity (Zhang et al, 2000;Lin et al, 2004;Bostrom et al, 2007;Koyama et al, 2009;Ogus et al, 2010). There were 13 case-control studies including a study of the association between the ACE I/D polymorphism and OSAHS risk, 8 of Chinese, 3 of Caucasians, and 2 of Arabs.…”

Lack of Association of Insulin Receptor Substrate Gene Polymorphisms with Obstructive Sleep Apnea Syndrome

“…There are studies [24,25] related angiotensin-converting enzyme (ACE) and IRS-1 gene polymorphisms [26], in related to sleep apne risk in Turkish patients with OSAS. Besides, IRS gene polymorphisms were investigated in glucose metabolism disorders [27,28].…”