Cell Reports volume 3, issue 6, P1866-1873 2013 DOI: 10.1016/j.celrep.2013.05.035 View full text
|
|
Share
Donatella Giovannini, Jawida Touhami, Pierre Charnet, Marc Sitbon, Jean-Luc Battini

Abstract: Inorganic phosphate uptake is a universal function accomplished by transporters that are present across the living world. In contrast, no phosphate exporter has ever been identified in metazoans. Here, we show that depletion of XPR1, a multipass membrane molecule initially identified as the cell-surface receptor for xenotropic and polytropic murine leukemia retroviruses (X- and P-MLV), induced a decrease in phosphate export and that reintroduction of various XPR1 proteins, from fruit fly to human, rescued this…

expand abstract