2020
DOI: 10.1007/s00423-020-01957-1
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Abstract: Purpose In most cases, traditional techniques to perform an anastomosis following gastrointestinal resections lead to successful healing. However, despite focused research in the field, in certain high-risk situations leakage rates remain almost unchanged. Here, additional techniques may help the surgeon to protect the anastomosis and prevent leakage. We give an overview of some of the latest developments on experimental and clinical techniques for induction of anastomotic healing. Methods We performed a revie… Show more

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Cited by 16 publications
(9 citation statements)
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References 94 publications
(101 reference statements)
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“…Local administration of ozone can improve healing disturbances that occur in the colon mucosa due to radiotherapy. 29 The main difference between our study and previous studies is the application method. 16 The rectal administration method can be translated to human studies and is the main difference between intraperitoneal administration.…”
Section: Discussionmentioning
confidence: 78%
“…Local administration of ozone can improve healing disturbances that occur in the colon mucosa due to radiotherapy. 29 The main difference between our study and previous studies is the application method. 16 The rectal administration method can be translated to human studies and is the main difference between intraperitoneal administration.…”
Section: Discussionmentioning
confidence: 78%
“…Preoperative, tumor-associated, intraoperative, and other risk factors for AL have been identified so far [ 4 , 5 ]. Research in the field thus focuses on identifying biomarkers for AL as well as finding optimal surgical techniques, biomaterials, and targeted drugs to reduce the risk of AL after gastrointestinal surgery; however, no treatment option except for diverting enterostomy exists so far to reliably prevent AL [ 6 ]. AL rates after lower gastrointestinal surgery are reported in the literature to occur in 1–19% of operations; however, reported leakage rates vary largely across studies [ 4 , 7 9 ].…”
Section: Introductionmentioning
confidence: 99%
“…Based on our group’s experience using ASCs in experimental and clinical settings (conducting or participating in more than 13 clinical trials) and in digestive surgery, our aim was to review the published literature related to SC use for digestive anastomoses and registered clinical trials. To the best of our knowledge, Caziuc et al [ 33 ] published the only review focused on this field, including studies published prior to September 2014, and other reviews have dedicated brief sections to SCs, such as those by Foppa et al [ 34 ] and Reischl et al [ 35 ].…”
Section: Introductionmentioning
confidence: 99%